Abstract: Derivatives of quinoline and naphthyridine, methods of making such compounds, and methods of using such compounds for the treatment or prophylaxis of HIV infection and certain cancers.

Abstract: Provided is compound of formula (I): where: X and Y may be identical or different and represent O, NH, or S; R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 may be identical or different and represent H, halogen, CN, NO2, (C1-4)alkyl, (C1-4)haloalkyl, (C2-4)alkenyl, OH, O(C1-4)alkyl, O(C1-4)haloalkyl, N(RA)RB, C(O)N(RA)RB, C(O)RA, CO2RA, CHO, C2-4alkenyl substituted with CN, C2-4alkenyl substituted with COOH, C2-4alkenyl substituted with CHO, or C2-4alkenyl substituted with OH; RA and RB may be identical or different and represent H, (C1-4)alkyl, (C1-4)haloalkyl, or (C2-4)alkenyl; A1, A2, A3, and A4 may be identical or different and represent CH or N with the proviso that A1 and A2 cannot be N and that R5 and R10 are absent when A3 and A4 are N; or a pharmaceutically acceptable salt thereof, stereoisomer thereof, or mixture comprising stereoisomers thereof.