Patents by Inventor Arnulf Staib

Arnulf Staib has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220170769
    Abstract: The present disclosure provides for a sensor system for determining a flow rate of a fluid flow within a fluid channel comprising an elastic segment arranged next to a rigid segment, wherein a first pair of electrodes is provided at the rigid segment and a second pair of electrodes is provided at the elastic segment of the fluid channel. The system further comprises a sensor unit for detecting a capacitance of the first and second electrode pairs, and a processing unit for calculating and monitoring a distance between the electrodes of the second electrode pair based on the detected capacitance of the first electrode pair and the second electrode pair, wherein the first electrode pair is in contact with the rigid segment and the second electrode pair is in contact with the elastic segment. Moreover, a respective method for determining a flow rate of a fluid flow within a fluid channel is provided by the present disclosure, as well as a use of the sensor system.
    Type: Application
    Filed: November 30, 2021
    Publication date: June 2, 2022
    Inventors: Sven Ebert, Michal Karol Dobrzynski, Paul Federer, Arnulf Staib, Lukas Schneider
  • Publication number: 20210349108
    Abstract: The present invention relates to a method for detecting and in particular for measuring C-peptide. Specifically, the present invention relates to a displacement assay for quantitative determination of C-peptide in a sample.
    Type: Application
    Filed: October 15, 2019
    Publication date: November 11, 2021
    Applicant: Roche Diabetes Care GmbH
    Inventors: Arnulf Staib, Alexander Licht, Daniel Kammerer
  • Patent number: 10892040
    Abstract: A method is provided for evaluating a set of measurement data from an oral glucose tolerance test. The method may include calculating a similarity measure that quantifies the similarity between a time profile of the series of measured data of the glucose concentration and a corresponding glucose reference profile. The method may include calculating a further similarity measure that quantifies the similarity between the profile of the series of measured values of the further analyte concentration and the corresponding analyte sample profile, wherein the data set is represented by a point in a vector space that comprises coordinate axes that are formed by the similarity measures, whereby the coordinates of said point contain the calculated values of the similarity measures.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: January 12, 2021
    Assignee: ROCHE DIABETES CARE, INC.
    Inventors: Arnulf Staib, Ortrud Quarder, Gerhard Werner
  • Patent number: 10422765
    Abstract: Electrode systems are disclosed for measuring the concentration of an analyte under in vivo conditions, where the systems includes an electrode with immobilized enzyme molecules and an improved diffusion barrier that controls diffusion of the analyte from body fluid surrounding the electrode system to the enzyme molecules. Methods of making and using the system also are disclosed.
    Type: Grant
    Filed: September 16, 2013
    Date of Patent: September 24, 2019
    Assignee: ROCHE DIABETES CARE, INC.
    Inventors: Arnulf Staib, Marcel Thiele, Karl-Heinz Koelker, Ewald Rieger
  • Patent number: 10390743
    Abstract: Electrode systems are disclosed for measuring the concentration of an analyte under in-vivo conditions, where such systems include a counter electrode having an electrical conductor, a working electrode having an electrical conductor on which an enzyme layer containing immobilized enzyme molecules for catalytic conversion of the analyte is arranged, and a diffusion barrier that slows the diffusion of the analyte from body fluid surrounding the electrode system to enzyme molecules. The enzyme layer is in the form of multiple fields that are arranged on the conductor of the working electrode at a distance from each other.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: August 27, 2019
    Assignee: ROCHE DIABETES CARE, INC.
    Inventors: Ewald Rieger, Reinhold Mischler, Ortrud Quarder, Arnulf Staib, Ulrike Kamecke, Ralph Gillen
  • Patent number: 10330627
    Abstract: Biosensors and biosensor systems are disclosed that have manganese (III) oxide (Mn2O3)-based electrodes that can attenuate interference of a detection signal resulting from an analyte-relevant reaction caused by undesired reaction of interferents in a sample. Methods are also disclosed for making and using the same.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: June 25, 2019
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Karl-Heinz Koelker, Arnulf Staib
  • Patent number: 10194839
    Abstract: The invention relates to a method for assessment of a series of glucose concentration values of a body fluid of a diabetic for adjustment of the dosing of insulin administrations as well as a suitable device for carrying out the method.
    Type: Grant
    Filed: June 5, 2006
    Date of Patent: February 5, 2019
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Arnulf Staib, Hans-Martin Klötzer
  • Patent number: 10111609
    Abstract: The invention relates to a method for detecting a malfunction of a sensor for measuring an analyte concentration in vivo, wherein a series of measurement signals is produced by means of the sensor, and a value of a noise parameter is continually determined from the measuring signals, the noise parameter indicating how severely the measurement is impaired by interference signals. According to the invention, continually determined values of the noise parameter are used to determine how quickly the noise parameter changes, and the rate of change of the noise parameter is evaluated to detect a malfunction.
