Abstract: A method of treating a person having a foot odor comprises administering an effective foot odor treatment amount of an antimicrobial preparation, such as Polymyxin B. Sulfate, Bacitracin Zinc, and an antimicrobial such as Miconazole Nitrate, terbinafine hydrochloride, undecylenic acid, tolnaftate, clotrimazole, or butenafine hydrochloride, to eliminate or reduce the symptoms of foot odor. The present invention is a topical skin preparation for treatment of foot odor. The preparation comprises Polymyxin B Sulfate and Bacitracin Zinc in combination with an antimicrobial agent. In a preferred form, the preparation further comprises, an antimicrobial such as Miconazole Nitrate. The concentrations of these constituents are 10,000 units of Polymyxin B Sulfate, 500 units of Bacitracin Zinc and 1.0 to 2.0% concentration of Miconazole Nitrate, in one preferred embodiment.