Patents by Inventor Arthur F. Michaelis

Arthur F. Michaelis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Rifamycin analogs and uses thereof
    Patent number: 7220738
    Abstract: The present invention features rifamycin analogs that can be used as therapeutics for treating or preventing a variety of microbial infections. In one form, the analogs are acetylated at the 25-position, as is rifamycin. In another form, the analogs are deacetylated at the 25-position. In yet other forms, benzoxazinorifamycin, benzthiazinorifamycin, and benzdiazinorifamycin analogs are derivatized at various positions of the benzene ring, including 3?-hydroxy analogs, and/or various fused ring systems with the benzene ring at the 4?,5? or 5?,6? positions.
    Type: Grant
    Filed: December 9, 2004
    Date of Patent: May 22, 2007
    Assignee: ActivBiotics, Inc.
    Inventors: John H. van Duzer, Arthur F. Michaelis, William B. Geiss, Douglas G. Stafford, Xiang Y. Yu, James M. Siedlecki, Yingfei Yang
  • Targeted therapeutics and uses thereof
    Patent number: 7122525
    Abstract: The invention features a method of delivering a drug to a diseased cell by linking the drug to a rifamycin derivative, compositions that include drug-rifamycin conjugates of the invention, and methods for treating disease using those compositions.
    Type: Grant
    Filed: November 21, 2002
    Date of Patent: October 17, 2006
    Assignee: ActivBiotics, Inc.
    Inventors: Arthur F. Michaelis, Hawkins V. Maulding, Chalom Sayada, Congxiang Zha
  • Sulfhydryl rifamycins and uses thereof
    Patent number: 7078399
    Abstract: The invention features sulfhydryl rifamycin compositions, methods of making these compositions, and methods for treating disease using these compositions.
    Type: Grant
    Filed: December 12, 2002
    Date of Patent: July 18, 2006
    Assignee: ActivBiotics, Inc.
    Inventors: Arthur F. Michaelis, Hawkins V. Maulding, Chalom Sayada, Barry Eisenstein, William B. Geiss, Joseph Raker
  • Antimicrobial agents and uses thereof
    Patent number: 6900204
    Abstract: The invention features compounds that act as antimicrobial agents and/or antimicrobial enhancer agents, compositions that include the antimicrobial enhancer agents of the invention, and methods for treating microbial infections using those compositions.
    Type: Grant
    Filed: September 6, 2002
    Date of Patent: May 31, 2005
    Assignee: ActivBiotics, Inc.
    Inventors: Arthur F. Michaelis, Hawkins V. Maulding
  • Rifalazil compositions and therapeutic regimens
    Publication number: 20040157840
    Abstract: The invention features low-dosage rifalazil compositions and therapeutic regimens which are useful for the treatment of bacterial infections.
    Type: Application
    Filed: September 23, 2003
    Publication date: August 12, 2004
    Inventors: Bernard E. Cabana, Arthur F. Michaelis, Gary P. Magnant, Chalom B. Sayada
  • Methods and compositions for treating and preventing ear infections
    Publication number: 20040126414
    Abstract: The present invention relates to methods of treating, reducing, or preventing ear infections by topically administering a rifamycin of the invention to the ear of a patient. Infections amenable to treatment according to this invention include, for example, otitis media, otitis externa, or infections arising from surgery.
    Type: Application
    Filed: December 11, 2003
    Publication date: July 1, 2004
    Inventor: Arthur F. Michaelis
  • Targeted therapeutics and uses thereof
    Publication number: 20040063718
    Abstract: The invention features a method of delivering a drug to a diseased cell by linking the drug to a rifamycin derivative, compositions that include drug-rifamycin conjugates of the invention, and methods for treating disease using those compositions.
    Type: Application
    Filed: November 21, 2002
    Publication date: April 1, 2004
    Inventors: Arthur F. Michaelis, Hawkins V. Maulding, Chalom Sayada, Congxiang Zha
  • Intravenous rifalazil formulation and methods of use thereof
    Publication number: 20040034021
    Abstract: The invention features intravenous dosage formulations of rifalazil and methods of treating disease by intravenous administration of rifalazil.
    Type: Application
    Filed: June 3, 2003
    Publication date: February 19, 2004
    Inventors: Arthur F. Michaelis, Chalom Sayada, Bernard E. Cabana
  • Sulfhydryl rifamycins and uses thereof
    Publication number: 20040014749
    Abstract: The invention features sulfhydryl rifamycin compositions, methods of making these compositions, and methods for treating disease using these compositions.
    Type: Application
    Filed: December 12, 2002
    Publication date: January 22, 2004
    Inventors: Arthur F. Michaelis, Hawkins V. Maulding, Chalom Sayada, Barry Eisenstein, William B. Geiss, Joseph Raker
  • Metal complexes and formulations of rifamycin analogues and uses thereof
    Publication number: 20040014750
    Abstract: The invention features compositions that include rifamycin analogues formulated with metal salts, metal complexes of rifamycin analogues, and methods for treating disease using these compositions.
    Type: Application
    Filed: December 12, 2002
    Publication date: January 22, 2004
    Inventors: Arthur F. Michaelis, Hawkins V. Maulding, Chalom Sayada, Barry Eisenstein
  • Antimicrobial agents and uses thereof
    Publication number: 20030105086
    Abstract: The invention features compounds that act as antimicrobial agents and/or antimicrobial enhancer agents, compositions that include the antimicrobial enhancer agents of the invention, and methods for treating microbial infections using those compositions.
    Type: Application
    Filed: September 6, 2002
    Publication date: June 5, 2003
    Inventors: Arthur F. Michaelis, Hawkins V. Maulding
  • Methods for the preparation of controlled gastric residence time medicament formulations
    Patent number: 4088798
    Abstract: Controlled gastric residence time medicament formulations, e.g., tablets and/or capsules, containing polymeric film coatings are exposed to a volatile amine, e.g., anhydrous ammonia, methyl amine, or ethyl amine, to provide improved medicament formulations, which by virtue of mechanical or surface effects including expansion or swelling of the coating in gastric fluids are capable of prolonged, e.g., up to twelve hours, residence in the gastric area.
    Type: Grant
    Filed: November 23, 1976
    Date of Patent: May 9, 1978
    Assignee: Sandoz, Inc.
    Inventor: Arthur F. Michaelis