Patents by Inventor Arthur C. Hewig, III

Arthur C. Hewig, III has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process control systems and methods for use with filters and filtration processes
    Patent number: 11786866
    Abstract: Systems and methods used to control tangential flow filtration are provided, including control systems and methods for use with connected systems with upstream processing units, such as chromatography processing units, in fluid communication with a tangential flow filtration processing unit. Also included are control systems and methods for performing continuous concentration using single-pass tangential flow filtration with permeate flow control.
    Type: Grant
    Filed: June 29, 2021
    Date of Patent: October 17, 2023
    Assignee: AMGEN INC.
    Inventors: Eva Gefroh, Randolph W. Schweickart, Krista Petty, Gregory Frank, Christine Salstrom Terpsma, Arthur C. Hewig, III, Joseph Edward Shultz
  • Method for using light scattering in real time to directly monitor and control impurity removal in purification processes
    Patent number: 11486883
    Abstract: The invention provides a method for controlling contaminants in biopharmaceutical purification processes by using light scattering and UV absorbance to establish a determinant. The invention makes use of multi-angle light scattering (MALS) and UV as a continuous monitoring system to provide information about the elution peak fractions in real-time instead of conventional pooling methods that rely on a predetermined percent UV peak max value to initiate the pooling process; regardless of product quality.
    Type: Grant
    Filed: September 23, 2019
    Date of Patent: November 1, 2022
    Assignee: AMGEN INC.
    Inventors: Arthur C. Hewig, III, Duke H. Phan, Yinges Yigzaw, Robert Bailey
  • Method for using light scattering in real time to directly monitor and control impurity removal in purification processes
    Patent number: 11293930
    Abstract: The invention provides a method for controlling contaminants in biopharmaceutical purification processes by using light scattering and UV absorbance to establish a determinant. The invention makes use of multi-angle light scattering (MALS) and UV as a continuous monitoring system to provide information about the elution peak fractions in real-time instead of conventional pooling methods that rely on a predetermined percent UV peak max value to initiate the pooling process; regardless of product quality.
    Type: Grant
    Filed: October 7, 2021
    Date of Patent: April 5, 2022
    Assignee: AMGEN INC.
    Inventors: Arthur C. Hewig, III, Duke H. Phan, Yinges Yigzaw, Robert Bailey
  • METHOD FOR USING LIGHT SCATTERING IN REAL TIME TO DIRECTLY MONITOR AND CONTROL IMPURITY REMOVAL IN PURIFICATION PROCESSES
    Publication number: 20220026442
    Abstract: The invention provides a method for controlling contaminants in biopharmaceutical purification processes by using light scattering and UV absorbance to establish a determinant. The invention makes use of multi-angle light scattering (MALS) and UV as a continuous monitoring system to provide information about the elution peak fractions in real-time instead of conventional pooling methods that rely on a predetermined percent UV peak max value to initiate the pooling process; regardless of product quality.
    Type: Application
    Filed: October 7, 2021
    Publication date: January 27, 2022
    Applicant: AMGEN INC.
    Inventors: Arthur C. HEWIG, III, Duke H. PHAN, Yinges YIGZAW, Robert BAILEY
  • PROCESS CONTROL SYSTEMS AND METHODS FOR USE WITH FILTERS AND FILTRATION PROCESSES
    Publication number: 20210339196
    Abstract: Systems and methods used to control tangential flow filtration are provided, including control systems and methods for use with connected systems with upstream processing units, such as chromatography processing units, in fluid communication with a tangential flow filtration processing unit. Also included are control systems and methods for performing continuous concentration using single-pass tangential flow filtration with permeate flow control.
    Type: Application
    Filed: June 29, 2021
    Publication date: November 4, 2021
    Inventors: Eva Gefroh, Randolph W. Schweickart, Krista Petty, Gregory Frank, Christine Salstrom Terpsma, Arthur C. Hewig, III, Joseph Edward Shultz
  • Process control systems and methods for use with filters and filtration processes
    Patent number: 11077404
    Abstract: Systems and methods used to control tangential flow filtration are provided, including control systems and methods for use with connected systems with upstream processing units, such as chromatography processing units, in fluid communication with a tangential flow filtration processing unit. Also included are control systems and methods for performing continuous concentration using single-pass tangential flow filtration with permeate flow control.
    Type: Grant
    Filed: January 15, 2020
    Date of Patent: August 3, 2021
    Assignee: AMGEN INC.