    Type: Grant
    Filed: November 30, 2015
    Date of Patent: October 30, 2018
    Assignee: ROCHE DIABETES CARE, INC.
    Inventors: Guenther Schmelzeisen-Redeker, Arnulf Staib, Hans-Martin Kloetzer
  • Publication number: 20170290538
    Abstract: An in vivo amperometric sensor is provided for measuring the concentration of an analyte in a body fluid. The sensor comprises a counter electrode and a working electrode, and the working electrode comprises a sensing layer which is generally water permeable and arranged on a support member adjacent to a contact pad. The sensing layer comprises an immobilized enzyme capable of acting catalytically in the presence of the analyte to cause an electrical signal. The sensing layer has an upper surface facing the body fluid and a lower surface facing away from the body fluid, and the immobilized enzyme is distributed within the sensing layer in such a way that the enzyme concentration in the middle between the upper and lower surfaces is at least as high as on the upper surface of the sensing layer.
    Type: Application
    Filed: June 23, 2017
    Publication date: October 12, 2017
    Inventors: Arnulf Staib, Reinhold Mischler, Martin Hajnsek, Harvey Buck, Walter Jernigan
  • Publication number: 20170277865
    Abstract: A method is provided for evaluating a set of measurement data from an oral glucose tolerance test. The method may include calculating a similarity measure that quantifies the similarity between a time profile of the series of measured data of the glucose concentration and a corresponding glucose reference profile. The method may include calculating a further similarity measure that quantifies the similarity between the profile of the series of measured values of the further analyte concentration and the corresponding analyte sample profile, wherein the data set is represented by a point in a vector space that comprises coordinate axes that are formed by the similarity measures, whereby the coordinates of said point contain the calculated values of the similarity measures.
    Type: Application
    Filed: June 9, 2017
    Publication date: September 28, 2017
    Applicant: Roche Diabetes Care, Inc.
    Inventors: Arnulf Staib, Ortrud Quarder, Gerhard Werner
  • Patent number: 9700252
    Abstract: An in vivo amperometric sensor is provided for measuring the concentration of an analyte in a body fluid. The sensor comprises a counter electrode and a working electrode, and the working electrode comprises a sensing layer which is generally water permeable and arranged on a support member adjacent to a contact pad. The sensing layer comprises an immobilized enzyme capable of acting catalytically in the presence of the analyte to cause an electrical signal. The sensing layer has an upper surface facing the body fluid and a lower surface facing away from the body fluid, and the immobilized enzyme is distributed within the sensing layer in such a way that the enzyme concentration in the middle between the upper and lower surfaces is at least as high as on the upper surface of the sensing layer.
    Type: Grant
    Filed: August 2, 2013
    Date of Patent: July 11, 2017
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Arnulf Staib, Reinhold Mischler, Martin Hajnsek, Harvey Buck, Walter Jernigan
  • Publication number: 20170000396
    Abstract: An in vivo amperometric sensor is provided for measuring the concentration of an analyte in a body fluid. The sensor comprises a counter electrode and a working electrode, and the working electrode comprises a sensing layer which is generally water permeable and arranged on a support member adjacent to a contact pad. The sensing layer comprises an immobilized enzyme capable of acting catalytically in the presence of the analyte to cause an electrical signal. The sensing layer has an upper surface facing the body fluid and a lower surface facing away from the body fluid, and the immobilized enzyme is distributed within the sensing layer in such a way that the enzyme concentration in the middle between the upper and lower surfaces is at least as high as on the upper surface of the sensing layer.
    Type: Application
    Filed: August 2, 2013
    Publication date: January 5, 2017
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Arnulf Staib, Reinhold Mischler, Martin Hajnsek, Harvey Buck, Walter Jernigan
  • Publication number: 20160296151
    Abstract: Electrode systems are disclosed for measuring the concentration of an analyte under in-vivo conditions, where such systems include a counter electrode having an electrical conductor, a working electrode having an electrical conductor on which an enzyme layer containing immobilized enzyme molecules for catalytic conversion of the analyte is arranged, and a diffusion barrier that slows the diffusion of the analyte from body fluid surrounding the electrode system to enzyme molecules. The enzyme layer is in the form of multiple fields that are arranged on the conductor of the working electrode at a distance from each other.
