Patents by Inventor Arnoldus H. J. Herremans

Arnoldus H. J. Herremans has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 1H-imidazole derivative having CB, agonistic, CBpartial agonistic or CBantagnistic activity
    Patent number: 8729101
    Abstract: The present invention relates to a group of novel 1H-imidazole derivatives, to methods for the preparation of these compounds, and to pharmaceutical compositions containing one or more of these compounds as an active component. These 1H-imidazole derivatives are potent cannabinoid-CB1 receptor agonists, partial agonists or antagonists, useful for the treatment of psychiatric and neurological disorders, as well as and other diseases involving cannabinoid neurotransmission. The compounds have the general formula (I), wherein R and R1-R4 have the meanings given in the specification.
    Type: Grant
    Filed: September 2, 2008
    Date of Patent: May 20, 2014
    Assignee: Solvay Pharmaceuticals, B.V.
    Inventors: Cornelis G. Kruse, Josephus H. M. Lange, Arnoldus H. J. Herremans, Herman H. Van Stuivenberg
  • MUSCARINIC AGONISTS TO TREAT IMPULSE CONTROL DISORDERS
    Publication number: 20100120752
    Abstract: The invention relates to a novel use of compounds and pharmaceutically acceptable salts thereof, which are muscarinic, for example muscarine-1 (M1) agonists. These compounds are useful for the preparation of medicaments for treatment, amelioration or prevention of impulse control disorders. These include impulse control disorders ‘Not Elsewhere Classified,’ such as intermittent explosive disorder, pyromania, kleptomania, pathological gambling and trichotillomania, and impulse control disorders ‘Not Otherwise Specified,’ such as compulsive buying disorder, binge eating and binge drinking disorder, impulsive self-injurious behavior, sexual addictions, compulsive Internet use, and excessive mobile phone use.
    Type: Application
    Filed: January 20, 2010
    Publication date: May 13, 2010
    Inventors: Natasja M.W.J. De Bruin, Marlies L. Van Drimmelen, Arnoldus H.J. Herremans, Martinus Th.M. Tulp, Cornelis G. Kruse
  • 4,5-dihydro-1H-pyrazole derivatives having potent CB-antagonistic activity
    Patent number: 7608718
    Abstract: The present invention relates to a group of novel 4,5-dihydro-1H-pyrazole derivatives which are potent cannabinoid (CB1) receptor antagonists with utility for the treatment of diseases connected with disorders of the cannabinoid system. The compounds have the general formula (Ia) or (Ib) wherein the symbols have the meanings given in the specification. The invention also relates to methods for the preparation of these compounds, and to pharmaceutical compositions containing one or more of these compounds as an active component.
    Type: Grant
    Filed: November 3, 2005
    Date of Patent: October 27, 2009
    Assignee: Solvay Pharmaceuticals B.V.
    Inventors: Josephus H. M. Lange, Cornelis G. Kruse, Jacobus Tipker, Herman H. van Stuivenberg, Arnoldus H. J. Herremans
  • 1H-IMIDAZOLE DERIVATIVE HAVING CB1, AGONISTIC, CB1 PARTIAL AGONISTIC OR CB1 ANTAGNISTIC ACTIVITY
    Publication number: 20090181949
    Abstract: The present invention relates to a group of novel 1H-imidazole derivatives, to methods for the preparation of these compounds, and to pharmaceutical compositions containing one or more of these compounds as an active component. These 1H-imidazole derivatives are potent cannabinoid-CB1 receptor agonists, partial agonists or antagonists, useful for the treatment of psychiatric and neurological disorders, as well as and other diseases involving cannabinoid neurotransmission. The compounds have the general formula (I) wherein R and R1-R4 have the meanings given in the specification.
    Type: Application
    Filed: September 2, 2008
    Publication date: July 16, 2009
    Inventors: Cornelis G. KRUSE, Josephus H.M. LANGE, Arnoldus H.J. HERREMANS, Herman H. VAN STUIVENBERG
  • 4,5-dihydro-1H-pyrazole derivatives having CB-antagonistic activity
    Patent number: 7528162
    Abstract: The present invention relates to a group of novel 4,5-dihydro-1H-pyrazole derivatives which are potent cannabinoid (CB1) receptor antagonists with utility for the treatment of diseases connected with disorders of the cannabinoid system. The compounds have the general formula (I) wherein the symbols have the meanings given in the specification. The invention also relates to methods for the preparation of these compounds, and to pharmaceutical compositions containing one or more of these compounds as an active component.
