Abstract: A process for preparing certain benzo- and thieno-fused heterocyclic compounds having H.sub.2 -receptor antagonist and antisecretory activity, which comprises the amide reduction of N-substituted carbamoyl-containing benzo- or thieno-fused heterocyclic intermediates; and said N-substituted carbamoyl-containing benzo- or thieno-fused heterocyclic intermediates.

Abstract: Compounds of the formula: ##STR1## wherein A is ##STR2## R is mono- or dihalo, amino, nitro, cyano, hydroxy, trifluoromethyl, mercapto, lower alkyl, lower alkoxy, alkanoyl, lower cycloalkyl, carboxy, alkoxycarbonyl, mono- or di-lower alkyl substituted amino, alkanoylamino, lower alkyl thio, loweralkyl-sulfonyl, sulfamoyl, lower alkyl substituted sulfamoyl, phenyl or phenyl substituted with halo, lower alkyl, lower alkoxy, trifluoromethyl, hydroxy, amino, cyano or nitro;X and Y are each, independently, hydrogen or ##STR3## wherein R.sup.1 is hydrogen or lower alkyl;R.sup.2 is hydrogen or lower alkyl; orR.sup.1 and R.sup.2 taken together form a heterocyclic moiety selected from 1-pyrrolidinyl, 1-piperidinyl, 1-hexahydroazepinyl, 1-octahydroazocinyl, 3-thiazolidinyl, 4-morpholinyl or 4-thiomorpholinyl, with the proviso that one of X and Y is always hydrogen;n is 1-4;and the pharmacologically acceptable salts thereof, which are intermediates in preparing H.sub.

Abstract: Compounds of the formula: ##STR1## wherein R.sup.1 is hydrogen, cyano or cyano(lower)alkyl;R.sup.2 is hydrogen, cyano, carboxy, carbamoyl, guanyl, (lower)alkoxyimino, hydrazinocarbonyl, (lower)alkylaminoimino, ##STR2## with the proviso that one but never both of R.sup.1 and R.sup.2 is hydrogen; and the pharmacologically acceptable salts thereof exhibit H.sub.2 -receptor antagonist and gastric secretion inhibition activity.

Abstract: 4-Amino-3-carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives are anti-secretory agents for use in the treatment of peptic ulcer disease.4-Cl, Br or I naphthyridine derivatives are disclosed as intermediates.

Abstract: 4-Amino-3-carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives are anti-secretory agents for use in the treatment of peptic ulcer disease.

Abstract: 7,8-Dihydro-2,5,8-trisubstituted-7-oxo-pyrido[2,3-d]pyrimidine-6-carboxylic acid amide derivatives are gastric anti-secretory agents for treatment of peptic ulcer disease and generally anti-allergic agents useful in the treatment of atopic immediate hypersensitivity reactions.

Abstract: 1,2-Dihydro-4-amino-2-oxo-3-quinolinecarboxylic acids, esters and amide derivatives are disclosed as anti-secretory agents useful in the treatment of peptic ulcer disease.

Abstract: 1,2-Dihydro-4-hydroxy-2-imino-N-substituted-3-quinolinecarboxamide derivatives are disclosed as diuretic agents.

Abstract: The disclosed 2H-pyrimido[4,5-d][1,3]oxazine-2,4(1H)-dione derivatives are intermediates useful in the production of 7,8-dihydro-2,5,8-trisubstituted-7-oxo-pyrido[2,3-d]pyrimidine-6-carboxyli c acid derivatives which are gastric anti-secretory agents and anti-allergic agents.

Abstract: The 5-amino-2,8-dialkyl-7,8-dihydro-7-oxo-pyrido[2,3-d]-pyrimidine-6-carboxyli c acid derivatives of the invention are anti-secretory agents.

Abstract: 2-Alkylsulfonyl-7,8-dihydro-5-hydroxy-7-oxo-pyrido[2,3-d]pyrimidine-6-carbo xylic acid derivatives are intermediates useful in the production of 7,8-dihydro-2-amino or alkoxy-7-oxo-pyrido[2,3-d]pyrimidine-6-carboxylic acid derivatives which are gastric anti-secretory agents for treatment of peptic ulcer disease and generally anti-allergic agents useful in the treatment of atopic immediate hypersensitivity reactions.

