Patents by Inventor Arthur Dusty Miller

Arthur Dusty Miller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR GENERATING ADENO-ASSOCIATED VIRAL VECTORS WITH UNDETECTABLE CAPSID GENE CONTAMINATION
    Publication number: 20210010027
    Abstract: In one aspect, the present invention provides an intron-modified capsid expression cassette useful for generating adeno-associated virus (AAV) vector particles. In another aspect, the present invention provides a method of reducing the immune response in a mammalian subject undergoing treatment with an AAV vector.
    Type: Application
    Filed: July 30, 2020
    Publication date: January 14, 2021
    Applicant: Fred Hutchinson Cancer Research Center
    Inventors: Arthur Dusty Miller, Christine L. Halbert, Michael J. Metzger
  • Compositions and methods for generating adeno-associated viral vectors with undetectable capsid gene contamination
    Patent number: 10752915
    Abstract: In one aspect, the present invention provides an intron-modified capsid expression cassette useful for generating adeno-associated virus (AAV) vector particles. In another aspect, the present invention provides a method of reducing the immune response in a mammalian subject undergoing treatment with an AAV vector.
    Type: Grant
    Filed: March 17, 2016
    Date of Patent: August 25, 2020
    Assignee: Fred Hutchinson Cancer Research Center
    Inventors: Arthur Dusty Miller, Christine L. Halbert, Michael J. Metzger
  • Compositions and methods for generating adeno-associated viral vectors with undetectable capsid gene contamination
    Patent number: 10415056
    Abstract: In one aspect, the present invention provides an intron-modified cap expression cassette useful for generating adeno-associated virus (AAV) vector particles. In another aspect, the present invention provides a method of reducing the immune response in a mammalian subject undergoing treatment with an AAV vector.
    Type: Grant
    Filed: November 10, 2011
    Date of Patent: September 17, 2019
    Assignee: Fred Hutchinson Cancer Research Center
    Inventors: Arthur Dusty Miller, Christine L. Halbert, Michael J. Metzger
  • COMPOSITIONS AND METHODS FOR GENERATING ADENO-ASSOCIATED VIRAL VECTORS WITH UNDETECTABLE CAPSID GENE CONTAMINATION
    Publication number: 20160194664
    Abstract: In one aspect, the present invention provides an intron-modified capsid expression cassette useful for generating adeno-associated virus (AAV) vector particles. In another aspect, the present invention provides a method of reducing the immune response in a mammalian subject undergoing treatment with an AAV vector.
    Type: Application
    Filed: March 17, 2016
    Publication date: July 7, 2016
    Applicant: Fred Hutchinson Cancer Research Center
    Inventors: Arthur Dusty Miller, Christine L. Halbert, Michael J. Metzger
  • COMPOSITIONS AND METHODS FOR GENERATING ADENO-ASSOCIATED VIRAL VECTORS WITH UNDETECTABLE CAPSID GENE CONTAMINATION
    Publication number: 20130296409
    Abstract: In one aspect, the present invention provides an intron-modified cap expression cassette useful for generating adeno-associated virus (AAV) vector particles. In another aspect, the present invention provides a method of reducing the immune response in a mammalian subject undergoing treatment with an AAV vector.
    Type: Application
    Filed: November 10, 2011
    Publication date: November 7, 2013
    Applicant: FRED HUTCHINSON CANCER RESEARCH CENTER
    Inventors: Arthur Dusty Miller, Christine L. Halbert, Michael J. Metzger
  • Compositions and methods for efficient AAV vector production
    Patent number: 7208315
    Abstract: The present invention provides packaging cell lines for the efficient production of an Adeno-associated virus (AAV) vector which does not require “helper” virus function for the replication and encapsidation of the AAV vector particles. Packaging cells, methods for their production and methods for producing recombinant AAV vector particles useful for human gene therapy are provided.
    Type: Grant
    Filed: January 5, 2001
    Date of Patent: April 24, 2007
    Assignee: Fred Hutchinson Cancer Research Center
    Inventors: Arthur Dusty Miller, James M. Allen, Christine L. Halbert
  • Compositions and methods for efficient aav vector production
    Publication number: 20040248288
    Abstract: The present invention provides packaging cell lines for the efficient production of an Adeno-associated virus (AAV) vector which does not require “helper” virus function for the replication and encapsidation of the AAV vector particles. Packaging cells, methods for their production and methods for producing recombinant AAV vector particles useful for human gene therapy are provided.
    Type: Application
    Filed: November 4, 2002
    Publication date: December 9, 2004
    Inventors: Arthur Dusty Miller, James M. Allen, Christine L. Halbert
  • Jaagsiekte sheep retroviral packaging cell lines and methods relating thereto
    Publication number: 20030104357
    Abstract: The present invention demonstrates that JSRV envelope protein (Env) can be used to transduce human and other mammalian cells. Hybrid retrovirus packaging cells have been constructed that express the JSRV Env and retrovirus Gag-Pol proteins, and can produce JSRV-pseudotype vectors at high titers. Using high-titer virus the host range for JSRV has been established, and included sheep, human, monkey, bovine and dog cells, but not murine, rat or hamster cells. Retroviral packaging cell lines comprising the JSRV envelope protein, and receptor binding fragments thereof, are provided which transiently and stably produce high titers of recombinant retrovirus particles which can be used to transfer a heterologous gene to a eukaryotic cell.
    Type: Application
    Filed: March 29, 2002
    Publication date: June 5, 2003
    Applicant: Fred Hutchinson Cancer Research Center
    Inventors: Sharath K. Rai, Arthur Dusty Miller