    Type: Grant
    Filed: September 17, 2002
    Date of Patent: May 5, 2009
    Assignee: Solvay Pharmaceuticals, B.V.
    Inventors: Cornelis G. Kruse, Josephus H. M. Lange, Jacobus Tipker, Arnoldus H. J. Herremans, Herman H. Van Stuivenberg
  • USE OF 5-HT6 ANTAGONISTS TO PREVENT RELAPSE INTO ADDICTION
    Publication number: 20080171779
    Abstract: A novel use of compounds and pharmaceutically acceptable salts thereof, which are 5-HT6 antagonists, are disclosed. In one embodiment, the invention relates to the use of these compounds or pharmaceutical compositions comprising these compounds for preventing relapse into addiction, for example, relapse into addiction to substances of abuse, including opiates, hallucinogens, inhalants, phencyclidine, amphetamines, cocaine, cannabis, nicotine, and alcohol, relapse into addiction to certain medicines, including sedatives, hypnotics and anxiolytics, and relapse into certain addictive behaviors, including gambling.
    Type: Application
    Filed: January 14, 2008
    Publication date: July 17, 2008
    Inventors: Natasja M.W.J. De Bruin, Arnold Van Loevezijn, Johan Wijnen, Arnoldus H.J. Herremans, Cornelis G. Kruse
  • Thiazole derivatives having CB-antagonistic, agonistic or partial agonistic activity
    Patent number: 7342032
    Abstract: Computer game systems respond to the spatial state of a pointing device. Changes in the spatial state of a hand held or mobile unit, or plurality of units drive a game scheme maintained in a computer. Position and attitude of the mobile device cause program branching functions which are bases upon a game rule set. In example, a game scheme executed on a computing apparatus may be incorporated into a mobile telephone having a GPS and electronic compass. Physical states relating to position and pointing attitude of the telephone as described in part by position or attitude parameters, drives computer programming code to takes actions which depend on measured position and attitude values thus making computer games for mobile users are made highly interactive. User gestures including simple pointing actions allow a user to express desires to a computer in an express and direct fashion.
    Type: Grant
    Filed: March 17, 2003
    Date of Patent: March 11, 2008
    Assignee: Solvay Pharmaceuticals, Inc.
    Inventors: Josephus H. M. Lange, Cornelis G. Kruse, Arnoldus H. J. Herremans, Herman H. van Stuivenberg, Jessica A. R. Dijksman, Andrew C. McCreary
  • MUSCARINIC AGONISTS TO TREAT IMPULSE CONTROL DISORDERS
    Publication number: 20070259859
    Abstract: The invention relates to a novel use of compounds and pharmaceutically acceptable salts thereof, which are muscarinic, for example muscarine-1 (M1) agonists. These compounds are useful for the preparation of medicaments for treatment, amelioration or prevention of impulse control disorders. These include impulse control disorders ‘Not Elsewhere Classified,’ such as intermittent explosive disorder, pyromania, kleptomania, pathological gambling and trichotillomania, and impulse control disorders ‘Not Otherwise Specified,’ such as compulsive buying disorder, binge eating and binge drinking disorder, impulsive self-injurious behavior, sexual addictions, compulsive Internet use, and excessive mobile phone use.
    Type: Application
    Filed: April 30, 2007
    Publication date: November 8, 2007
    Inventors: Natasja M.W.J. De Bruin, Marlies L. Van Drimmelen, Arnoldus H.J. Herremans, Martinus Th.M. Tulp, Cornelis G. Kruse
  • 1H-imidazole derivatives having CB1 agonistic, CB1 partial agonistic or CB1-antagonistic activity
    Patent number: 7109216
    Abstract: The present invention relates to a group of novel 1H-imidazole derivatives, to methods for the preparation of these compounds, and to pharmaceutical compositions containing one or more of these compounds as an active component. These 1H-imidazole derivatives are potent cannabinoid-CB1 receptor agonists, partial agonists or antagonists, useful for the treatment of psychiatric and neurological disorders, as well as and other diseases involving cannabinoid neurotransmission. The compounds have the general formula (I) wherein R and R1–R4 have the meanings given in the specification.
    Type: Grant
    Filed: August 6, 2004
    Date of Patent: September 19, 2006
    Assignee: Solvay Pharmaceuticals B.V.
