Patents by Inventor Arthur A. Gertzman

Arthur A. Gertzman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9138509
    Abstract: The invention is directed toward an improved formable bone composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing compound of demineralized lyophilized allograft bone particles ranging from about 100 to 850 microns. The bone particles are mixed in an excipient carrier combination containing carboxymethylcellulose, sodium hyaluronate, and a sodium phosphate saline buffer, the carboxymethylcellulose component of the carrier ranging from about 5.0 to about 11.0% of the composition and the sodium hyaluronate component of the carrier ranging from about 0.3 to about 0.7% of the composition, the composition having a pH between 6.5-7.5.
    Type: Grant
    Filed: September 14, 2007
    Date of Patent: September 22, 2015
    Assignee: MUSCULOSKELETAL TRANSPLANT FOUNDATION
    Inventors: Moon Hae Sunwoo, Victor A. Lizano, Arthur A. Gertzman
  • Patent number: 8883210
    Abstract: The disclosure provides implants containing a plurality of particles containing at least one population of viable tissuegenic cells adherent to and resident in the growth-conductive matrix or at least viable population of tissuegenic cells caused to be in contact with the growth-conductive matrix; methods to fabricate implants; methods of fabricating the implants; and use of the implants in tissue repair.
    Type: Grant
    Filed: May 16, 2011
    Date of Patent: November 11, 2014
    Assignee: Musculoskeletal Transplant Foundation
    Inventors: Katherine Gomes Truncale, Arthur A. Gertzman, Yen-Chen Huang, Eric Semler, Evangelia Chnari, Anouska Dasgupta, Judith Yannariello-Brown, Terri Riley
  • Patent number: 8834928
    Abstract: The disclosure provides implants containing a plurality of particles containing at least one population of viable tissuegenic cells adherent to and resident in the growth-conductive matrix or at least viable population of tissuegenic cells caused to be in contact with the growth-conductive matrix; methods to fabricate implants; methods of fabricating the implants; and use of the implants in tissue repair.
    Type: Grant
    Filed: July 23, 2013
    Date of Patent: September 16, 2014
    Assignee: Musculoskeletal Transplant Foundation
    Inventors: Katherine Gomes Truncale, Arthur A. Gertzman, Yen-Chen Huang, Eric Semler, Evangelia Chnari, Anouska Dasgupta, Judith Yannariello-Brown, Terri Riley
  • Publication number: 20140058527
    Abstract: The invention is directed toward a sterile cartilage defect implant material comprising milled lyophilized allograft cartilage pieces ranging from 0.01 mm to 1.0 mm in size in a bioabsorbable carrier taken from a group consisting of sodium hyaluronate, hyaluronic acid and its derivatives, gelatin, collagen, chitosan, alginate, buffered PBS, Dextran or mixed polymers with allograft chondrocytes added in an amount ranging from 2.5×105 to 2.5×107.
    Type: Application
    Filed: October 31, 2013
    Publication date: February 27, 2014
    Applicant: Musculoskeletal Transplant Foundation
    Inventors: Katherine Gomes Truncale, Arthur A. Gertzman, Moon Hae Sunwoo, William W. Tomford
  • Patent number: 8562613
    Abstract: The present invention is a kit and a method of using a kit for treating bone including a fill material mixture made of osteoconductive material, osteoinductive material and a lubricating carrier, a porous container to receive the fill material mixture and a tool that flowably introduces the fill material mixture into the porous container.
    Type: Grant
    Filed: April 5, 2010
    Date of Patent: October 22, 2013
    Assignees: Spineology Inc., Musculoskeletal Transplant Foundation
    Inventors: James W. Ahern, Arthur Gertzman, Karen Roche, Moon Hae Sunwoo, Steven Wolfe, John E. Kuslich
  • Patent number: 8292968
    Abstract: A construct for repairing articular cartilage defects includes a cap member and a base member. The cap member has an upper section and a stem depending from a central region thereof. The upper section includes a peripheral region. The stem includes a cavity. The base member has first and second ends, the first end including an annular recess dimensioned such that the stem is receivable therein. The first end also includes an annular edge positioned laterally outwardly from the annular recess, for abutting and supporting the peripheral region of the upper section when the stem is received in the annular recess. The base member further includes an island which is surrounded by the annular recess and receivable in the cavity of the stem, such that the island is abuttable with and may thereby support the central region of the upper section when the stem is received in the annular recess.
