Patents by Inventor Aron Anderson

Aron Anderson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20080081064
    Abstract: An implantable medical device for the release of bioactive agents at desired rates is described. The device includes a body member with two or more aperture sets and an inner space. The bioactive agents are arranged within the inner space of the body member so that each bioactive agent present in the inner space is individually releasable through their respective aperture set. The aperture sets modulate the release of the bioactive agents from the body member. Arrangement of apertures and bioactive agents within the inner portion chosen to provide desired and independent release rates from the device.
    Type: Application
    Filed: September 28, 2007
    Publication date: April 3, 2008
    Inventors: Bruce Jelle, John Wall, Aron Anderson
  • Publication number: 20080038354
    Abstract: The present invention is directed to polymeric matrices for the controlled release of a hydrophilic bioactive agent. Generally, the elution control matrix includes a polymeric matrix having a first polymer and a plurality of microparticles that include the hydrophilic bioactive agent. In one embodiment, the matrix includes a polymer comprising hydrophilic and hydrophobic portions. In another embodiment, the microparticles include a crosslinked hydrophilic polymer.
    Type: Application
    Filed: June 28, 2007
    Publication date: February 14, 2008
    Inventors: Joram Slager, Aron Anderson
  • Publication number: 20070275027
    Abstract: Polymeric matrices including microparticles that provide sustained release of a hydrophilic bioactive agent are described. The matrices can be in the form of a coating on the surface of an implantable medical article or an in situ formed matrix. The microparticles of the matrix include a first polymer and a second polymer that modulates release of the hydrophilic bioactive agent from the matrix.
    Type: Application
    Filed: January 12, 2007
    Publication date: November 29, 2007
    Inventors: Jie Wen, Aron Anderson
  • Publication number: 20070104757
    Abstract: A reagent and related method for use in passivating a biomaterial surface, the reagent including a latent reactive group and a bifunctional aliphatic acid (e.g., fatty acid), in combination with a spacer group linking the latent reactive group to the aliphatic acid in a manner that preserves the desired function of each group. Once bound to the surface, via the latent reactive group, the reagent presents the aliphatic acid to the physiological environment, in vivo, in a manner (e.g., concentration and orientation) sufficient to hold and orient albumin.
    Type: Application
    Filed: October 6, 2006
    Publication date: May 10, 2007
    Inventors: Patrick Guire, Aron Anderson, Richard Amos, Terrence Everson, Peter Duquette
  • Publication number: 20070082022
    Abstract: A reagent and related method for use in passivating a biomaterial surface, the reagent including a latent reactive group and a bifunctional aliphatic acid (e.g., fatty acid), in combination with a spacer group linking the latent reactive group to the aliphatic acid in a manner that preserves the desired function of each group. Once bound to the surface, via the latent reactive group, the reagent presents the aliphatic acid to the physiological environment, in vivo, in a manner (e.g., concentration and orientation) sufficient to hold and orient albumin.
    Type: Application
    Filed: October 6, 2006
    Publication date: April 12, 2007
    Inventors: Patrick Guire, Aron Anderson, Richard Amos, Terrence Everson, Peter Duquette
  • Publication number: 20060216324
    Abstract: The invention provides methods and compositions for providing biocompatible surfaces to medical articles. In particular the invention provides biocompatible coatings with heparin activity. In some aspects, the biocompatible coatings of the invention are able to release a bioactive agent. The coatings can be formed using biostable or biodegradable polymeric material and photoreactive groups. The invention also provides methods for improving the quality of bioactive agent-containing coatings by performing pre-irradiation of biocompatible coating compositions.
    Type: Application
    Filed: May 25, 2006
    Publication date: September 28, 2006
    Inventors: Sean Stucke, Ralph Chappa, Joseph Chinn, Aron Anderson
  • Publication number: 20060067968
    Abstract: A coating composition for use in coating implantable medical devices to improve their ability to release bioactive agents in vivo. The coating composition is particularly adapted for use with devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a mixture of a first polymer component such as poly(butyl methacrylate) and a second polymer component such as poly(ethylene-co-vinyl acetate).