    Type: Application
    Filed: June 17, 2016
    Publication date: October 13, 2016
    Inventors: Ewald Rieger, Reinhold Mischler, Ortrud Quarder, Arnulf Staib, Ulrike Kamacke, Ralph Dillen
  • Patent number: 9394563
    Abstract: An electrode system for measuring the concentration of an analyte under in-vivo conditions comprises a counter-electrode having an electrical conductor, a working electrode having an electrical conductor on which an enzyme layer containing immobilized enzyme molecules for catalytic conversion of the analyte is arranged, and a diffusion barrier that slows the diffusion of the analyte from body fluid surrounding the electrode system to enzyme molecules. The enzyme layer is in the form of multiple fields that are arranged on the conductor of the working electrode at a distance from each other.
    Type: Grant
    Filed: March 8, 2011
    Date of Patent: July 19, 2016
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Ortrud Quarder, Arnulf Staib, Reinhold Mischler, Ewald Rieger, Ralph Gillen, Ulrike Kamecke
  • Publication number: 20160081596
    Abstract: The invention relates to a method for detecting a malfunction of a sensor for measuring an analyte concentration in vivo, wherein a series of measurement signals is produced by means of the sensor, and a value of a noise parameter is continually determined from the measuring signals, the noise parameter indicating how severely the measurement is impaired by interference signals. According to the invention, continually determined values of the noise parameter are used to determine how quickly the noise parameter changes, and the rate of change of the noise parameter is evaluated to detect a malfunction.
    Type: Application
    Filed: November 30, 2015
    Publication date: March 24, 2016
    Inventors: Guenther Schmelzeisen-Redeker, Arnulf Staib, Hans-Martin Kloetzer
  • Publication number: 20150038814
    Abstract: An in vivo amperometric sensor is provided for measuring the concentration of an analyte in a body fluid. The sensor comprises a counter electrode and a working electrode, and the working electrode comprises a sensing layer which is generally water permeable and arranged on a support member adjacent to a contact pad. The sensing layer comprises an immobilized enzyme capable of acting catalytically in the presence of the analyte to cause an electrical signal. The sensing layer has an upper surface facing the body fluid and a lower surface facing away from the body fluid, and the immobilized enzyme is distributed within the sensing layer in such a way that the enzyme concentration in the middle between the upper and lower surfaces is at least as high as on the upper surface of the sensing layer.
    Type: Application
    Filed: August 2, 2013
    Publication date: February 5, 2015
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Arnulf Staib, Reinhold Mischler, Martin Hajnsek, Harvey Buck, Walter Jernigan
  • Patent number: 8942778
    Abstract: The invention generally relates to a sensor system. In particular to a sensor for glucose monitoring. The invention also also relates to an arrangement and a method for monitoring a constituent and in particular glucose in body tissue using a sensor system.
    Type: Grant
    Filed: May 18, 2011
    Date of Patent: January 27, 2015
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Gregor Ocvirk, Helmut Rinne, Arnulf Staib
  • Publication number: 20150005605
    Abstract: An electrode system is disclosed for measuring a concentration or presence of an analyte under in-vivo conditions, where the electrode system includes at least one electrode with immobilized enzyme molecules and an improved diffusion barrier that controls diffusion of the analyte from body fluid surrounding the electrode system to the enzyme molecules. The diffusion barrier includes a hydrophilic polyurethane or a block copolymer having at least one hydrophilic block and at least one hydrophobic block. The electrode system also can include a spacer membrane that includes a hydrophilic copolymer of acrylic and/or methacrylic monomers.
    Type: Application
    Filed: September 15, 2014
    Publication date: January 1, 2015
    Inventors: Arnulf Staib, Marcel Thiele, Karl-Heinz Koelker, Ewald Rieger
  • Patent number: 8871068
    Abstract: The disclosure concerns a high efficiency electrochemical sensor with high signal yield for determining an analyte in a fluid medium comprising, at least one reference electrode, at least one working electrode having particles of an electrocatalyst in an electrode matrix, and an enzyme that is suitable for determining an analyte is selectively covalently bound to the particles of the electrocatalyst. The disclosure also describes a process for producing the electrochemical sensor and a method for determining an analyte in a fluid medium using the electrochemical sensor. have a high efficiency and thus achieve a high signal yield.
    Type: Grant
    Filed: July 18, 2008
    Date of Patent: October 28, 2014
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Arnulf Staib, Thomas Meier, Reinhold Mischler, Harald Peschel, Martin Hajnsek
  • Publication number: 20140251826
    Abstract: Biosensors and biosensor systems are disclosed that have manganese (III) oxide (Mn2O3)-based electrodes that can attenuate interference of a detection signal resulting from an analyte-relevant reaction caused by undesired reaction of interferents in a sample. Methods are also disclosed for making and using the same.
    Type: Application
    Filed: March 6, 2014
    Publication date: September 11, 2014
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Karl-Heinz Koelker, Arnulf Staib