Patents by Inventor Arsenio A. Pessolano

Arsenio A. Pessolano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immunosuppressive fluorinated cyclosporin analogs
    Patent number: 5227467
    Abstract: New immunosuppressive cyclosporin analogs are disclosed having one or more fluorinated amino acids. These analogs may also have a "C-9 amino acid" wherein the double bond is replaced by a heteroatom such as sulfur or oxygen.
    Type: Grant
    Filed: April 29, 1991
    Date of Patent: July 13, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Philippe L. Durette, Arsenio A. Pessolano, Janos Kollonitsch
  • Derivatives of 3-hydroxyazabenzo(beta)thiophene useful as 5-lipoxygenase inhibitors
    Patent number: 5006532
    Abstract: 3-Hydroxyazabenzo[b]thiophene derivatives having optionally 2-aryl, 2-aralkyl, 2-alkyl or 2-alkenyl substituents were prepared by, among other methods, ring closure of an appropriately substituted benzylthio-alkoxycarbonyl-pyridine. These compounds are found to be useful in the treatment of pain, fever, inflammation, arthritic conditions, asthma, allergic disorders, skin diseases such as psoriasis and atopic eczema, cardiovascular disorders, inflammatory diseases and other leukotriene mediated diseases.
    Type: Grant
    Filed: December 8, 1989
    Date of Patent: April 9, 1991
    Assignee: Merck & Co. Inc., Inc.
    Inventors: Robert K. Baker, Arsenio A. Pessolano, Kathleen M. Rupprecht, Philippe L. Durette
  • Novel 6-position cyclosporin analogs as non-immunosuppressive antagonists of cyclosporin binding to cyclophilin
    Patent number: 4914188
    Abstract: Novel cyclosporin analogs containing a MeAla or MeAbu residue at the 6-position of the cyclic undecapeptide have been synthesized and found unexpectedly to exhibit antagonistic activity toward cyclosporin A binding to its cytosolic protein receptor, cyclophilin, without being immunosuppressive.
    Type: Grant
    Filed: November 16, 1987
    Date of Patent: April 3, 1990
    Assignee: Merck & Co., Inc.
    Inventors: Francis J. Dumont, Philippe L. Durette, Arsenio A. Pessolano, Joshua S. Boger, Nolan H. Sigal
  • Derivatives of 3-hydroxyazabenzo[b]thiophene useful as 5-lipoxygenase inhibitors
    Patent number: 4904672
    Abstract: 3-Hydroxyazabenzo[b]thiophene derivatives having optionally 2-aryl, 2-aralkyl, 2-alkyl or 2-alkenyl substituents were prepared by, among other methods, ring closure of an appropriately substituted benzylthioalkoxycarbonyl-pyridine. These compounds are found to be useful in the treatment of pain, fever, inflammation, arthritic conditions, asthma, allergic disorders, skin diseases such as psoriasis and atopic eczema, cardiovascular disorders, inflammatory disease and other leukotriene mediated diseases.
    Type: Grant
    Filed: April 28, 1988
    Date of Patent: February 27, 1990
    Assignee: Merck & Co., Inc.
    Inventors: Robert K. Baker, Kathleen M. Rupprecht, Arsenio A. Pessolano, Philippe L. Durette
  • Derivatives of 3-hydroxyazabenzo(B)thiophene useful as 5-lipoxygenase inhibitors
    Patent number: 4767766
    Abstract: 3-Hydroxyazabenzo[b]thiophene derivatives having optionally 2-aryl, 2-aralkyl, 2-alkyl or 2-alkenyl substituents were prepared by, among other methods, ring closure of an appropriately substituted benzylthio-alkoxycarbonyl-pyridine. These compounds are found to be useful in the treatment of pain, fever, inflammation, arthritic conditions, asthma, allergic disorders, skin diseases such as psoriasis and atopic eczema, cardiovascular disorders, inflammatory diseases and other leukotriene mediated diseases.
