Abstract: The present invention relates to methods for performing antisense oligonucleotide-mediated exon skipping in the retina of a subject in need thereof. In particular, the present invention relates to a method for performing antisense oligonucleotide-mediated exon skipping in a retina cell of a subject comprising the step of injecting into the vitreous of the subject an amount of the antisense oligonucleotide.

Abstract: The novel, knocked-down storage trunk comprising the present invention includes two rigid, molded plastic shells and pairs of side and end walls. In the assembled condition a first pair of lower, inner and outer, concentric clamp rings are used to secure the lower edge of the side and end walls to the lower shell. A second, upper pair of inner and outer concentric clamp rings are secured to the upper edges of the side and end walls. Mating inner and outer vertical corner members are secured to each other and are captured in the upper and lower pairs of concentric clamp rings. The upper shell is hingedly secured to the rear side wall and conventional locks extend between and serve to couple the upper shell and the front side wall. In the knocked-down condition the upper shell nests within the lower shell and the lower shell is seated within the lower concentric pair of clamp rings.