Patents by Inventor Arnold S. Freedman

Arnold S. Freedman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polypeptides comprising a B7 extracellular domain
    Patent number: 6653444
    Abstract: Isolated nucleic acid molecules encoding a B cell activation antigen, B7, are provided. In one embodiment, the nucleic acid molecules are DNA sequences. The DNA sequences of the invention can be integrated into various expression vectors, which in turn can direct the synthesis of the corresponding proteins or peptides in a variety of hosts, particularly eukaryotic cells, such as mammalian and insect cell culture. Also provided are host cells transformed to produce proteins or peptides encoded by the DNA molecules of the present invention and purified proteins and peptides which comprise at least a portion of the B cell activation antigen. The proteins and peptides comprise at least a portion of the mature form of the B7 activation antigen and preferably comprise a soluble form of the B7 protein.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: November 25, 2003
    Assignee: Dana-Farber Cancer Institute, Inc.
    Inventors: Gordon J. Freeman, Arnold S. Freedman, Lee M. Nadler
  • DNA encoding B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells
    Publication number: 20030170821
    Abstract: Isolated nucleic acid molecules encoding a B cell activation antigen, B7, are provided. In one embodiment, the nucleic acid molecules are DNA sequences. The DNA sequences of the invention can be integrated into various expression vectors, which in turn can direct the synthesis of the corresponding proteins or peptides in a variety of hosts, particularly eukaryotic cells, such as mammalian and insect cell culture. Also provided are host cells transformed to produce proteins or peptides encoded by the DNA molecules of the present invention and purified proteins and peptides which comprise at least a portion of the B cell activation antigen. The proteins and peptides comprise at least a portion of the mature form of the B7 activation antigen and preferably comprise a soluble form of the B7 protein.
    Type: Application
    Filed: April 19, 2002
    Publication date: September 11, 2003
    Applicant: The Dana-Farber Cancer Institute
    Inventors: Gordon J. Freeman, Arnold S. Freedman, Lee M. Nadler
  • DNA encoding, B7, a new member of the IG superfamily with unique expression on activated and neoplastic B cells
    Patent number: 6071716
    Abstract: Isolated nucleic acid molecules encoding a B cell activation antigen, B7, are provided. In one embodiment, the nucleic acid molecules are DNA sequences. The DNA sequences of the invention can be integrated into various expression vectors, which in turn can direct the synthesis of the corresponding proteins or peptides in a variety of hosts, particularly eukaryotic cells, such as mammalian and insect cell culture. Also provided are host cells transformed to produce proteins or peptides encoded by the DNA molecules of the present invention and purified proteins and peptides which comprise at least a portion of the B cell activation antigen. The proteins and peptides comprise at least a portion of the mature form of the B7 activation antigen and preferably comprise a soluble form of the B7 protein.
    Type: Grant
    Filed: November 15, 1993
    Date of Patent: June 6, 2000
    Assignee: Dana-Farber Cancer Institute
    Inventors: Gordon J. Freeman, Arnold S. Freedman, Lee M. Nadler