Abstract: Compact microscope apparatus and methods of use are disclosed. One apparatus includes a stage, a light source, an objective, a dichroic element, and an imaging sensor. The stage is configured to hold a sample thereon. The light source is configured to emit light toward the stage. The objective is positioned to focus light from the stage. The dichroic element is configured to pass or reflect respective ones of the light emitted by the light source and the light from the stage. The imaging sensor is positioned to receive the light from the stage. The stage, the light source, the objective, the dichroic element, and the imaging sensor are arranged such that they may be received within an enclosure having dimensions no longer than about 300 mm. The apparatus may include a clinostat operable to continuously rotate the components of the apparatus about an axis.