Abstract: The disclosure notably relates to a computer-implemented method for simulating evolution of a tumor associated to an oncogene. The method includes providing a plurality of pieces of data, each corresponding to a given cell of the tumor, and includes a degree of activation of the oncogene in the given cell. The method further includes providing a model configured to take an input piece of data and to output information on proliferation of the respective given cell corresponding to the input piece of data. The information on proliferation depends on the degree of activation of the oncogene. The method further includes running the model on one or more pieces of data of the plurality of pieces of data and updating the plurality of pieces of data based on the result of the running. Such a method improves the simulation of the evolution of a tumor.

Abstract: A computer-implemented method for training a neural network for inferring a gene expression profile.

Abstract: A computer-implemented method for machine-learning a neural network for variant calling with respect to a reference genome. The neural network takes as input one or more sets of data pieces each specifying a respective read aligned relative to a genomic position of the reference genome. The neural network outputs information with respect to presence of a variant at the genomic position. The neural network includes, for each set of data pieces, a respective function configured to take as input and process the set of data pieces. The respective function is symmetric. The machine-learning method improves variant calling with respect to a reference genome.

Abstract: The disclosure notably relates to a computer-implemented method for simulating evolution of a tumor associated to an oncogene. The method includes providing a plurality of pieces of data, each corresponding to a given cell of the tumor, and includes a degree of activation of the oncogene in the given cell. The method further includes providing a model configured to take an input piece of data and to output information on proliferation of the respective given cell corresponding to the input piece of data. The information on proliferation depends on the degree of activation of the oncogene. The method further includes running the model on one or more pieces of data of the plurality of pieces of data and updating the plurality of pieces of data based on the result of the running. Such a method improves the simulation of the evolution of a tumor.

Abstract: A composite tubeshaft comprising a composite substrate defined by a first surface and a second surface; and a metallic substrate having at least two teeth. The teeth of the metallic substrate engage the composite substrate such that at least one tooth is positioned over the first surface and at least one tooth is positioned over the second surface.

Abstract: A composite tubeshaft comprising a composite substrate defined by a first surface and a second surface; and a metallic substrate having at least two teeth. The teeth of the metallic substrate engage the composite substrate such that at least one tooth is positioned over the first surface and at least one tooth is positioned over the second surface.

Abstract: A shaft assembly is provided to reduce breathing mode vibrations and resulting noises. The shaft assembly includes a shaft member having an outer surface and a damping member constructed at least in part from a damping material and including a substantially annular body and generally opposing ends. The opposing ends are biased such that at least a portion of the damping member engages with the shaft member.

Abstract: A vehicle driveline includes a tubular member (62) having an inside surface (64) and an axis, a mounting base (72) coupled to the tubular member (62), and a plurality of resonator members (74) each having a first end (80), a second end (82), and a center portion (84) interposed therebetween coupled to the mounting base and extending therefrom.

Abstract: A shaft assembly is provided to reduce breathing mode vibrations and resulting noises. The shaft assembly includes a shaft member having an outer surface and a damping member constructed at least in part from a damping material and including a substantially annular body and generally opposing ends. The opposing ends are biased such that at least a portion of the damping member engages with the shaft member.

Abstract: A shaft assembly includes a shaft member having an inside surface and defined by an axis, an absorber assembly disposed within the shaft member and including a cantilever device spacing a mass member away from a base and including damping material disposed around the cantilever device.

Abstract: A shaft assembly includes a shaft member having an inside surface and defined by an axis, an absorber assembly disposed within the shaft member and including a cantilever device spacing a mass member away from a base and including damping material disposed around the cantilever device.

Abstract: A vehicle driveline includes a tubular member (62) having an inside surface (64) and an axis, a mounting base (72) coupled to the tubular member (62), and a plurality of resonator members (74) each having a first end (80), a second end (82), and a center portion (84) interposed therebetween coupled to the mounting base and extending therefrom.

Abstract: A fastening device consisting of a first bar and a second bar. The first bar has an interior channel and a longitudinally extending groove communicating with the interior channel. The groove has enlarged openings at spaced intervals. The second bar has a plurality of tongues extending substantially perpendicularly and terminating with an enlarged appendage. The tongues are spaced at intervals corresponding to the interval spacing of the enlarged openings in the first bar. The appendages may be inserted through the openings into the channel and the tongues moved longitudinally along the groove to position the appendages out of register with the openings thereby coupling the second bar with the first bar.