Patents by Inventor Arthur Brace

Arthur Brace has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SLAMF1 ANTAGONISTS AND USES THEREOF
    Publication number: 20180016555
    Abstract: Methods of identifying and using SLAMF1 antagonists are provided.
    Type: Application
    Filed: October 21, 2015
    Publication date: January 18, 2018
    Applicant: Five Prime Therapeutics, Inc.
    Inventors: Luis Borges, Nathan Sallee, Charles Kaplan, Arthur Brace, W. Michael Kavanaugh, Brian Wong, David Bellovin, Thomas Brennan, Artur Karasyov
  • EEF2K as modifiers of the PTEN/AKT pathway and methods of use
    Patent number: 8679763
    Abstract: Human EEF2K genes are identified as modulators of the PTEN/AKT pathway and thus are therapeutic targets for disorders associated with defective PTEN/AKT function. Methods for identifying modulators of PTEN/AKT comprising screening for agents that modulate the activity of EEF2K are provided.
    Type: Grant
    Filed: March 10, 2006
    Date of Patent: March 25, 2014
    Assignee: Exelixis, Inc.
    Inventors: Arthur Brace, Robert A. Blake, Lori S. Friedman, Lynn Margaret Bjerke, Kevin M. Ward, Susana Nieto-Bergman
  • EYA2S As Modifiers of the PTEN/AKT Pathway and Methods of Use
    Publication number: 20110135629
    Abstract: Human MPTENAKT genes are identified as modulators of the PTEN/AKT pathway, and thus are therapeutic targets for disorders associated with defective PTEN/AKT function. Methods for identifying modulators of PTEN/AKT, comprising screening for agents that modulate the activity of MPTENAKT are provided.
    Type: Application
    Filed: June 20, 2006
    Publication date: June 9, 2011
    Applicant: EXELIXIS, INC.
    Inventors: Arthur Brace, Margaret Lynn Bjerke, Susana Nieto-Bergman, Lori S. Friedman, Kevin Ward, Robert A. Blake
  • GALK1S AS MODIFIERS OF THE PTEN/AKT PATHWAY AND METHODS OF USE
    Publication number: 20100183583
    Abstract: Human GALK1 genes are identified as modulators of the PTEN/AKT pathway, and thus are therapeutic targets for disorders associated with defective PTEN/AKT function. Methods for identifying modulators of PTEN/AKT, comprising screening for agents that modulate the activity of GALK1 are provided.
    Type: Application
    Filed: June 20, 2006
    Publication date: July 22, 2010
    Applicant: EXELIXIS, INC.
    Inventors: Arthur Brace, Margaret Lynn Bjerke, Susana Nieto-Bergman, Lori S. Friedman, Kevin Ward, Robert A. Blake
  • COMPOSITIONS AND METHODS FOR REGULATING COLLAGEN AND SMOOTH MUSCLE ACTIN EXPRESSION BY SERPINE2
    Publication number: 20100183620
    Abstract: The invention encompasses methods and compositions for increasing or decreasing collagen 1A1 expression and/or ?-smooth muscle actin expression in lung fibroblasts using SERPINE2 and antagonists of SERPINE2. The invention also encompasses methods and compositions for increasing or decreasing the formation of myofibroblasts. The invention further provides methods and compositions for treatment of lung diseases, such as idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease.
    Type: Application
    Filed: November 25, 2009
    Publication date: July 22, 2010
    Inventors: KAUMUDI BHAWE, Elizabeth Bosch, Kathleen Boyle, Arthur Brace, Anuk Das, Francis Farrell, Pitchumani Sivakumar, Jeffrey Finer, Kristen Pierce, Kathleen M. Sullivan, Brian Wong
  • CDC6S AS MODIFIERS OF THE PTEN/AKT PATHWAY AND METHODS OF USE
    Publication number: 20100122354
    Abstract: Human CDC6 genes are identified as modulators of the PTEN/AKT pathway, and thus are therapeutic targets for disorders associated with defective PTEN/AKT function. Methods for identifying modulators of PTEN/AKT, comprising screening for agents that modulate the activity of CDC6 are provided.
    Type: Application
    Filed: June 20, 2006
    Publication date: May 13, 2010
    Applicant: EXELIXIS, INC.
    Inventors: Arthur Brace, Margaret Lynn Bjerke, Susana Nieto-Bergman, Lori S. Friedman, Kevin Ward, Robert A. Blake
  • Eef2k as Modifiers of the Pten/Akt Pathway and Methods of Use
    Publication number: 20080193438
    Abstract: Human EEF2K genes are identified as modulators of the PTEN/AKT pathway and thus are therapeutic targets for disorders associated with defective PTEN/AKT function. Methods for identifying modulators of PTEN/AKT comprising screening for agents that modulate the activity of EEF2K are provided.
    Type: Application
    Filed: March 10, 2006
    Publication date: August 14, 2008
    Applicant: EXELIXIS INC.
    Inventors: Arthur Brace, Robert A. Blake, Lori S. Friedman, Lynn Margaret Bjerke, Kevin M. Ward, Susana Nieto-Bergman
  • Minrs as modifiers of insulin receptor signaling and methods of use
    Publication number: 20060088829
    Abstract: Human MINR genes are identified as modulators of INR signaling and thus are therapeutic targets for disorders associated with defective INR signaling. Methods for identifying modulators of MINR, comprising screening for agents that modulate the activity of MINR are provided.
    Type: Application
    Filed: February 5, 2003
    Publication date: April 27, 2006
    Inventors: Arthur Brace, Agnes Eliares, Kimberly Ferguson, Cynthia Seidel-Dugan, Felipa Mapa, Donald Ruhrmund, Jianfeng Wu
  • Methods for dissolving volatile addition agents in molten metal
    Patent number: 4057420
    Abstract: Methods and apparatus for introducing addition agents into molten metal retained in a vessel include providing a wire comprised of a metallic sheath encapsulating powdered and/or solid addition agents, preheating the wire with a controlled electrical current while feeding the preheated wire into the molten metal such that the metal sheath and addition agents melt before the wire contacts a vessel wall and the addition agents homogeneously dissolve at a predetermined rate in the molten metal. Also, the addition agents may be selected so as to react with impurities such as oxygen, sulfur, etc. to enable the removal thereof from the molten metal.
    Type: Grant
    Filed: February 6, 1976
    Date of Patent: November 8, 1977
    Assignee: Airco, Inc.
    Inventors: Arthur A. Brace, Alexander Lesnewich