Abstract: This invention relates to FSH or a FSH variant containing an alpha and beta subunit contained in formulations, and articles of manufacture. The invention provides advantageous new proteins and nucleic acids, multi-use pharmaceutical solutions, formulations and products of said proteins and nucleic acids where none approved for commercial use had previously existed having such extended use indications. These products are particularly useful in therapeutic regimens for increasing serum levels of FSH or a FSH variant over a period of treatment. Thus, inter alia, the invention fills the need for convenient products of FSH or from a FSH variant.

Abstract: This invention relates to FSH or a FSH variant containing an alpha and beta subunit contained in formulations, and articles of manufacture. The invention provides advantageous new proteins and nucleic acids, multi-use pharmaceutical solutions, formulations and products of said proteins and nucleic acids where none approved for commercial use had previously existed having such extended use indications. These products are particularly useful in therapeutic regimens for increasing serum levels of FSH or a FSH variant over a period of treatment. Thus, inter alia, the invention fills the need for convenient products of FSH or from a FSH variant.

Abstract: This invention relates to FSH or a FSH variant containing an alpha and beta subunit contained in formulations, and articles of manufacture. The invention provides advantageous new proteins and nucleic acids, multi-use pharmaceutical solutions, formulations and products of said proteins and nucleic acids where none approved for commercial use had previously existed having such extended use indications. These products are particularly useful in therapeutic regimens for increasing serum levels of FSH or a FSH variant over a period of treatment.

Abstract: The invention provides a shoulder belt height adjuster assembly and a method of adjusting the same. The assembly includes a guide rail, a slide, and a biasing member. The guide rail includes a plurality of fixed rail teeth disposed along at least one longitudinal portion. The slide includes an aperture formed therein for slidably receiving the guide rail along the longitudinal portion. The slide further includes a plurality of fixed slide teeth disposed on an interior slide surface. The biasing member is operably attached to the slide aperture for selectively engaging at least one of the fixed slide teeth into at least one of the fixed rail teeth. The engagement prevents slidable movement of the slide relative to the guide rail in a downward direction.

Abstract: The invention provides a shoulder belt height adjuster assembly and a method of adjusting the same. The assembly includes a guide rail, a slide, and a biasing member. The guide rail includes a plurality of fixed rail teeth disposed along at least one longitudinal portion. The slide includes an aperture formed therein for slidably receiving the guide rail along the longitudinal portion. The slide further includes a plurality of fixed slide teeth disposed on an interior slide surface. The biasing member is operably attached to the slide aperture for selectively engaging at least one of the fixed slide teeth into at least one of the fixed rail teeth. The engagement prevents slidable movement of the slide relative to the guide rail in a downward direction.

Abstract: This invention relates to FSH or a FSH variant containing an alpha and beta subunit contained in formulations, and articles of manufacture. The invention provides advantageous new proteins and nucleic acids, multi-use pharmaceutical solutions, formulations and products of said proteins and nucleic acids where none approved for commercial use had previously existed having such extended use indications. These products are particularly useful in therapeutic regimens for increasing serum levels of FSH or a FSH variant over a period of treatment. Thus, inter alia, the invention fills the need for convenient products of FSH or from a FSH variant.

Abstract: A reactor for aerating a fluid with a gas comprises a mixing tank (12) for the fluid and a centrally located vertical draft tube (13) submerged in the fluid to divide the mixing tank (12) into an inner chamber (21) and an outer chamber (23). The reactor further comprises a motor driven axial flow impeller (14) located in the draft tube (13) for circulating fluid downwardly through the inner chamber (21) and upwardly through the outer chamber (23). The reactor further comprises an external circuit for withdrawing a portion of the fluid from the mixing tank (12), aerating the fluid, and returning the aerated fluid to the mixing tank (12). The aerator is in the form of a venturi device (17).

Abstract: The invention provides individual tetragonal flat rod shaped or plate-like crystals of glucagon-like peptide-1 related molecules, processes for their preparation, compositions and methods of use. The crystal preparations exhibit extended time action in vivo and are useful for treating diabetes, obesity and related conditions.

Abstract: The invention provides individual tetragonal flat rod shaped or plate-like crystals of glucagon-like peptide-1 related molecules, processes for their preparation, compositions and methods of use. The crystal preparations exhibit extended time action in vivo and are useful for treating diabetes, obesity and related conditions.

Abstract: Methods and formulations are presented that provide for a) the oral absorption of GLP-1 peptides that bind surfactants; and b) long-term storage of formulations containing these peptides. For example, a GLP-1/DSS complex is administered orally instead of parenterally, which is much more convenient for, and facilitates compliance with diabetic patients and persons with other GLP-1 treated conditions.

Abstract: The invention provides individual tetragonal flat rod shaped or plate-like crystals of glucagon-like peptide-1 related molecules, processes for their preparation, compositions and methods of use. The crystal preparations exhibit extended time action in vivo and are useful for treating diabetes, obesity and related conditions.

Abstract: A reactor for aerating a fluid with a gas comprises a mixing tank (12) for the fluid and a centrally located vertical draft tube (13) submerged in the fluid to divide the mixing tank (12) into an inner chamber (21) and an outer chamber (23). The reactor further comprises a motor driven axial flow impeller (14) located in the draft tube (13) for circulating fluid downwardly through the inner chamber (21) and upwardly through the outer chamber (23). The reactor further comprises an external circuit for withdrawing a portion of the fluid from the mixing tank (12), aerating the fluid, and returning the aerated fluid to the mixing tank (12). The aerator is in the form of a venturi device (17).

Abstract: Methods and formulations are presented that provide for a) the oral absorption of GLP-1 peptides that bind surfactants; and b) long-term storage of formulations containing these peptides. For example, a GLP-1/DSS complex is administered orally instead of parenterally, which is much more convenient for, and facilitates compliance with diabetic patients and persons with other GLP-1 treated conditions.

Abstract: The invention provides individual tetragonal flat rod shaped or plate-like crystals of glucagon-like peptide-1 related molecules, processes for their preparation, compositions and methods of use. The crystal preparations exhibit extended time action in vivo and are useful for treating diabetes, obesity and related conditions.

Abstract: A reactor for aerating a fluid with a gas comprises a mixing tank (12) for the fluid and a centrally located vertical draft tube (13) submerged in the fluid to divide the mixing tank (12) into an inner chamber (21) and an outer chamber (23). The reactor further comprises a motor driven axial flow impeller (14) located in the draft tube (13) for circulating fluid downwardly through the inner chamber (21) and upwardly through the outer chamber (23). The reactor further comprises an external circuit for withdrawing a portion of the fluid from the mixing tank (12), aerating the fluid, and returning the aerated fluid to the mixing tank (12). The aerator is in the form of a venturi device (17).

Abstract: The invention provides extended-action GLP-1 based peptides and compositions that are useful for treating diabetes and minimize the risk of hypoglycemia.

Abstract: The present invention provides novel compounds, which comprise an obesity protein analog complexed with a divalent metal cation, pharmaceutical formulations thereof, and methods of using such compounds for treating obesity, and disorders associated with obesity such as diabetes, cardiovascular disease and cancer.

Abstract: The invention provides individual tetragonal flat rod shaped or plate-like crystals of glucagon-like peptide-1 related molecules, processes for their preparation, compositions and methods of use. The crystal preparations exhibit extended time action in vivo and are useful for treating diabetes, obesity and related conditions.