    Type: Application
    Filed: November 17, 2005
    Publication date: March 30, 2006
    Inventors: Stephen Chudzik, Aron Anderson, Ralph Chappa, Timothy Kloke
  • Publication number: 20060052460
    Abstract: A reagent and related method for use in passivating a biomaterial surface, the reagent including a latent reactive group and a bifunctional aliphatic acid (e.g., fatty acid), in combination with a spacer group linking the latent reactive group to the aliphatic acid in a manner that preserves the desired function of each group. Once bound to the surface, via the latent reactive group, the reagent presents the aliphatic acid to the physiological environment, in vivo, in a manner (e.g., concentration and orientation) sufficient to hold and orient albumin.
    Type: Application
    Filed: August 26, 2005
    Publication date: March 9, 2006
    Inventors: Patrick Guire, Aron Anderson, Richard Amos, Terrence Everson, Peter Duquette
  • Publication number: 20060034891
    Abstract: The invention provides implantable medical devices that are fabricated, at least in part, from biodegradable polymeric material. The implantable medical devices are used to provide bioactive agent to a treatment site, and are particularly useful for treatment of limited access regions of the body.
    Type: Application
    Filed: July 5, 2005
    Publication date: February 16, 2006
    Inventors: Laurie Lawin, Aron Anderson
  • Publication number: 20060024350
    Abstract: The invention provides implantable medical devices that are fabricated of biodegradable materials for delivery of bioactive agent to limited access regions of a patient's body, such as the eye. The invention further provides methods of treatment utilizing the devices.
    Type: Application
    Filed: June 24, 2005
    Publication date: February 2, 2006
    Inventors: Signe Varner, Patrick Guire, Kristin Taton, Jie Wen, Nathan Beeley, Laurie Lawin, Robert Hergenrother, Ralph Chappa, Aron Anderson
  • Publication number: 20060018948
    Abstract: The invention provides implantable intraluminal medical devices that are fabricated of biodegradable materials. The invention further provides methods of treatment utilizing the devices.
    Type: Application
    Filed: June 24, 2005
    Publication date: January 26, 2006
    Inventors: Patrick Guire, Kristin Taton, Jie Wen, David DeWitt, Robert Hergenrother, Aron Anderson
  • Publication number: 20060013835
    Abstract: The invention provides a controlled release bioactive agent delivery device for treatment of an eye that includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension, and a polymeric coated composition in contact with a surface of the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent. The first polymer and the second polymer are hydrophobic, and the body member has a length such that, upon placement of the device at an implantation site within a posterior segment of an eye, the device does not enter a central visual field of the eye. The invention also provides methods method of delivering bioactive agent to a posterior region of an eye.
    Type: Application
    Filed: September 12, 2005
    Publication date: January 19, 2006
    Inventors: Aron Anderson, Laurie Lawin, Byron Shen, Eugene de Juan, Signe Varner, Ralph Chappa
  • Publication number: 20050287188
    Abstract: The invention provides retrievable devices for sustained delivery of bioactive agent to a site within a patient, the devices including a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension; a cap at the proximal end of the body member; and a polymeric coated composition in contact with a surface of the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent.
    Type: Application
    Filed: August 15, 2005
    Publication date: December 29, 2005
    Inventors: Aron Anderson, Laurie Lawin, Byron Shen, Eugene de Juan, Signe Varner, Ralph Chappa
  • Publication number: 20050281863
    Abstract: The invention provides controlled release bioactive agent delivery devices that include a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension, and a polymeric coated composition in contact with the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent, wherein the first polymer and the second polymer are hydrophobic. The invention also provides methods of delivering a bioactive agent to a patient in a controlled release manner, as well as methods of making controlled release bioactive agent delivery devices.
