Patents by Inventor Arthur Charles Ley
Arthur Charles Ley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11344610Abstract: Methods are described for preventing or reducing ischemia and/or systemic inflammatory response in a patient such as perioperative blood loss and/or systemic inflammatory response in a patient subjected to cardiothoracic surgery, e.g. coronary artery bypass grafting and other surgical procedures, especially when such procedures involve extra-corporeal circulation, such as cardiopulmonary bypass.Type: GrantFiled: February 21, 2019Date of Patent: May 31, 2022Assignee: Takeda Pharmaceutical Company LimitedInventors: Robert Charles Ladner, Arthur Charles Ley, Shirish Hirani, Anthony Williams
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Publication number: 20190247477Abstract: Methods are described for preventing or reducing ischemia and/or systemic inflammatory response in a patient such as perioperative blood loss and/or systemic inflammatory response in a patient subjected to cardiothoracic surgery, e.g. coronary artery bypass grafting and other surgical procedures, especially when such procedures involve extra-corporeal circulation, such as cardiopulmonary bypass.Type: ApplicationFiled: February 21, 2019Publication date: August 15, 2019Applicant: Dyax Corp.Inventors: Robert Charles Ladner, Arthur Charles Ley, Shirish Hirani, Anthony Williams
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Patent number: 10245307Abstract: Methods are described for preventing or reducing ischemia and/or systemic inflammatory response in a patient such as perioperative blood loss and/or systemic inflammatory response in a patient subjected to cardiothoracic surgery, e.g. coronary artery bypass grafting and other surgical procedures, especially when such procedures involve extra-corporeal circulation, such as cardiopulmonary bypass.Type: GrantFiled: June 7, 2016Date of Patent: April 2, 2019Assignee: Dyax Corp.Inventors: Robert Charles Ladner, Arthur Charles Ley, Shirish Hirani, Anthony Williams
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Publication number: 20160361395Abstract: Methods are described for preventing or reducing ischemia and/or systemic inflammatory response in a patient such as perioperative blood loss and/or systemic inflammatory response in a patient subjected to cardiothoracic surgery, e.g. coronary artery bypass grafting and other surgical procedures, especially when such procedures involve extra-corporeal circulation, such as cardiopulmonary bypass.Type: ApplicationFiled: June 7, 2016Publication date: December 15, 2016Applicant: Dyax Corp.Inventors: Robert Charles Ladner, Arthur Charles Ley, Shirish Hirani, Anthony Williams
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Patent number: 7893007Abstract: In order to obtain a novel binding protein against a chosen target, DNA molecules, each encoding a protein comprising one of a family of similar potential binding domains and a structural signal calling for the display of the protein on the outer surface of a chosen bacterial cell, bacterial spore or phage (genetic package) are introduced into a genetic package. The protein is expressed and the potential binding domain is displayed on the outer surface of the package. The cells or viruses bearing the binding domains which recognize the target molecule are isolated and amplified. The successful binding domains are then characterized. One or more of these successful binding domains is used as a model for the design of a new family of potential binding domains, and the process is repeated until a novel binding domain having a desired affinity for the target molecule is obtained.Type: GrantFiled: October 22, 2008Date of Patent: February 22, 2011Assignee: Dyax Corp.Inventors: Robert Charles Ladner, Sonia Kosow Guterman, Bruce Lindsay Roberts, William Markland, Arthur Charles Ley, Rachel Baribault Kent
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Publication number: 20090234101Abstract: In order to obtain a novel binding protein against a chosen target, DNA molecules, each encoding a protein comprising one of a family of similar potential binding domains and a structural signal calling for the display of the protein on the outer surface of a chosen bacterial cell, bacterial spore or phage (genetic package) are introduced into a genetic package. The protein is expressed and the potential binding domain is displayed on the outer surface of the package. The cells or viruses bearing the binding domains which recognize the target molecule are isolated and amplified. The successful binding domains are then characterized. One or more of these successful binding domains is used as a model for the design of a new family of potential binding domains, and the process is repeated until a novel binding domain having a desired affinity for the target molecule is obtained.Type: ApplicationFiled: October 22, 2008Publication date: September 17, 2009Applicant: DYAX CORP.Inventors: ROBERT CHARLES LADNER, SONIA KOSOW GUTERMAN, BRUCE LINDSY ROBERTS, WILLIAM MARKLAND, ARTHUR CHARLES LEY, RACHEL BARIBAULT KENT
