Abstract: Provided herein are methods for identifying pairs of protein binding partners, mutations of which may inform the discovery of pharmaceutically useful small molecules. The methods disclosed herein may allow for the adaptation of the native protein degradation system to modulate specific disease targets at the protein level, in particular, for targets that have long been considered undruggable.

Abstract: Provided herein are methods for identifying pairs of protein binding partners, mutations of which may inform the discovery of pharmaceutically useful small molecules. The methods disclosed herein may allow for the adaptation of the native protein degradation system to modulate specific disease targets at the protein level, in particular, for targets that have long been considered undruggable.

Abstract: Provided herein are methods for identifying pairs of protein binding partners, mutations of which may inform the discovery of pharmaceutically useful small molecules. The methods disclosed herein may allow for the adaptation of the native protein degradation system to modulate specific disease targets at the protein level, in particular, for targets that have long been considered undruggable.

Abstract: A system and method for generating three dimensional functional space reservation systems of a vehicle from a conceptual space reservation is disclosed. In one embodiment, a method includes collecting functional, connectivity and geometrical information from design databases associated with a conceptual space reservation of a vehicle upon receiving a request from a client device for three dimensional functional space reservation systems. The method also includes creating a mathematical model in a binary form using the functional, connectivity and geometrical information. The method further includes applying a set of rules and checks governing a design of the vehicle to the mathematical model, and applying a set of functional attributes to the mathematical model for creating connectivity information in the mathematical model.

Abstract: A system and method for generating three dimensional functional space reservation systems of a vehicle from a conceptual space reservation is disclosed. In one embodiment, a method includes collecting functional, connectivity and geometrical information from design databases associated with a conceptual space reservation of a vehicle upon receiving a request from a client device for three dimensional functional space reservation systems. The method also includes creating a mathematical model in a binary form using the functional, connectivity and geometrical information. The method further includes applying a set of rules and checks governing a design of the vehicle to the mathematical model, and applying a set of functional attributes to the mathematical model for creating connectivity information in the mathematical model.