Patents by Inventor Arounaguiry Ambroise

Arounaguiry Ambroise has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polymeric benzyl carbonate-derivatives
    Patent number: 8962549
    Abstract: The present invention relates to polymeric derivatives, which can be conjugated to an amino-containing drug to improve its in vivo properties. The polymeric derivative can subsequently be released to yield the drug in its native form. Methods of preparing and using these polymeric derivatives and drug conjugates are described.
    Type: Grant
    Filed: January 13, 2014
    Date of Patent: February 24, 2015
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventors: Guohan Yang, Ton That Hai, Bennett Melnick, Paul Sanders, Cong Jiang, Catherine Quinn, Jie Li, Arounaguiry Ambroise, Larry R. Brown
  • POLYMERIC BENZYL CARBONATE-DERIVATIVES
    Publication number: 20140128445
    Abstract: The present invention relates to polymeric derivatives, which can be conjugated to an amino-containing drug to improve its in vivo properties. The polymeric derivative can subsequently be released to yield the drug in its native form. Methods of preparing and using these polymeric derivatives and drug conjugates are described.
    Type: Application
    Filed: January 13, 2014
    Publication date: May 8, 2014
    Applicants: Baxter Healthcare SA, Baxter International Inc.
    Inventors: Guohan Yang, Ton That Hai, Bennett Melnick, Paul Sanders, Cong Jiang, Catherine Quinn, Jie Li, Arounaguiry Ambroise, Larry R. Brown
  • Polymeric benzyl carbonate-derivatives
    Patent number: 8653131
    Abstract: The present invention relates to polymeric derivatives, which can be conjugated to an amino-containing drug to improve its in vivo properties. The polymeric derivative can subsequently be released to yield the drug in its native form. Methods of preparing and using these polymeric derivatives and drug conjugates are described.
    Type: Grant
    Filed: August 21, 2009
    Date of Patent: February 18, 2014
    Assignees: Baxter Healthcare S.A., Baxter International Inc.
    Inventors: Guohan Yang, Ton That Hai, Bennett P. Melnick, Paul Sanders, Cong Jiang, Catherine Quinn, Jie Li, Arounaguiry Ambroise, Larry R. Brown
  • Synthesis of phosphono-substituted porphyrin compounds for attachment to metal oxide surfaces
    Patent number: 8445695
    Abstract: A method of making a phosphono-substituted dipyrromethane comprises reacting an aldehyde or acetal having at least one phosphono group substituted thereon with pyrrole to produce a phosphono-substituted dipyrromethane; and wherein the phosphono is selected from the group consisting of dialkyl phosphono, diaryl phosphono, and dialkylaryl phosphono. Additional methods, intermediates and products are also described.
    Type: Grant
    Filed: August 29, 2012
    Date of Patent: May 21, 2013
    Assignees: North Carolina State University, ZettaCore, Inc.
    Inventors: Jonathan S. Lindsey, Robert S. Loewe, Kannan Muthukumaran, Arounaguiry Ambroise
  • Synthesis of Phosphono-Substituted Porphyrin Compounds for Attachment to Metal Oxide Surfaces
    Publication number: 20120322999
    Abstract: A method of making a phosphono-substituted dipyrromethane comprises reacting an aldehyde or acetal having at least one phosphono group substituted thereon with pyrrole to produce a phosphono-substituted dipyrromethane; and wherein the phosphono is selected from the group consisting of dialkyl phosphono, diaryl phosphono, and dialkylaryl phosphono. Additional methods, intermediates and products are also described.
    Type: Application
    Filed: August 29, 2012
    Publication date: December 20, 2012
    Inventors: Jonathan S. Lindsey, Robert S. Loewe, Kannan Muthukumaran, Arounaguiry Ambroise
  • Synthesis of phosphono-substituted porphyrin compounds for attachment to metal oxide surfaces
    Patent number: 8278439
    Abstract: A method of making a phosphono-substituted dipyrromethane comprises reacting an aldehyde or acetal having at least one phosphono group substituted thereon with pyrrole to produce a phosphono-substituted dipyrromethane; and wherein the phosphono is selected from the group consisting of dialkyl phosphono, diaryl phosphono, and dialkylaryl phosphono. Additional methods, intermediates and products are also described.
    Type: Grant
    Filed: November 18, 2011
    Date of Patent: October 2, 2012
    Assignees: North Carolina State University, ZettaCore, Inc.
    Inventors: Jonathan S. Lindsey, Robert S. Loewe, Kannan Muthukumaran, Arounaguiry Ambroise
  • SYNTHESIS OF PHOSPHONO-SUBSTITUTED PORPHYRIN COMPOUNDS FOR ATTACHMENT TO METAL OXIDE SURFACES
    Publication number: 20120065391
    Abstract: A method of making a phosphono-substituted dipyrromethane comprises reacting an aldehyde or acetal having at least one phosphono group substituted thereon with pyrrole to produce a phosphono-substituted dipyrromethane; and wherein the phosphono is selected from the group consisting of dialkyl phosphono, diaryl phosphono, and dialkylaryl phosphono. Additional methods, intermediates and products are also described.