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Patent number: 7413537Abstract: The invention relates, in part, to a library of chimeric proteins, each chimeric protein including a mini-protein between about eight and about forty amino acids long, wherein the mini-protein has a single disulfide bond formed by a pair of invariant cysteines and has only two cysteines. The chimeric protein also includes at least a portion of an outer surface protein of a genetic package, wherein the chimeric protein is displayed on the outer surface of the genetic package. The invention also includes, in part, a mixture of nucleic acids that encode a library of the invention. The invention also includes, in part, a process for identifying proteins with a desired binding activity against a target, the process including screening a library of chimeric proteins of the invention; and identifying the chimeric protein. The invention, in part, also includes chimeric proteins expressed by a library of the invention.Type: GrantFiled: July 31, 2002Date of Patent: August 19, 2008Assignee: Dyax Corp.Inventors: Robert Charles Ladner, Sonia Kosow Guterman, Bruce Lindsay Roberts, William Markland, Arthur Charles Ley, Rachel Baribault Kent
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Patent number: 7208293Abstract: In order to obtain a novel binding protein against a chosen target, DNA molecules, each encoding a protein comprising one of a family of similar potential binding domains and a structural signal calling for the display of the protein on the outer surface of a chosen bacterial cell, bacterial spore or phage (genetic package) are introduced into a genetic package. The protein is expressed and the potential binding domain is displayed on the outer surface of the package. The cells or viruses bearing the binding domains which recognize the target molecule are isolated and amplified. The successful binding domains are then characterized. One or more of these successful binding domains is used as a model for the design of a new family of potential binding domains, and the process is repeated until a novel binding domain having a desired affinity for the target molecule is obtained.Type: GrantFiled: June 29, 2001Date of Patent: April 24, 2007Assignee: Dyax Corp.Inventors: Robert Charles Ladner, Sonia Kosow Guterman, Bruce Lindsay Roberts, William Markland, Arthur Charles Ley, Rachel Baribault Kent
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Patent number: 7118879Abstract: In order to obtain a novel binding protein against a chosen target, DNA molecules, each encoding a protein comprising one of a family of similar potential binding domains and a structural signal calling for the display of the protein on the outer surface of a chosen bacterial cell, bacterial spore or phage (genetic package) are introduced into a genetic package. The protein is expressed and the potential binding domain is displayed on the outer surface of the package. The cells or viruses bearing the binding domains which recognize the target molecule are isolated and amplified. The successful binding domains are then characterized. One or more of these successful binding domains is used as a model for the design of a new family of potential binding domains, and the process is repeated until a novel binding domain having a desired affinity for the target molecule is obtained.Type: GrantFiled: April 22, 2002Date of Patent: October 10, 2006Assignee: Dyax Corp.Inventors: Robert Charles Ladner, Sonia Kosow Guterman, Bruce Lindsay Roberts, William Markland, Arthur Charles Ley, Rachel Baribault Kent
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Patent number: 6979538Abstract: In order to obtain a novel binding protein against a chosen target, DNA molecules, each encoding a protein comprising one of a family of similar potential binding domains and a structural signal calling for the display of the protein on the outer surface of a chosen bacterial cell, bacterial spore or phage (genetic package) are introduced into a genetic package. The protein is expressed and the potential binding domain is displayed on the outer surface of the package. The cells or viruses bearing the binding domains which recognize the target molecule are isolated and amplified. The successful binding domains are then characterized. One or more of these successful binding domains is used as a model for the design of a new family of potential binding domains, and the process is repeated until a novel binding domain having a desired affinity for the target molecule is obtained.Type: GrantFiled: February 14, 2001Date of Patent: December 27, 2005Assignee: Dyax Corp.Inventors: Robert Charles Ladner, Sonia Kosow Guterman, Bruce Lindsay Roberts, William Markland, Arthur Charles Ley, Rachel Baribault Kent
