Patents by Inventor Arthur Castle
Arthur Castle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7590493Abstract: The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.Type: GrantFiled: February 17, 2005Date of Patent: September 15, 2009Assignee: Ocimum Biosolutions, Inc.Inventors: Donna Mendrick, Mark Porter, Kory Johnson, Brandon Higgs, Arthur Castle, Michael Elashoff
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Publication number: 20090220970Abstract: The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.Type: ApplicationFiled: October 22, 2008Publication date: September 3, 2009Inventors: Donna Mendrick, Mark Porter, Kory Johnson, Brandon Higgs, Arthur Castle, Michael Elashoff
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Patent number: 7447594Abstract: The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known cardiotoxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.Type: GrantFiled: January 8, 2003Date of Patent: November 4, 2008Assignee: Ocimum Biosolutions, Inc.Inventors: Donna L. Mendrick, Mark W. Porter, Kory R. Johnson, Brandon Higgs, Arthur Castle, Michael Elashoff
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Patent number: 7426441Abstract: The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known renal toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.Type: GrantFiled: January 18, 2005Date of Patent: September 16, 2008Assignee: Ocimum Biosolutions, Inc.Inventors: Donna Mendrick, Mark Porter, Kory Johnson, Brandon Higgs, Arthur Castle, Michael Elashoff
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Patent number: 7415358Abstract: The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known renal toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.Type: GrantFiled: May 22, 2002Date of Patent: August 19, 2008Assignee: Ocimum Biosolutions, Inc.Inventors: Donna Mendrick, Mark Porter, Kory Johnson, Brandon Higgs, Arthur Castle, Michael Elashoff
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Publication number: 20070124086Abstract: The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in kidney tissues or cells exposed to a known renal toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.Type: ApplicationFiled: December 21, 2006Publication date: May 31, 2007Inventors: Donna Mendrick, Mark Porter, Kory Johnson, Arthur Castle, Brandon Higgs, Michael Elashoff
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Publication number: 20070093969Abstract: The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in kidney tissues or cells exposed to a known renal toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.Type: ApplicationFiled: November 24, 2003Publication date: April 26, 2007Inventors: Donna Mendrick, Mark Porter, Kory Johnson, Arthur Castle, Brandon Higgs, Michael Elashoff
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Publication number: 20070082332Abstract: The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known cardiotoxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.Type: ApplicationFiled: January 8, 2003Publication date: April 12, 2007Inventors: Donna Mendrick, Mark Porter, Kory Johnson, Brandon Higgs, Arthur Castle, Michael Elashoff
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Publication number: 20070061086Abstract: The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known cardiotoxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.Type: ApplicationFiled: November 17, 2006Publication date: March 15, 2007Inventors: Donna Mendrick, Mark Porter, Kory Johnson, Brandon Higgs, Arthur Castle, Michael Elashoff
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Publication number: 20070054269Abstract: The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known cardiotoxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.Type: ApplicationFiled: January 8, 2004Publication date: March 8, 2007Inventors: Donna Mendrick, Mark Porter, Kory Johnson, Brandon Higgs, Arthur Castle, Michael Elashoff
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Publication number: 20070055448Abstract: The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known toxin. The genes and their encoded proteins may be used as toxicity markers in drug screening and toxicity assays. The invention also includes a database of genes and/or proteins characterized by toxin-induced differential expression.Type: ApplicationFiled: August 9, 2004Publication date: March 8, 2007Applicant: Gene Logic Inc.Inventors: Donna Mendrick, Mark Porter, Kory Johnson, Brandon Higgs, Arthur Castle, Michael Orr, Michael Elashoff
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Publication number: 20070043515Abstract: The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.Type: ApplicationFiled: February 17, 2005Publication date: February 22, 2007Inventors: Donna Mendrick, Mark Porter, Kory Johnson, Brandon Higgs, Arthur Castle, Michael Elashoff
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Publication number: 20070027634Abstract: The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in liver tissues or cells exposed to a known toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by liver toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.Type: ApplicationFiled: January 31, 2003Publication date: February 1, 2007Inventors: Donna Mendrick, Mark Porter, Kory Johnson, Brandon Higgs, Arthur Castle, Michael Elashoff
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Publication number: 20070015146Abstract: The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in kidney tissues or cells exposed to a known renal toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.Type: ApplicationFiled: November 22, 2002Publication date: January 18, 2007Inventors: Donna Mendrick, Mark Porter, Kory Johnson, Arthur Castle, Brandon Higgs, Michael Elashoff
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Publication number: 20070015147Abstract: The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.Type: ApplicationFiled: February 4, 2003Publication date: January 18, 2007Inventors: Donna Mendrick, Mark Porter, Kory Johnson, Brandon Higgs, Arthur Castle, Michael Orr, Michael Elashoff
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Publication number: 20060078900Abstract: The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known renal toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.Type: ApplicationFiled: January 18, 2005Publication date: April 13, 2006Inventors: Donna Mendrick, Mark Porter, Kory Johnson, Brandon Higgs, Arthur Castle, Michael Elashoff
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Publication number: 20040072160Abstract: The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known renal toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.Type: ApplicationFiled: May 22, 2002Publication date: April 15, 2004Inventors: Donna Mendrick, Mark Porter, Kory Johnson, Brandon Higgs, Arthur Castle, Michael Elashoff
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Publication number: 20040043405Abstract: The present invention includes methods of identifying genes whose expression level is invariant among cell or tissue types. The methods of the invention can be used in the diagnosis of disease, in quality control in evaluating external data or databases, and in normalization of external data for comparative purposes. The genes of the invention can be used to produce microarrays that generate data with improved reliability.Type: ApplicationFiled: July 17, 2003Publication date: March 4, 2004Applicant: Gene Logic, Inc.Inventors: Arthur Castle, Brandon Higgs, Michael Elashoff, Mark Porter
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Publication number: 20040014040Abstract: The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known cardiotoxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.Type: ApplicationFiled: July 10, 2002Publication date: January 22, 2004Inventors: Donna Mendrick, Mark Porter, Kory Johnson, Brandon Higgs, Arthur Castle, Michael Elashoff