    Type: Application
    Filed: November 18, 2011
    Publication date: March 15, 2012
    Inventors: Jonathan S. Lindsey, Robert S. Loewe, Kannan Muthukumaran, Arounaguiry Ambroise
  • Long wavelength thiol-reactive fluorophores
    Patent number: 8129525
    Abstract: Reactive fluorescent dyes compositions and methods of using same are disclosed. Nile Red nucleus dyes are disclosed having thiol-reactive groups. Nile Red nucleus dyes are disclosed that exhibit a fluorescence emission of at least about 575 nm.
    Type: Grant
    Filed: June 22, 2009
    Date of Patent: March 6, 2012
    Assignee: Becton Dickinson and Company
    Inventors: J. Bruce Pitner, Douglas B. Sherman, Arounaguiry Ambroise, Joseph Thomas
  • Synthesis of phosphono-substituted porphyrin compounds for attachment to metal oxide surfaces
    Patent number: 8080653
    Abstract: A method of making a phosphono-substituted dipyrromethane comprises reacting an aldehyde or acetal having at least one phosphono group substituted thereon with pyrrole to produce a phosphono-substituted dipyrromethane; and wherein the phosphono is selected from the group consisting of dialkyl phosphono, diaryl phosphono, and dialkylaryl phosphono. Additional methods, intermediates and products are also described.
    Type: Grant
    Filed: May 28, 2009
    Date of Patent: December 20, 2011
    Assignees: North Carolina State University, Zettacore, Inc.
    Inventors: Jonathan S. Lindsey, Robert S. Loewe, Kannan Muthukumaran, Arounaguiry Ambroise
  • POLYMERIC BENZYL CARBONATE-DERIVATIVES
    Publication number: 20100048483
    Abstract: The present invention relates to polymeric derivatives, which can be conjugated to an amino-containing drug to improve its in vivo properties. The polymeric derivative can subsequently be released to yield the drug in its native form. Methods of preparing and using these polymeric derivatives and drug conjugates are described.
    Type: Application
    Filed: August 21, 2009
    Publication date: February 25, 2010
    Applicants: BAXTER HEALTHCARE S.A., BAXTER INTERNATIONAL INC.
    Inventors: Guohan Yang, Ton T. Hai, Bennett Melnick, Paul Sanders, Cong Jiang, Catherine Quinn, Jie Li, Arounaguiry Ambroise, Larry R. Brown
  • LONG WAVELENGTH THIOL-REACTIVE FLUOROPHORES
    Publication number: 20100003763
    Abstract: Reactive fluorescent dyes compositions and methods of using same are disclosed. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed having thiol-reactive groups. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed that exhibit a fluorescence emission of at least about 575 nm. Biosensors are disclosed having a binding protein and a squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus.
    Type: Application
    Filed: June 22, 2009
    Publication date: January 7, 2010
    Applicant: Becton, Dickinson and Company
    Inventors: J. Bruce Pitner, Douglas B. Sherman, Arounaguiry Ambroise, K. Joseph Thomas
  • SYNTHESIS OF PHOSPHONO-SUBSTITUTED PORPHYRIN COMPOUNDS FOR ATTACHMENT TO METAL OXIDE SURFACES
    Publication number: 20090234136
    Abstract: A method of making a phosphono-substituted dipyrromethane comprises reacting an aldehyde or acetal having at least one phosphono group substituted thereon with pyrrole to produce a phosphono-substituted dipyrromethane; and wherein the phosphono is selected from the group consisting of dialkyl phosphono, diaryl phosphono, and dialkylaryl phosphono. Additional methods, intermediates and products are also described.
    Type: Application
    Filed: May 28, 2009
    Publication date: September 17, 2009
    Inventors: Jonathan S. Lindsey, Robert S. Loewe, Kannan Muthukumaran, Arounaguiry Ambroise
  • Long wavelength thiol-reactive fluorophores
    Patent number: 7563891
    Abstract: Reactive fluorescent dyes compositions and methods of using same are disclosed. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed having thiol-reactive groups. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed that exhibit a fluorescence emission of at least about 575 nm. Biosensors are disclosed having a binding protein and a squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus.
    Type: Grant
    Filed: May 18, 2005
    Date of Patent: July 21, 2009
    Assignee: Becton, Dickinson & Company
    Inventors: J. Bruce Pitner, Douglas B. Sherman, Arounaguiry Ambroise, Joseph Thomas
  • Synthesis of phosphono-substituted porphyrin compounds for attachment to metal oxide surfaces
    Patent number: 7553977
    Abstract: A method of making a phosphono-substituted dipyrromethane comprises reacting an aldehyde or acetal having at least one phosphono group substituted thereon with pyrrole to produce a phosphono-substituted dipyrromethane; and wherein the phosphono is selected from the group consisting of dialkyl phosphono, diaryl phosphono, and dialkylaryl phosphono. Additional methods, intermediates and products are also described.
