Abstract: The present invention relates to methods for performing antisense oligonucleotide-mediated exon skipping in the retina of a subject in need thereof. In particular, the present invention relates to a method for performing antisense oligonucleotide-mediated exon skipping in a retina cell of a subject comprising the step of injecting into the vitreous of the subject an amount of the antisense oligonucleotide.

Abstract: A device for printing on hollow bodies comprises a mandrel wheel and a segment wheel. The mandrel wheel has its own motor separate from a motor of the segment wheel. In association with the segment wheel, along a circumferential line thereof, a plurality of plate cylinders are positioned or at least are positionable radially against this segment wheel. An inking unit is associated with each plate cylinder. Each plate cylinder, and a roller arranged in the associated inking unit, are each driven in rotation independently by a motor. The motor of the mandrel wheel and the motor of the segment wheel and the motor of the relevant plate cylinder and the motor of the roller arranged in the associated inking unit are connected to one another for data exchange by a common data bus. The relevant motors each have their own drive controller and their own power part connected to the data bus. Control data for the relevant motors, transported via the data bus, form a virtual guide axis.

Abstract: A device for printing on hollow bodies comprises a mandrel wheel and a segment wheel. The mandrel wheel has its own motor separate from a motor of the segment wheel. In association with the segment wheel, along a circumferential line thereof, a plurality of plate cylinders are positioned or at least are positionable radially against this segment wheel. An inking unit is associated with each plate cylinder. Each plate cylinder, and a roller arranged in the associated inking unit, are each driven in rotation independently by a motor. The motor of the mandrel wheel and the motor of the segment wheel and the motor of the relevant plate cylinder and the motor of the roller arranged in the associated inking unit are connected to one another for data exchange by a common data bus. The relevant motors each have their own drive controller and their own power part connected to the data bus. Control data for the relevant motors, transported via the data bus, form a virtual guide axis.

Abstract: An improved method for retaining a separable bearing race to a inner bearing member and also preventing twisting of the separable race on the spindle. The circular corner edge where the cylindrical inner surface of the separable race would otherwise intersect with the annular, axial face of the race is machined off with a chamfer that is eccentric to the co axis of the race and spindle. Then, a deformable lip of the spindle is deformed in and over the face of the race, concurrently filling in the eccentric chamfer. When the race thereafter attempts to turn on the spindle, a wedging action is created by the eccentric chamfer to prevent twisting.

Abstract: The invention relates to a device for feeding, with elongate lining material, an installation for lining a tubular member such as a pipe having a diameter of the order of 650 to 1,000 mm, particularly in the nuclear industry. The pipe is placed with its axis horizontal on a support which enables it to be rotated about its axis. The lining installation comprises a vertical welding head which is mounted on the end of a horizontal arm, the position of which is adjustable to introduce the welding head into the pipe. The elongate lining material is supplied to the welding head by a feed device comprising a reel on which the lining material is wound, and which is arranged at the front of the welding head. The reel is mounted so as to rotate on an axle fixed relative to the end of the arm and whose axis forms a small angle with the axis of the arm. The device also comprises adjustable means for guiding the lining material from a low part of the reel to an upper part of the welding head.