    Type: Grant
    Filed: February 1, 2011
    Date of Patent: October 23, 2012
    Assignee: Musculoskeletal Transplant Foundation
    Inventors: Katherine G. Truncale, Eric J. Semler, Arthur A. Gertzman, Moon Hae Sunwoo, William W. Tomford, Roman Shikhanovich
  • Publication number: 20120251609
    Abstract: A demineralized cancellous bone matrix comprising a cancellous bone matrix that has been demineralized is described herein. The demineralized cancellous bone matrix is rigid and has certain dimensions, including a certain length. Implants comprising at least one demineralized cancellous bone matrix are also described. Also disclosed are methods for treating bone having a void or defect in a patient using at least one demineralized cancellous bone matrix. In addition, methods of making a demineralized cancellous bone matrix are disclosed.
    Type: Application
    Filed: March 29, 2011
    Publication date: October 4, 2012
    Inventors: Yen-Chen Huang, Moon Hae Sunwoo, Arthur A. Gertzman
  • Publication number: 20120205274
    Abstract: The invention is directed toward an osteoimplant for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing composition of demineralized allograft bone material mixed with an aqueous phosphate buffered gelatin which when lyophilized to remove water from the composition crosslinks the gelatin to form a solid structure and when rehydrated is flexible
    Type: Application
    Filed: April 26, 2012
    Publication date: August 16, 2012
    Inventors: Moon Hae Sunwoo, Arthur A. Gertzman, Barbara L. Merboth
  • Patent number: 8221500
    Abstract: The invention is directed toward a cartilage repair assembly comprising a shaped allograft structure of subchondral bone with an integral overlying cartilage cap which is treated to remove cellular debris and proteoglycans and milled allograft cartilage in a bioabsorbable carrier. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that either the shaped bone or the cartilage cap engage the side wall of the drilled bore in an interference fit and is in contact with a milled cartilage and biocompatible carrier mixture allowing cell transfer throughout the defect area. A method for inserting the shaped allograft structure into a cartilage defect area is also disclosed.
    Type: Grant
    Filed: July 24, 2008
    Date of Patent: July 17, 2012
    Assignee: Musculoskeletal Transplant Foundation
    Inventors: Katherine Gomes Truncale, Arthur A. Gertzman, Moon Hae Sunwoo, William W Tomford
  • Publication number: 20110196508
    Abstract: The invention is directed toward a sterile cartilage defect implant material comprising milled lyophilized allograft cartilage pieces ranging from 0.01 mm to 1.0 mm in size in a bioabsorbable carrier taken from a group consisting of sodium hyaluronate, hyaluronic acid and its derivatives, gelatin, collagen, chitosan, alginate, buffered PBS, Dextran or mixed polymers with allograft chondrocytes added in an amount ranging from 2.5×105 to 2.5×107.
    Type: Application
    Filed: February 11, 2011
    Publication date: August 11, 2011
    Inventors: Katherine Gomes Truncale, Arthur A. Gertzman, Moon Hae Sunwoo, William W. Tomford
  • Publication number: 20110166669
    Abstract: Constructs that are at least partially constructed of allograft cancellous bone are disclosed, along with cartilage particles that may be used with the constructs for repairing articular cartilage defects. A multi-piece construct includes a base member, a cap member and at least one pin that secures the cap member to the base member. The base member may be constructed of mineralized cancellous bone, and is used to replace the subchondral bone removed when a surgeon cuts a bore in the area of an adjacent cartilage defect. The base member includes a blind bore and first and second through-going transverse bores in opposite sides of a wall of the base member. The cap member includes an upper section that has a thickness that is similar to that of a patient's surrounding articular cartilage layer and a stem depending from the upper section that is dimensioned to be received in and by the blind bore of the base member.