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Patent number: 6906176Abstract: Novel enterokinase cleavage sequences are provided. Also disclosed are methods for the rapid isolation of a protein of interest present in a fusion protein construct including a novel enterokinase cleavage sequence of the present invention and a ligand recognition sequence for capturing the fusion construct on a solid substrate. Preferred embodiments of the present invention show rates of cleavage up to thirty times that of the known enterokinase cleavage substrate (Asp)4-Lys-Ile.Type: GrantFiled: June 19, 2001Date of Patent: June 14, 2005Assignee: Dyax Corp.Inventors: Arthur Charles Ley, Christopher Jon Luneau, Robert Charles Ladner
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Publication number: 20040023205Abstract: In order to obtain a novel binding protein against a chosen target, DNA molecules, each encoding a protein comprising one of a family of similar potential binding domains and a structural signal calling for the display of the protein on the outer surface of a chosen bacterial cell, bacterial spore or phage (genetic package) are introduced into a genetic package. The protein is expressed and the potential binding domain is displayed on the outer surface of the package. The cells or viruses bearing the binding domains which recognize the target molecule are isolated and amplified. The successful binding domains are then characterized. One or more of these successful binding domains is used as a model for the design of a new family of potential binding domains, and the process is repeated until a novel binding domain having a desired affinity for the target molecule is obtained.Type: ApplicationFiled: April 22, 2002Publication date: February 5, 2004Inventors: Robert Charles Ladner, Sonia Kosow Guterman, Bruce Lindsay Roberts, William Markland, Arthur Charles Ley, Rachel Baribault Kent
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Publication number: 20040005539Abstract: In order to obtain a novel binding protein against a chosen target, DNA molecules, each encoding a protein comprising one of a family of similar potential binding domains and a structural signal calling for the display of the protein on the outer surface of a chosen bacterial cell, bacterial spore or phage (genetic package) are introduced into a genetic package. The protein is expressed and the potential binding domain is displayed on the outer surface of the package. The cells or viruses bearing the binding domains which recognize the target molecule are isolated and amplified. The successful binding domains are then characterized. One or more of these successful binding domains is used as a model for the design of a new family of potential binding domains, and the process is repeated until a novel binding domain having a desired affinity for the target molecule is obtained.Type: ApplicationFiled: April 22, 2002Publication date: January 8, 2004Inventors: Robert Charles Ladner, Sonia Kosow Guterman, Bruce Lindsay Roberts, William Markland, Arthur Charles Ley, Rachel Baribault Kent
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Publication number: 20030223977Abstract: Novel small proteins which bind cathepsin G have been identified. These are useful as inhibitors of excessive cathepsin G activity in patients.Type: ApplicationFiled: April 4, 2002Publication date: December 4, 2003Inventors: Arthur Charles Ley, Sonia Kosow Guterman, William Markland, Rachel Baribault Kent, Bruce Lindsay Roberts, Robert Charles Ladner
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Publication number: 20030219722Abstract: In order to obtain a novel binding protein against a chosen target, DNA molecules, each encoding a protein comprising one of a family of similar potential binding domains and a structural signal calling for the display of the protein on the outer surface of a chosen bacterial cell, bacterial spore or phage (genetic package) are introduced into a genetic package. The protein is expressed and the potential binding domain is displayed on the outer surface of the package. The cells or viruses bearing the binding domains which recognize the target molecule are isolated and amplified. The successful binding domains are then characterized. One or more of these successful binding domains is used as a model for the design of a new family of potential binding domains, and the process is repeated until a novel binding domain having a desired affinity for the target molecule is obtained.Type: ApplicationFiled: April 22, 2002Publication date: November 27, 2003Inventors: Robert Charles Ladner, Sonia Kosow Guterman, Bruce Lindsay Roberts, William Markland, Arthur Charles Ley, Rachel Baribault Kent