    Type: Application
    Filed: August 15, 2005
    Publication date: December 22, 2005
    Inventors: Aron Anderson, Laurie Lawin, Byron Shen, Eugene de Juan, Signe Varner, Ralph Chappa
  • Publication number: 20050276837
    Abstract: The invention provides a controlled release bioactive agent delivery device that includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension, and a polymeric coated composition in contact with the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent. The invention also provides methods of delivering a bioactive agent to a patient in a controlled release manner, as well as methods of making a controlled release bioactive agent delivery device.
    Type: Application
    Filed: August 15, 2005
    Publication date: December 15, 2005
    Inventors: Aron Anderson, Laurie Lawin, Byron Shen, Eugene de Juan, Signe Varner, Ralph Chappa
  • Publication number: 20050271706
    Abstract: The invention provides methods for delivering bioactive agent to an eye, the methods including steps of providing a device at an implantation site within the eye, and maintaining the device at the implantation site to provide a therapeutically effective amount of the bioactive agent to the eye. The device includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension. A polymeric coated composition is provided in contact with a surface of the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent. The invention also provides methods of administering a therapeutically effective amount of bioactive agent to a posterior segment of an eye.
    Type: Application
    Filed: August 15, 2005
    Publication date: December 8, 2005
    Inventors: Aron Anderson, Laurie Lawin, Byron Shen, Eugene Juan, Signe Varner, Ralph Chappa
  • Publication number: 20050271703
    Abstract: The invention provides implantable sustained release bioactive agent delivery devices that include a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension; and a polymeric coated composition in contact with a surface of the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent. The polymeric coated composition is formulated to provide controlled release of bioactive agent over time when introduced into physiological conditions. Methods of preparing implantable devices configured and formulated to provide controlled release of bioactive agent are also provided.
    Type: Application
    Filed: August 15, 2005
    Publication date: December 8, 2005
    Inventors: Aron Anderson, Laurie Lawin, Byron Shen, Eugene de Juan, Signe Varner, Ralph Chappa
  • Publication number: 20050260246
    Abstract: A coating composition for use in coating implantable medical devices to improve their ability to release bioactive agents in vivo. The coating composition is particularly adapted for use with devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a mixture of a first polymer component such as poly(butyl methacrylate) and a second polymer component such as poly(ethylene-co-vinyl acetate).
    Type: Application
    Filed: May 6, 2005
    Publication date: November 24, 2005
    Inventors: Stephen Chudzik, Aron Anderson, Ralph Chappa, Timothy Kloke, Laurie Lawin, Klaus Wormuth
  • Publication number: 20050244453
    Abstract: The invention provides methods and compositions for providing biocompatible surfaces to medical articles. In particular the invention provides biocompatible coatings with heparin activity. In some aspects, the biocompatible coatings of the invention are able to release a bioactive agent. The coatings can be formed using biostable or biodegradable polymeric material and photoreactive groups. The invention also provides methods for improving the quality of bioactive agent-containing coatings by performing pre-irradiation of biocompatible coating compositions.
    Type: Application
    Filed: March 25, 2005
    Publication date: November 3, 2005
    Inventors: Sean Stucke, Ralph Chappa, Joseph Chinn, Aron Anderson
  • Publication number: 20050019371
    Abstract: The invention provides a controlled release bioactive agent delivery device that includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension, and a polymeric coated composition in contact with the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent, wherein the first polymer comprises polyalkyl(meth)acrylate, aromatic poly(meth)acrylate, or a combination of polyalkyl(meth)acrylate and aromatic poly(meth)acrylate, and wherein the second polymer comprises poly(ethylene-co-vinyl acetate). The invention also provides methods of delivering a bioactive agent to a patient in a controlled release manner, as well as methods of making a controlled release bioactive agent delivery device.
    Type: Application
    Filed: April 29, 2004
    Publication date: January 27, 2005
    Inventors: Aron Anderson, Laurie Lawin, Byron Shen, Eugene Juan, Signe Varner