Abstract: A composition containing rose hip flesh or rose hips including the naturally occurring amount of seeds, or a concentrate is enriched with rose hip seeds for reducing and/or alleviating symptoms of inflammatory diseases. A method of preparing the rose hip seeds involves separating the rose hip seeds from the flesh prior to or after drying. Drying is preferably performed below 50° C. with the rose hip seeds then ground into a powder and mixed with a rose hip composition, a concentrate or an extract containing rose hip shells or Rose hips including their naturally occurring amount of seeds providing a product enriched with Rose hips seeds preferably containing at least 50% up to 85%, (by weight) of rose hip seeds. The composition is useful in the prophylaxis, treatment or alleviation of symptoms related to inflammatory diseases, in particular joint diseases, such as arthritis rheumatoid arthritis and/or osteo arthritis.

Abstract: The present invention provides a method of preparing a glycoside of a mono- or diacylglycerol product from a plant material. The method comprises the steps of: (i) optionally milling the plant material, (ii) extracting the optionally milled plant material with a first aqueous extraction solution obtaining a first liquid phase and a first solid phase, (iii) separating the liquid phase from the solid phase to obtain a glycoside of mono- or diacylglycerol product, (iv) extracting the solid phase from step (iii) with a second extraction solution obtaining a second liquid phase and a second phase, and (v) separating the second liquid phase from the second solid phase to obtain a second and a third glycoside of mono- or diacylglycerol product, wherein the second extraction solution further comprises a cell wall degrading enzyme or a mixture of cell wall degrading enzymes.

Abstract: A composition containing rose hip flesh or rose hips including the naturally occurring amount of seeds, or a concentrate is enriched with rose hip seeds for reducing and/or alleviating symptoms of inflammatory diseases. A method of preparing the rose hip seeds involves separating the rose hip seeds from the flesh prior to or after drying. Drying is preferably performed below 50° C. with the rose hip seeds then ground into a powder and mixed with a rose hip composition, a concentrate or an extract containing rose hip shells or Rose hips including their naturally occurring amount of seeds providing a product enriched with Rose hips seeds preferably containing at least 50% up to 85%, (by weight) of rose hip seeds. The composition is useful in the prophylaxis, treatment or alleviation of symptoms related to inflammatory diseases, in particular joint diseases, such as arthritis rheumatoid arthritis and/or osteo arthritis.

Abstract: The present invention provides a method of preparing a glycoside of a mono- or diacylglycerol product from a plant material. The method comprises the steps of: (i) optionally milling the plant material, (ii) extracting the optionally milled plant material with a first aqueous extraction solution obtaining a first liquid phase and a first solid phase, (iii) separating the liquid phase from the solid phase to obtain a glycoside of mono- or diacylglycerol product, (iv) extracting the solid phase from step (iii) with a second extraction solution obtaining a second liquid phase and a second phase, and (v) separating the second liquid phase from the second solid phase to obtain a second and a third glycoside of mono- or diacylglycerol product, wherein the second extraction solution further comprises a cell wall degrading enzyme or a mixture of cell wall degrading enzymes.

Abstract: A composition and use of a composition comprising a glycoside of a mono- or diacylglycerol compound and an oil rich in n-3 polyunsaturated fatty acids, e.g. fish oil. The composition may also comprise a rose hip concentrate. The composition is used to treat inflammatory diseases, e.g. joint diseases such as osteoarthritis, or joint pain and stiffness. By administering the composition on a daily basis, a significant reduction in joint pain and stiffness of the affected joints is achieved, which allows individuals suffering from especially joint diseases to resume daily activities.

Abstract: The present application discloses thiourea compounds for use in the treatment of infections. The thiourea compounds have formula (I) wherein X1 and X2 each designate one or more substituents; and Z is —(CHR)—, —(CHR)2—, —O—(CHR)2—, —NH—(CHR)2—, or —S—(CHR)2—; including salts thereof.

Abstract: The present invention provides a method of preparing a glycoside of a mono- or diacylglycerol product from a plant material. The method comprises the steps of: (i) optionally milling the plant material, (ii) extracting the optionally milled plant material with a first aqueous extraction solution obtaining a first liquid phase and a first solid phase, (iii) separating the liquid phase from the solid phase to obtain a glycoside of mono- or diacylglycerol product, (iv) extracting the solid phase from step (iii) with a second extraction solution obtaining a second liquid phase and a second phase, and (v) separating the second liquid phase from the second solid phase to obtain a second and a third glycoside of mono- or diacylglycerol product, wherein the second extraction solution further comprises a cell wall degrading enzyme or a mixture of cell wall degrading enzymes.