    Type: Application
    Filed: February 1, 2011
    Publication date: July 7, 2011
    Inventors: Katherine G. Truncale, Eric J. Semler, Arthur A. Gertzman, Moon Hae Sunwoo, William W. Tomford, Roman Shikhanovich
  • Publication number: 20110070284
    Abstract: Described herein are methods and compositions related to biologic matrices comprising at least one anti-infective. In certain embodiments, the invention relates to a biologic matrix comprising a slowed release anti-infective agent. In a particular embodiment, the invention relates to an acellular dermal matrix comprising a slowed release antiinfective agent, wherein the anti-infective agent is triclosan. In further embodiments, the the biologic matrix is suitable for use in surgical procedures, such as, for example, for the replacement of damaged or inadequate integumental tissue or for the repair, reinforcement or supplemental support of soft tissue defects.
    Type: Application
    Filed: February 23, 2009
    Publication date: March 24, 2011
    Applicant: MUSCULOSKELETAL TRANSPLANT FOUNDATION
    Inventors: Carl Alexander Depaula, Arthur A. Gertzman, Moonhae Sunwoo
  • Publication number: 20110070271
    Abstract: Constructs that are at least partially constructed of allograft cancellous bone are disclosed, along with cartilage particles that may be used with the constructs for repairing articular cartilage defects. A multi-piece construct includes a base member, a cap member and at least one pin that secures the cap member to the base member. The base member may be constructed of mineralized cancellous bone, and is used to replace the subchondral bone removed when a surgeon cuts a bore in the area of an adjacent cartilage defect. The base member includes a blind bore and first and second through-going transverse bores in opposite sides of a wall of the base member. The cap member includes an upper section that has a thickness that is similar to that of a patient's surrounding articular cartilage layer and a stem depending from the upper section that is dimensioned to be received in and by the blind bore of the base member.
    Type: Application
    Filed: September 21, 2010
    Publication date: March 24, 2011
    Inventors: Katherine G. Truncale, Moon Hae Sunwoo, Arthur A. Gertzman, William W. Tomford
  • Publication number: 20110059178
    Abstract: A meniscus repair composition for application to a meniscus defect site to promote growth of new tissue at the meniscus defect site is provided. The composition comprises: from about 10 to about 50 percent by weight of allograft meniscus particles having an average particle size of from about 10 ?m to about 500 ?m; a carrier selected from the group consisting of sodium hyaluronate, gelatin, collagen, polyethylene glycol, glycerin, carboxymethylcellulose, dextrose, blood derivatives, aqueous solutions thereof, and mixtures thereof; and a curing agent. The curing agent may be the carrier where the carrier is cross-linkable. When introduced to a defect site in a meniscus and cured, the composition will not flow away from the defect site, and the composition is non-adhering to the defect site after it is cured.
    Type: Application
    Filed: September 3, 2010
    Publication date: March 10, 2011
    Applicant: MUSCULOSKELETAL TRANSPLANT FOUNDATION INC.
    Inventors: Eric J. Semler, Arthur A. Gertzman, Yen-Chen Huang, Judith Yannariello-Brown, Katherine Gomes Truncale
  • Publication number: 20110060412
    Abstract: A meniscus repair composition for application to a meniscus injury to promote growth of new tissue at the meniscus injury site is provided. The composition comprises: from about 10 to about 50 percent by weight of allograft meniscus particles having an average particle size of from about 10 ?m to about 500 ?m; and a carrier comprising a solid fibrin web matrix. When introduced to a defect site in a meniscus, the composition is non-adhering to the defect site. A method for repairing a meniscus injury comprises administering a meniscus repair composition to the injury site.
    Type: Application
    Filed: September 3, 2010
    Publication date: March 10, 2011
    Applicant: MUSCULOSKELETAL TRANSPLANT FOUNDATION INC.