    Inventors: Eva Gefroh, Randolph W. Schweickart, Krista Petty, Gregory Frank, Christine Salstrom Terpsma, Arthur C. Hewig, III, Joseph Edward Shultz
  • PROCESS CONTROL SYSTEMS AND METHODS FOR USE WITH FILTERS AND FILTRATION PROCESSES
    Publication number: 20200147550
    Abstract: Systems and methods used to control tangential flow filtration are provided, including control systems and methods for use with connected systems with upstream processing units, such as chromatography processing units, in fluid communication with a tangential flow filtration processing unit. Also included are control systems and methods for performing continuous concentration using single-pass tangential flow filtration with permeate flow control.
    Type: Application
    Filed: January 15, 2020
    Publication date: May 14, 2020
    Inventors: Eva Gefroh, Randolph W. Schweickart, Krista Petty, Gregory Frank, Christine Salstrom Terpsma, Arthur C, Hewig, III, Joseph Edward Shultz
  • Process control systems and methods for use with filters and filtration processes
    Patent number: 10583397
    Abstract: Systems and methods used to control tangential flow filtration are provided, including control systems and methods for use with connected systems with upstream processing units, such as chromatography processing units, in fluid communication with a tangential flow filtration processing unit. Also included are control systems and methods for performing continuous concentration using single-pass tangential flow filtration with permeate flow control.
    Type: Grant
    Filed: May 13, 2015
    Date of Patent: March 10, 2020
    Assignee: AMGEN INC.
    Inventors: Eva Gefroh, Randolph W. Schweickart, Krista Petty, Gregory Frank, Christine Salstrom Terpsma, Arthur C. Hewig, III, Joseph Edward Shultz
  • METHOD FOR USING LIGHT SCATTERING IN REAL TIME TO DIRECTLY MONITOR AND CONTROL IMPURITY REMOVAL IN PURIFICATION PROCESSES
    Publication number: 20200018771
    Abstract: The invention provides a method for controlling contaminants in biopharmaceutical purification processes by using light scattering and UV absorbance to establish a determinant. The invention makes use of multi-angle light scattering (MALS) and UV as a continuous monitoring system to provide information about the elution peak fractions in real-time instead of conventional pooling methods that rely on a predetermined percent UV peak max value to initiate the pooling process; regardless of product quality.
    Type: Application
    Filed: September 23, 2019
    Publication date: January 16, 2020
    Applicant: AMGEN INC.
    Inventors: Arthur C. HEWIG III, Duke H. PHAN, Yinges YIGZAW, Robert BAILEY
  • Method for using light scattering in real time to directly monitor and control impurity removal in purification processes
    Patent number: 10481164
    Abstract: The invention provides a method for controlling contaminants in biopharmaceutical purification processes by using light scattering and UV absorbance to establish a determinant. The invention makes use of multi-angle light scattering (MALS) and UV as a continuous monitoring system to provide information about the elution peak fractions in real-time instead of conventional pooling methods that rely on a predetermined percent UV peak max value to initiate the pooling process; regardless of product quality.
    Type: Grant
    Filed: March 26, 2013
    Date of Patent: November 19, 2019
    Assignee: AMGEN INC.
    Inventors: Arthur C. Hewig, III, Duke H. Phan, Yinges Yigzaw, Robert Bailey
  • PROCESS CONTROL SYSTEMS AND METHODS FOR USE WITH FILTERS AND FILTRATION PROCESSES
    Publication number: 20170157566
    Abstract: Systems and methods used to control tangential flow filtration are provided, including control systems and methods for use with connected systems with upstream processing units, such as chromatography processing units, in fluid communication with a tangential flow filtration processing unit. Also included are control systems and methods for performing continuous concentration using single-pass tangential flow filtration with permeate flow control.
    Type: Application
    Filed: May 13, 2015
    Publication date: June 8, 2017
    Applicant: AMGEN INC.
    Inventors: Eva Gefroh, Randolph W. Schweickart, Krista Petty, Gregory Frank, Christine Salstrom Terpsma, Arthur C. Hewig, III, Joseph Edward Shultz
  • METHOD FOR USING LIGHT SCATTERING IN REAL TIME TO DIRECTLY MONITOR AND CONTROL IMPURITY REMOVAL IN PURIFICATION PROCESSES
    Publication number: 20130303732
    Abstract: The invention provides a method for controlling contaminants in biopharmaceutical purification processes by using light scattering and UV absorbance to establish a determinant. The invention makes use of multi-angle light scattering (MALS) and UV as a continuous monitoring system to provide information about the elution peak fractions in real-time instead of conventional pooling methods that rely on a predetermined percent UV peak max value to initiate the pooling process; regardless of product quality.
    Type: Application
    Filed: March 26, 2013
    Publication date: November 14, 2013
    Inventors: Arthur C. Hewig, III, Duke H. Phan, Yinges Yigzaw, Robert Bailey