Abstract: Glycosides of diacylglycerol, e.g. 3-?-D-galactopyranosyloxy-2-(octadeca-9Z,12Z,15Z-trienoyloxy)propanyl octadeca-9Z,12Z,15Z-trienoate (GOPO), which was isolated from extracts of rose-hips by activity guided fractionation, can be used as an oral anti-inflammatory agent for the treatment of inflammatory diseases such as arthritis and osteoarthrosis.

Abstract: Glycosides of diacylglycerol, e.g. 3-?-D-galactopyranosyloxy-2-(octadeca-9Z,12Z,15Z-trienoyloxy)propanyl octadeca-9Z,12Z,15Z-trienoate (GOPO), which was isolated from extracts of rose-hips by activity guided fractionation, can be used as an oral anti-inflammatory agent for the treatment of inflammatory diseases such as arthritis and osteoarthrosis.

Abstract: The invention is drawn to novel bis-aromatic a,&bgr;-unsaturated ketones. The compounds are useful in the treatment and prophylaxis of diseases caused by parasites or bacteria.

Abstract: Glycosides of diacylglycerol, e.g. 3-&bgr;-D-galactopyranosyloxy-2-(octadeca-9Z,12Z,15Z-trienoyloxy)propanyl octadeca-9Z,12Z,15Z-trienoate (GOPO), which was isolated from extracts of rose-hips by activity guided fractionation, can be used as an oral anti-inflammatory agent for the treatment of inflammatory diseases such as arthritis and osteoarthrosis.

Abstract: The invention relates to the use of 1,3-bis-aromatic-prop-2-en-1-ones (chalcones), 1,3-bis-aromatic-propan-1-ones (dihydrochalcones), and 1,3-bis-aromatic-prop-2-yn-1-ones for the preparation of pharmaceutical compositions for the treatment or prophylaxis of a number of serious diseases including i) conditions relating to harmful effects of inflammatory cytokines, ii) conditions involving infection by Helicobacter species, iii) conditions involving infection by viruses, iv) neoplastic disorders, and v) conditions caused by microorganisms or parasites. The invention also relates to novel chalcones and dihydrochalcones (especially alkoxy substituted variants) having advantageous substitution patterns with respect to their effect as drug substances, and to methods of preparing them, as well as to pharmaceutical compositions comprising the novel chalcones.

Abstract: A formulation having a rose hip concentrate is used to treat and/or alleviate the symptoms associated with inflammation including arthritis or to prevent development of arthritis. The rose hip concentrate has a high vitamin content relative to conventionally dried material, and is shown, in vitro, to inhibit the chemotaxis and oxidative burst response of human peripheral blood inflammatory cells, as well as the chemotaxis of monocytes. The formulation, in vivo, was found to inhibit chemotaxis of human peripheral blood inflammatory cells and to reduce the level of C-reactive protein, to alleviate pain and reduce inflammation in patients with arthritis.

Abstract: Aromatic compounds, or prodrugs thereof, which contain an alkylating site and which are capable of alkylating the thiol group in N-acetyl-L-cysteine, in particular bis-aromatic .alpha.,.beta.-unsaturated ketones, are used for the preparation of pharmaceutical compositions or medicated feed, food or drinking water for the treatment or prophylaxis of diseases caused by microorganisms or parasites, in particular protozoa such as Leishmannia, Trypanosoma, Toxoplasma, Plasmodium, Pneumocystis, Babesia and Theileria, intestinal protozoa such as Trichormionas and Ciardia; Coccidia such as Eimeria, Isospora, Cryptosporidium; Cappilaria, Microsporidium, Sarcocystis. Trichlodina, Trichoditella, Dacihylogurus, Pseudodacthylogurus, Acantocephalus, Ichthylophtherius, Botrecephalus; and intracellular bacteria, in particular Mycobacterium, Legionella species, Listeria and Salmonella. Preferred compounds have the formula (II): X.sub.m --Ph--C(O)--CH.dbd.CH--Ph--Y.sub.