Abstract: 7-Chloro-7,8-dihydro-7-oxo-pyrido[2,3]-d]pyrimidine-6-carboxylic acid derivatives are intermediates useful for the production of 7,8-dihydro-2,5,8-trisubstituted-7-oxo-pyrido[2,3-d]-pyrimidine-6-carboxyl ic acid derivatives which in turn are gastric anti-secretory agents for treatment of peptic ulcer disease and generally anti-allergic agents useful in the treatment of atopic immediate hypersensitivity reactions.

Abstract: 7,8-Dihydro-2,5,8-trisubstituted-7-oxo-pyrido[2,3-d]pyrimidine-6-carboxylic acid derivatives are gastric anti-secretory agents for treatment of peptic ulcer disease and generally anti-allergic agents useful in the treatment of atopic immediate hypersensitivity reactions.

Abstract: Substituted 4-oxy-3-carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives as gastric antisecretory agents for use in the treatment of peptic ulcer disease.

Abstract: Disclosed herein are 3-[(chlorophenylsulfonyl)methyl]-1,2,4-oxadiazole-5-carboxylic acid derivatives and 3-[(chlorophenylsulfonyl)ethyl]-1,2,4-oxadiazole-5-carboxylic acid derivatives exhibiting antihypertensive or antiviral activity and having the following formula: ##STR1## wherein: X = 1 or 2; andZ is --OR, --OH, --OK, --ONa, --NHOH, --NHNH.sub.2, --NHNHCOCO.sub.2 R, or --NHNHSO.sub.2 R; andR is --CH.sub.3, --CH.sub.2 CH.sub.3, --CH.sub.2 CH.sub.2 CH.sub.3 or --CH(CH.sub.3).sub.2.

Abstract: The disclosure is directed to 1,6-bis-(substituted oxy)-xanthen-9-ones which have the formula ##SPC1##Where R.sub.1 is morpholino(lower)alkyl, di(lower)alkylamino(lower)-alkyl, or pyrrolidinyl(lower)alkyl; and R.sub.2 is lower alkylamino (lower)alkyl or hydrogen. The compounds are active as immunoregulators or as intermediates in the preparation of immunoregulators. The intermediates also have trichomonacidal activity.

Abstract: The compounds ##SPC1##In which the symbol A represents a carbon or nitrogen atom, X represents --Cl, lower alkoxy or the substituted amino group ##SPC2##Y represents --Cl, lower alkoxy, ##SPC3##With the proviso that when Y is --Cl, X and Z are other than --Cl, and Z represents --H, --Cl, --OCH.sub.2 CO.sub.2 R, --SCH.sub.2 C.tbd.CH, ##SPC4##wherein R and R.sup.2 are --H or lower alkyl,R.sup.3 is --H, --Cl or lower alkyl, and n represents one of the integers 0 and 1, exhibit anti-lipemic activity and/or central nervous system depressant activity in warm-blooded animals.

Abstract: 2-(6-alkyl or phenyl-2-pyrimidinylthio)acetamidoximes, in which the 4-position is substituted with the p-chlorobenzylamino, p-methoxyphenylamino, or 1,3-benzodioxol-5-yl-methylamino group, have antiarrhythmic activity. The compounds are prepared from an appropriately substituted 2-pyrimidinylthio)acetonitrile by reaction with hydroxylamine hydrochloride.

Abstract: (2-Pyrimidinylthio)alkanoic acid, esters, amides and hydrazides as well as various 4- and 6-substituted derivatives thereof as depicted by the structural formula: ##SPC1##In which R and R.sup.2 are independently --H or lower alkyl; R.sup.1 is --H, -halo or lower alkoxy; Z is --OH, OM, lower alkoxy or --(NH).sub.1 --NH.sub.2, wherein p is 0 to 1 and M is an alkali metal, alkaline earth metal or ammonium cation; Y is an aryl, amino or substituted amino radical; and m is an integer from 0 to 2, exhibit anti-lipemic activity in warm-blooded animals.

Abstract: The invention is directed to 4-amino-2-phenyl-6-thiopyrimidine compounds having the formula ##SPC1##Where R.sup.1 -R.sup.3 are as defined in the specification. The compounds have pharmacodynamic activity as central nervous system depressants. That is, they produce a calming effect in the host.