    Inventors: Cornelis G. Kruse, Josephus H. M. Lange, Arnoldus H. J. Herremans, Herman H. van Stuivenberg
  • Piperazine oxime dervatives having NK-1 receptor antagonistic activity
    Patent number: 7094779
    Abstract: The present invention relates to a group of novel piperazine oxime derivatives having interesting NK-1 antagonistic activity.
    Type: Grant
    Filed: July 3, 2002
    Date of Patent: August 22, 2006
    Assignee: Solvay Pharmaceuticals B.V.
    Inventors: Wouter I. Iwema Bakker, Jan H. van Maarseveen, Hein K. A. C. Coolen, Martinus Th. M. Tulp, Arnoldus H. J. Herremans, Andrew C. Mccreary, Gustaaf J. M. van Scharrenburg, Adrianus van den Hoogenband
  • 4,5-Dihydro-1H-pyrazole derivatives having potent CB1-antagonistic activity
    Patent number: 6974810
    Abstract: The present invention relates to a group of novel 4,5-dihydro-1H-pyrazole derivatives which are potent cannabinoid (CB1) receptor antagonists with utility for the treatment of diseases connected with disorders of the cannabinoid system. The compounds have the general formula (Ia) or (Ib) wherein the symbols have the meanings given in the specification.
    Type: Grant
    Filed: September 17, 2002
    Date of Patent: December 13, 2005
    Assignee: Solvay Pharmaceuticals B.V.
    Inventors: Josephus H. M. Lange, Cornelis G. Kruse, Jacobus Tipker, Herman H. van Stuivenberg, Arnoldus H. J. Herremans
  • Thiazole derivatives having cb1-antagonistic, agonistic or partial agonistic activity
    Publication number: 20040266841
    Abstract: The present invention relates to a group of thiazoloe derivatives which are potent antagonist, agonists or partial agonist of the cannabinoid CB1-receptor.
    Type: Application
    Filed: March 23, 2004
    Publication date: December 30, 2004
    Inventors: Josephus H.M. Lange, Cornelis G. Kruse, Arnoldus H.J. Herremans, Herman H. van Stuivenberg, Jessica A.R. Dijksman, Andrew C. McCreary
  • Novel 4,5-dihydro-1h-pyrazole derivatives having cb1-antagonistic activity
    Publication number: 20040248944
    Abstract: The present invention relates to a group of novel 4,5-dihydro-1H-pyrazo, derivatives which are potent cannabinoid (CB1) receptor antagonists with utility for the treatment of diseases connected with disorders of the cannabinoid system. The compounds have the general formula (I) wherein the symbols have the meanings given in the specification. The invention also relates to methods for the preparation of these compounds, and to pharmaceutical compositions containing one or more of these compounds as an active component.
    Type: Application
    Filed: March 22, 2004
    Publication date: December 9, 2004
    Inventors: Cornelis G Kruse, Josephus H. M. Lange, Jacobus Tipker, Arnoldus H.J. Herremans, Herman H. Van Stuivenberg
  • 1H-imidazole derivatives having cb1 agonistic, cb1 partial agonistic or cb1 antagonistic activity
    Publication number: 20040235854
    Abstract: The present invention relates to a group of novel 1H-imidazole derivatives, to methods for the preparation of these compounds, and to pharmaceutical compositions containing one or more of these compounds as an active component. These 1H-imidazole derivatives are potent cannabinoid-CB1 receptor agonists, partial agonists or antagonists, useful for the treatment of psychiatric and neurological disorders, as well as and other diseases involving cannabinoid neurotransmission. The compounds have the general formula (I) wherein R and R1-R4 have the meanings given in the specification.
    Type: Application
    Filed: March 19, 2004
    Publication date: November 25, 2004
    Inventors: Cornelis G. Kruse, Josephus H.M. Lange, Arnoldus H.J. Herremans, Herman H. Van Stuivenberg
  • Piperazine oxime dervatives having nk-1 receptor antagonistic activity
    Publication number: 20040176389
    Abstract: The present invention relates to a group of novel piperazine oxime derivatives having interesting NK-1 antagonistic activity.
    Type: Application
    Filed: December 12, 2003
    Publication date: September 9, 2004
    Inventors: Wouter I Ivema Bakker, Jan H van Maarseveen, Hein K A C Coolen, Martinus Th M Tulp, Arnoldus H J Herremans, Andrew C Mccreary, Gustaaf J M van Scharrenburg, Adrianus van den Hoogenband