Patents by Inventor Arthur D. Broom

Arthur D. Broom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Amphipathic oligonucleotides and polynucleotides having potent antiviral activity
    Patent number: 6130324
    Abstract: The present invention provides novel compositions that show potent antiviral activity against both DNA and RNA viruses. In particular, the present invention provides oligo- and polyribonucleotides with potent antiviral activity against HIV and HCMV. These compositions are thought to operate in a novel fashion at an early stage of viral infection, meeting the need for alternatives or synergistic therapies to the toxic treatments currently available. The present invention also discloses methods for synthesizing oligo- and polyribonucleotides showing antiviral activity.
    Type: Grant
    Filed: August 10, 1999
    Date of Patent: October 10, 2000
    Assignee: University of Utah Research Foundation
    Inventors: Arthur D. Broom, Robyn Thorpe
  • Oligonucleotides containing n-methyl thiolated bases having antiviral activity
    Patent number: 5652359
    Abstract: Oligonucleotides containing 1-N-alkyl-6-thiopurine, 3-N-alkyl-4-thiopyrimidine and 5-N-alkyl-4-thiopyrazolopyrimidine bases and the corresponding 2'-O-alkylated or allylated nucleotides demonstrate potent antiviral activity in several assays, including the human immunodeficiency virus reverse transcriptase enzyme assay. The oligonucleotides of the invention contain approximately 5 to 99 nucleotide units, and may include, in addition to the above-noted N-alkylated and thiolated heterocyclic bases, the naturally occurring pyrimidine and purine bases.
    Type: Grant
    Filed: December 2, 1993
    Date of Patent: July 29, 1997
    Assignee: Epoch Pharmaceuticals, Inc.
    Inventors: Rich B. Meyer, Jr., Alexander A. Gall, Arthur D. Broom