Abstract: The present technology includes devices, systems, and method for managing a patient's urine output. In some embodiments, an exemplary method includes receiving an estimated amount of excess fluid for the patient; obtaining a urine output rate of the patient; obtaining a diuretic dosage rate of the patient; obtaining (i) a first input corresponding to a percentage of an actual amount of net fluid loss relative to the estimated amount of excess fluid, and/or (ii) a second input corresponding to an estimated amount of fluid remaining; and based on the first input and/or the second input, providing an output associated with adjusting the fluid therapy. Providing the output can include providing an indication with instructions for increasing the patient's urine output by administering an additional diuretic and/or increasing infusion of hydration fluid to the patient.