Patents by Inventor Aron M. Geurts

Aron M. Geurts has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fumarylacetoacetate hydrolase (FAH)-deficient and immunodeficient rats and uses thereof
    Patent number: 11793178
    Abstract: Described herein are rats with a hepatic deficiency comprising decreased function, activity, or expression of an enzyme in the tyrosine catabolic pathway (such as fumarylacetoacetate hydrolase), and methods of using the same for in vivo engraftment and expansion of heterologous hepatocytes, such as human hepatocytes, analysis of human liver disease, and analysis of xenobiotics. Also disclosed is the use of immunodeficient rats for the engraftment and expansion of heterologous hepatocytes.
    Type: Grant
    Filed: August 30, 2019
    Date of Patent: October 24, 2023
    Assignee: Yecuris Corporation
    Inventors: John R. Bial, Elizabeth M. Wilson, Aron M. Geurts
  • FUMARYLACETOACETATE HYDROLASE (FAH)-DEFICIENT AND IMMUNODEFICIENT RATS AND USES THEREOF
    Publication number: 20200008406
    Abstract: Described herein are rats with a hepatic deficiency comprising decreased function, activity, or expression of an enzyme in the tyrosine catabolic pathway (such as fumarylacetoacetate hydrolase), and methods of using the same for in vivo engraftment and expansion of heterologous hepatocytes, such as human hepatocytes, analysis of human liver disease, and analysis of xenobiotics. Also disclosed is the use of immunodeficient rats for the engraftment and expansion of heterologous hepatocytes.
    Type: Application
    Filed: August 30, 2019
    Publication date: January 9, 2020
    Inventors: John R. Bial, Elizabeth M. Wilson, Aron M. Geurts
  • Fumarylacetoacetate hydrolase (Fah)-deficient and immunodeficient rats and uses thereof
    Patent number: 10470445
    Abstract: Described herein are rats with a hepatic deficiency comprising decreased function, activity, or expression of an enzyme in the tyrosine catabolic pathway (such as fumarylacetoacetate hydrolase), and methods of using the same for in vivo engraftment and expansion of heterologous hepatocytes, such as human hepatocytes, analysis of human liver disease, and analysis of xenobiotics. Also disclosed is the use of immunodeficient rats for the engraftment and expansion of heterologous hepatocytes.
    Type: Grant
    Filed: May 19, 2016
    Date of Patent: November 12, 2019
    Assignee: Yecuris Corporation
    Inventors: John R. Bial, Elizabeth M. Wilson, Aron M. Geurts
  • GENOME EDITING IN RATS USING ZINC-FINGER NUCLEASES
    Publication number: 20190062789
    Abstract: Disclosed herein are methods and compositions for genome editing of one or more loci in a rat, using fusion proteins comprising a zinc-finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
    Type: Application
    Filed: November 19, 2015
    Publication date: February 28, 2019
    Inventors: Xiaoxia Cui, Aron M. Geurts, Fyodor Urnov
  • FUMARYLACETOACETATE HYDROLASE (FAH)-DEFICIENT AND IMMUNODEFICIENT RATS AND USES THEREOF
    Publication number: 20160249591
    Abstract: Described herein are rats with a hepatic deficiency comprising decreased function, activity, or expression of an enzyme in the tyrosine catabolic pathway (such as fumarylacetoacetate hydrolase), and methods of using the same for in vivo engraftment and expansion of heterologous hepatocytes, such as human hepatocytes, analysis of human liver disease, and analysis of xenobiotics. Also disclosed is the use of immunodeficient rats for the engraftment and expansion of heterologous hepatocytes.
