Patents by Inventor Aroesti-Assi Simaan

Aroesti-Assi Simaan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CD11 B[low] MACROPHAGES AND CONDITIONED MEDIA THEREOF FOR TREATING CANCER AND/OR FIBROSIS
    Publication number: 20170340670
    Abstract: A conditioned cell culture medium of CD11blow human macrophages or a biologically active fraction thereof can be prepared by a method that includes (i) culturing a population of human mononuclear cells of the monocyte/macrophage lineage for 5-7 days, so as to induce differentiation of the mononuclear cells to macrophages; (ii) incubating the macrophages obtained in (i) with apoptotic cells or in the presence of a pro-resolving lipid mediator to reduce the CD11b expression, thus obtaining a culture of CD11blow macrophages; and (iii) collecting the conditioned cell culture medium of CD11blow macrophages. Pharmaceutical compositions containing the CD11blow macrophages conditioned medium or a culture of CD11blow macrophages can be used in the treatment of cancer or fibrosis.
    Type: Application
    Filed: August 1, 2017
    Publication date: November 30, 2017
    Inventors: Dalit Barkan, Odelya Gilon, Amiram Ariel, Sagie Schif-Zuck, Aroesti-Assi Simaan
  • CD11 B[low] macrophages and conditioned media thereof for treating cancer and/or fibrosis
    Patent number: 9724366
    Abstract: A conditioned medium of CD11blow macrophages and methods for preparing it are provided. Pharmaceutical compositions comprising the CD11blow macrophages conditioned medium or a culture of CD11blow macrophages and their use in the treatment of cancer or fibrosis are also provided.
    Type: Grant
    Filed: December 30, 2013
    Date of Patent: August 8, 2017
    Assignee: Carmel-Haifa University Economic Corporation Ltd
    Inventors: Dalit Barkan, Odelya Gilon, Amiram Ariel, Sagie Schif-Zuck, Aroesti-Assi Simaan