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Publication number: 20030219886Abstract: In order to obtain a novel binding protein against a chosen target, DNA molecules, each encoding a protein comprising one of a family of similar potential binding domains and a structural signal calling for the display of the protein on the outer surface of a chosen bacterial cell, bacterial spore or phage (genetic package) are introduced into a genetic package. The protein is expressed and the potential binding domain is displayed on the outer surface of the package. The cells or viruses bearing the binding domains which recognize the target molecule are isolated and amplified. The successful binding domains are then characterized. One or more of these successful binding domains is used as a model for the design of a new family of potential binding domains, and the process is repeated until a novel binding domain having a desired affinity for the target molecule is obtained.Type: ApplicationFiled: June 29, 2001Publication date: November 27, 2003Inventors: Robert Charles Ladner, Sonia Kosow Guterman, Bruce Lindsay Roberts, William Markland, Arthur Charles Ley, Rachel Baribault Kent
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Publication number: 20030175919Abstract: Mutants of Kunitz domain 1 (ITI-D1) of human inter-&agr;-trypsin inhibitor (ITI), are useful as inhibitors of human neutrophil elastase. Mutants characterized by one or more of the following substitutions (numbered to correspond to bovine pancreatic trypsin inhibitor, the archetypal Kunitz domain) are of particular interest: (a) Val15 or Ile15, (b) Ala16, (c) Phe18, (d) Pro19, (e) Arg1, (f) Pro2, and/or (g) Phe4.Type: ApplicationFiled: January 8, 2002Publication date: September 18, 2003Inventors: Arthur Charles Ley, Sonia Kosow Guterman, William Markland, Rachel Baribault Kent, Bruce Lindsay Roberts, Robert Charles Ladner
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Publication number: 20030113717Abstract: In order to obtain a novel binding protein against a chosen target, DNA molecules, each encoding a protein comprising one of a family of similar potential binding domains and a structural-signal calling for the display of the protein on the outer surface of a chosen bacterial cell, bacterial spore or phage (genetic package) are introduced into a genetic package. The protein is expressed and the potential binding domain is displayed on the outer surface of the package. The cells or viruses bearing the binding domains which recognize the target molecule are isolated and amplified. The successful binding domains are then characterized. One or more of these successful binding domains is used as a model for the design of a new family of potential binding domains, and the process is repeated until a novel binding domain having a desired affinity for the target molecule is obtained.Type: ApplicationFiled: June 29, 2001Publication date: June 19, 2003Inventors: Robert Charles Ladner, Sonia Kosow Guterman, Bruce Lindsay Roberts, William Markland, Arthur Charles Ley, Rachel Baribault Kent
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Publication number: 20020192789Abstract: Novel enterokinase cleavage sequences are provided. Also disclosed are methods for the rapid isolation of a protein of interest present in a fusion protein construct including a novel enterokinase cleavage sequence of the present invention and a ligand recognition sequence for capturing the fusion construct on a solid substrate. Preferred embodiments of the present invention show rates of cleavage up to thirty times that of the known enterokinase cleavage substrate (Asp)4-Lys-Ile.Type: ApplicationFiled: June 19, 2001Publication date: December 19, 2002Inventors: Arthur Charles Ley, Christopher Jon Luneau, Robert Charles Ladner
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Publication number: 20020150881Abstract: In order to obtain a novel binding protein against a chosen target, DNA molecules, each encoding a protein comprising one of a family of similar potential binding domains and a structural signal calling for the display of the protein on the outer surface of a chosen bacterial cell, bacterial spore or phage (genetic package) are introduced into a genetic package. The protein is expressed and the potential binding domain is displayed on the outer surface of the package. The cells or viruses bearing the binding domains which recognize the target molecule are isolated and amplified. The successful binding domains are then characterized. One or more of these successful binding domains is used as a model for the design of a new family of potential binding domains, and the process is repeated until a novel binding domain having a desired affinity for the target molecule is obtained.Type: ApplicationFiled: February 14, 2001Publication date: October 17, 2002Inventors: Robert Charles Ladner, Sonia Kosow Guterman, Bruce Lindsay Roberts, William Markland, Arthur Charles Ley, Rachel Baribault Kent