    Type: Application
    Filed: May 19, 2016
    Publication date: September 1, 2016
    Inventors: John R. Bial, Elizabeth M. Wilson, Aron M. Geurts
  • GENOME EDITING IN RATS USING ZINC-FINGER NUCLEASES
    Publication number: 20160068865
    Abstract: Disclosed herein are methods and compositions for genome editing of one or more loci in a rat, using fusion proteins comprising a zinc-finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
    Type: Application
    Filed: November 19, 2015
    Publication date: March 10, 2016
    Inventors: Xiaoxia Cui, Aron M. Geurts, Fyodor Urnov
  • Method of deleting an IgM gene in an isolated rat cell
    Patent number: 9206404
    Abstract: Disclosed herein are methods and compositions for genome editing of one or more loci in a rat, using fusion proteins comprising a zinc-finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
    Type: Grant
    Filed: December 3, 2009
    Date of Patent: December 8, 2015
    Assignees: Sangamo BioSciences, Inc., Sigma-Aldrich Co. LLC
    Inventors: Xiaoxia Cui, Aron M. Geurts, Fyodor Urnov
  • FUMARYLACETOACETATE HYDROLASE (FAH)-DEFICIENT AND IMMUNODEFICIENT RATS AND USES THEREOF
    Publication number: 20140373187
    Abstract: Described herein are rats with a hepatic deficiency comprising decreased function, activity, or expression of an enzyme in the tyrosine catabolic pathway (such as fumarylacetoacetate hydrolase), and methods of using the same for in vivo engraftment and expansion of heterologous hepatocytes, such as human hepatocytes, analysis of human liver disease, and analysis of xenobiotics. Also disclosed is the use of immunodeficient rats for the engraftment and expansion of heterologous hepatocytes.
    Type: Application
    Filed: August 24, 2012
    Publication date: December 18, 2014
    Applicant: Yecuris Corporation
    Inventors: John R. Bial, Elizabeth M. Wilson, Aron M. Geurts
  • METHOD AND MATERIALS FOR PRODUCING A GENETICALLY MODIFIED ANIMAL
    Publication number: 20140338007
    Abstract: Transgenic artiodactyls are described as well as methods of making and using such artiodactyls.
    Type: Application
    Filed: July 14, 2014
    Publication date: November 13, 2014
    Applicant: Recombinetics, Inc.
    Inventors: Scott C. Fahrenkrug, Daniel F. Carlson, Aron M. Geurts
  • Methods for producing genetically modified animals using hypermethylated transposons
    Patent number: 8785718
    Abstract: Methods of using hypermethylated transposons to create genetically modified animals that express interfering RNAs are described.
    Type: Grant
    Filed: October 5, 2012
    Date of Patent: July 22, 2014
    Assignee: Recombinetics, Inc.
    Inventors: Scott C. Fahrenkrug, Daniel F. Carlson, Aron M. Geurts
  • Method for producing a transgenic pig using a hyper-methylated transposon
    Patent number: 8309791
    Abstract: Transgenic artiodactyls are described as well as methods of making and using such artiodactyls.
    Type: Grant
    Filed: July 16, 2009
    Date of Patent: November 13, 2012
    Assignee: Recombinectics, Inc.
    Inventors: Scott C. Fahrenkrug, Daniel F. Carlson, Aron M. Geurts
  • Transposon system and methods of use
    Patent number: 8227432
    Abstract: The present invention is directed to improved transposons and transposases. The present invention also includes gene transfer systems, methods of using the transposons and transposases, and compositions including the transposons and transposases.
    Type: Grant
    Filed: April 22, 2003
    Date of Patent: July 24, 2012
    Assignee: Regents of the University of Minnesota
    Inventors: Perry B. Hackett, Karl J. Clark, Zongbin Cui, Adam J. Dupuy, Aron M. Geurts, Geyi Liu
  • Genome editing in rats using zinc-finger nucleases
    Publication number: 20100218264
    Abstract: Disclosed herein are methods and compositions for genome editing of one or more loci in a rat, using fusion proteins comprising a zinc-finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
    Type: Application
    Filed: December 3, 2009
    Publication date: August 26, 2010
    Inventors: Xiaoxia Cui, Aron M. Geurts, Fyodor Urnov
  • METHODS AND MATERIALS FOR PRODUCING TRANSGENIC ANIMALS
    Publication number: 20100146655
    Abstract: Transgenic artiodactyls are described as well as methods of making and using such artiodactyls.
    Type: Application
    Filed: July 16, 2009
    Publication date: June 10, 2010
    Inventors: SCOTT C. FAHRENKRUG, DANIEL F. CARLSON, ARON M. GEURTS
  • Transposon system and methods of use
    Publication number: 20040077572
    Abstract: The present invention is directed to improved transposons and transposases. The present invention also includes gene transfer systems, methods of using the transposons and transposases, and compositions including the transposons and transposases.
    Type: Application
    Filed: April 22, 2003
    Publication date: April 22, 2004
    Applicant: Regents of the University of Minnesota
    Inventors: Perry B. Hackett, Karl J. Clark, Zongbin Cui, Adam J. Dupuy, Aron M. Geurts, Geyi Liu