    Type: Grant
    Filed: November 9, 2007
    Date of Patent: June 30, 2009
    Assignees: North Carolina State University, ZettaCore, Inc.
    Inventors: Jonathan S. Lindsey, Robert S. Loewe, Kannan Muthukumaran, Arounaguiry Ambroise
  • Synthesis of Phosphono-Substituted Porphyrin Compounds for Attachment to Metal Oxide Surfaces
    Publication number: 20080269501
    Abstract: A method of making a phosphono-substituted dipyrromethane comprises reacting an aldehyde or acetal having at least one phosphono group substituted thereon with pyrrole to produce a phosphono-substituted dipyrromethane; and wherein the phosphono is selected from the group consisting of dialkyl phosphono, diaryl phosphono, and dialkylaryl phosphono. Additional methods, intermediates and products are also described.
    Type: Application
    Filed: November 9, 2007
    Publication date: October 30, 2008
    Applicants: North Carolina State University, ZettaCore, Inc.
    Inventors: Jonathan S. Lindsey, Robert S. Loewe, Kannan Muthukumaran, Arounaguiry Ambroise
  • Synthesis of phosphono-substituted porphyrin compounds for attachment to metal oxide surfaces
    Patent number: 7314941
    Abstract: A method of making a phosphono-substituted dipyrromethane comprises reacting an aldehyde or acetal having at least one phosphono group substituted thereon with pyrrole to produce a phosphono-substituted dipyrromethane; and wherein the phosphono is selected from the group consisting of dialkyl phosphono, diaryl phosphono, and dialkylaryl phosphono. Additional methods, intermediates and products are also described.
    Type: Grant
    Filed: October 27, 2006
    Date of Patent: January 1, 2008
    Assignees: North Carolina State University, ZettaCore, Inc.
    Inventors: Jonathan S. Lindsey, Robert S. Loewe, Kannan Muthukumaran, Arounaguiry Ambroise
  • Synthesis of Phosphono-Substituted Porphyrin Compounds for Attachment to Metal Oxide Surfaces
    Publication number: 20070055060
    Abstract: A method of making a phosphono-substituted dipyrromethane comprises reacting an aldehyde or acetal having at least one phosphono group substituted thereon with pyrrole to produce a phosphono-substituted dipyrromethane; and wherein the phosphono is selected from the group consisting of dialkyl phosphono, diaryl phosphono, and dialkylaryl phosphono. Additional methods, intermediates and products are also described.
    Type: Application
    Filed: October 27, 2006
    Publication date: March 8, 2007
    Inventors: Jonathan Lindsey, Robert Loewe, Kannan Muthukumaran, Arounaguiry Ambroise
  • Long wavelength thiol-reactive fluorophores
    Publication number: 20060280652
    Abstract: Reactive fluorescent dyes compositions and methods of using same are disclosed. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed having thiol-reactive groups. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed that exhibit a fluorescence emission of at least about 575 nm. Biosensors are disclosed having a binding protein and a squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus.
    Type: Application
    Filed: May 18, 2005
    Publication date: December 14, 2006
    Inventors: J. Pitner, Douglas Sherman, Arounaguiry Ambroise, K. Thomas
  • Synthesis of phosphono-substituted porphyrin compounds for attachment to metal oxide surfaces
    Patent number: 7148361
    Abstract: A method of making a phosphono-substituted dipyrromethane comprises reacting an aldehyde or acetal having at least one phosphono group substituted thereon with pyrrole to produce a phosphono-substituted dipyrromethane; and wherein the phosphono is selected from the group consisting of dialkyl phosphono, diaryl phosphono, and dialkylaryl phosphono. Additional methods, intermediates and products are also described.
    Type: Grant
    Filed: October 31, 2003
    Date of Patent: December 12, 2006
    Assignees: North Carolina State University, ZettaCore, Inc.
    Inventors: Jonathan S. Lindsey, Robert S. Loewe, Kannan Muthukumaran, Arounaguiry Ambroise
  • Synthesis of phosphono-substituted porphyrin compounds for attachment to metal oxide surfaces
    Publication number: 20050096465
    Abstract: A method of making a phosphono-substituted dipyrromethane comprises reacting an aldehyde or acetal having at least one phosphono group substituted thereon with pyrrole to produce a phosphono-substituted dipyrromethane; and wherein the phosphono is selected from the group consisting of dialkyl phosphono, diaryl phosphono, and dialkylaryl phosphono. Additional methods, intermediates and products are also described.
    Type: Application
    Filed: October 31, 2003
    Publication date: May 5, 2005
    Inventors: Jonathan Lindsey, Robert Loewe, Kannan Muthukumaran, Arounaguiry Ambroise