    Inventors: Eric J. Semler, Arthur A. Gertzman, Yen-Chen Huang, Judith Yannariello-Brown, Katherine Gomes Truncale
  • Patent number: 7901457
    Abstract: The invention is directed toward a cartilage repair assembly comprising a shaped allograft structure of subchondral bone with an integral overlying cartilage cap which is treated to remove cellular debris and proteoglycans and milled allograft cartilage in a bioabsorbable carrier. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that either the shaped bone or the cartilage cap engage the side wall of the drilled bore in an interference fit and is in contact with a milled cartilage and biocompatible carrier mixture allowing cell transfer throughout the defect area. A method for inserting the shaped allograft structure into a cartilage defect area is also disclosed.
    Type: Grant
    Filed: May 16, 2003
    Date of Patent: March 8, 2011
    Assignee: Musculoskeletal Transplant Foundation
    Inventors: Katherine Gomes Truncale, Arthur A. Gertzman, Moon Hae Sunwoo, William W. Tomford
  • Patent number: 7879103
    Abstract: A sterile implant for treatment of a spinal disc defect comprising an allograft cortical bone demineralized to a Type I collagen having a specific shape which is treated to eliminate osteoinductivity. The implant is lyophilized and compressed into smaller first shape which 20 to 80% from its original shape in at least one dimension and hardened. The implant expanding when hydrated into a second shape having the shape memory of the first shape and expanded in dimensional size from the first compressed shape.
    Type: Grant
    Filed: April 17, 2006
    Date of Patent: February 1, 2011
    Assignee: Musculoskeletal Transplant Foundation
    Inventors: Arthur A. Gertzman, Barbara L. Merboth, Michael Schuler, Anton J. Steiner, Eric J. Semler, Judith I. Yannariello-Brown
  • Publication number: 20100296969
    Abstract: The present invention is a process for preparing skin removed from a human donor, removal of cellular components and sterilizing the decellularized skin. The process comprises the following steps: (a) decellularizing the skin including soaking the skin in a detergent and rinsing same with sterile water; (b) sterilizing the skin under vacuum with one or more of ozone, vapor H2O2, plasma H2O2, ethylene oxide gas, or sodium hydroxide for a time period to achieve a concentration to achieve sterilization of the skin; and (c) processing the skin by cutting the skin to a designated size.
    Type: Application
    Filed: June 12, 2008
    Publication date: November 25, 2010
    Applicant: Musculoskeletal Transplant Foundation
    Inventors: Manh-Dan Ngo, Jeffrey Stuart Cartmell, Arthur Gertzman
  • Patent number: RE42208
    Abstract: The invention is directed toward a sterile cartilage defect implant material comprising milled lyophilized allograft cartilage pieces ranging from 0.01 mm to 1.0 mm in size in a bioabsorbable carrier taken from a group consisting of sodium hyaluronate, hyaluronic acid and its derivatives, gelatin, collagen, chitosan, alginate, buffered PBS, Dextran or polymers with allogenic chondrocytes or bone marrow cells in an amount exceeding the natural occurrence of same in hyaline cartilage and adding a cell growth additive.
    Type: Grant
    Filed: June 26, 2008
    Date of Patent: March 8, 2011
    Assignee: Musculoskeletal Transplant Foundation
    Inventors: Katherine Gomes Truncale, Arthur A. Gertzman, Moon Hae Sunwoo, William W. Tomford
  • Patent number: RE43258
    Abstract: The invention is directed toward a sterile cartilage defect implant material comprising milled lyophilized allograft cartilage pieces ranging from 0.01 mm to 1.0 mm in size in a bioabsorbable carrier taken from a group consisting of sodium hyaluronate, hyaluronic acid and its derivatives, gelatin, collagen, chitosan, alginate, buffered PBS, Dextran or polymers with allogenic chondrocytes or bone marrow cells in an amount exceeding the natural occurrence of same in hyaline cartilage and adding a cell growth additive.
    Type: Grant
    Filed: December 13, 2010
    Date of Patent: March 20, 2012
    Assignee: Musculoskeletal Transplant Foundation
    Inventors: Katherine G. Truncale, Moon Hae Sunwoo, Arthur A. Gertzman, William W. Tomford