    Type: Grant
    Filed: January 30, 1987
    Date of Patent: August 30, 1988
    Assignee: Merck & Co., Inc.
    Inventors: Robert K. Baker, Kathleen M. Rupprecht, Arsenio A. Pessolano, Philippe L. Durette
  • 2-benzyl-4-(4-pyridyl)thiazoles and derivatives thereof as immunoregulants and compositions
    Patent number: 4725606
    Abstract: 2-Benzyl-4-(4-pyridyl)thiazoles and derivatives thereof have been made from converting a benzyl cyanide to the corresponding thioamide followed by condensation with a 4-bromoacetylpyridine. The thiazole derivatives are found to be effective immunoregulants.
    Type: Grant
    Filed: August 21, 1986
    Date of Patent: February 16, 1988
    Assignee: Merck & Co., Inc.
    Inventors: David A. Boulton, Vernon L. Moore, Ihor E. Kopka, Arsenio A. Pessolano
  • Morpholino pyridyl thiazole compound
    Patent number: 4697012
    Abstract: 2-Benzyl-4-(4-pyridyl)thiazoles and derivatives thereof have been made from converting a benzyl cyanide to the corresponding thioamide followed by condensation with a 4-bromoacetylpyridine. The thiazole derivatives are found to be effective immunoregulants.
    Type: Grant
    Filed: July 25, 1984
    Date of Patent: September 29, 1987
    Assignee: Merck & Co., Inc.
    Inventors: David A. Boulton, Ihor E. Kopka, Vernon L. Moore, Arsenio A. Pessolano
  • Imidazo pyridine-2-ones and pharmaceutical compositions and methods of treatment utilizing same
    Patent number: 4144341
    Abstract: 1,3-Dihydroimidazo[4,5-b]pyridin-2-ones and corresponding thiones have utility as analgesic, antipyretic and antiinflammatory agents. They are generally prepared by treatment of a 2,3-diaminopyridine with phosgene or thiosphosgene followed by further substitution if desired.
    Type: Grant
    Filed: November 22, 1977
    Date of Patent: March 13, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Robert L. Clark, Arsenio A. Pessolano, Tsung-Ying Shen
  • Anti-inflammatory oxazolo [5,4-b]pyridines
    Patent number: 4131677
    Abstract: The various isomers of oxazolo- and thiazolopyridines having utility as antiinflammatory, antipyretic and analgesic agents are prepared by condensation of an appropriate amino-hydroxypyridine or amino-mercaptopyridine with a carboxylic acid, halide or anhydride.
    Type: Grant
    Filed: April 27, 1977
    Date of Patent: December 26, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Tsung-Ying Shen, Robert L. Clark, Arsenio A. Pessolano, Bruce E. Witzel, Thomas J. Lanza
  • Anti-inflammatory oxazole[4,5-b]pyridines
    Patent number: 4038396
    Abstract: The various isomers of oxazolo- and thiazolopyridines having utility as antiinflammatory, antipyretic and analgesic agents are prepared by condensation of an appropriate amino-hydroxypyridine or amino-mercaptopyridine with a carboxylic acid, halide or anhydride.
    Type: Grant
    Filed: May 2, 1975
    Date of Patent: July 26, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Tsung-Ying Shen, Robert L. Clark, Arsenio A. Pessolano, Bruce E. Witzel, Thomas J. Lanza
  • 3-Phenyl,3H 1,2,3 triazolo[4,5-b]pyridines
    Patent number: 4000286
    Abstract: 3H-1,2,3-Triazolo[4,5-b]pyridines substituted in the 3-position have utility as analgesic, anti-inflammatory and anti-pyretic agents. They are prepared by diazotization of a 3-amino-2-(substitute) aminopyridine.
    Type: Grant
    Filed: October 3, 1975
    Date of Patent: December 28, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Robert L. Clark, Arsenio A. Pessolano, Tsung-Ying Shen