Patents by Inventor Arthur Krieg
Arthur Krieg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210030783Abstract: Provided are compositions and methods for treating cancer using administration of certain volumes of CpG oligonucleotides (CpG ODN) and, optionally, administration of a checkpoint inhibitor such as an anti-PD-1 antibody, an anti-PD-L1 antibody, and/or an anti-CTLA-4 antibody. In preferred embodiments, the CpG ODN are selected based on their propensity to induce high amounts of interferon alpha (IFN-a) and T-cell activation relative to interleukin-10 (IL-10) and B-cell activation. In certain embodiments, the methods further include pretreatment with radiotherapy, to potentiate the combination immunotherapy.Type: ApplicationFiled: February 12, 2019Publication date: February 4, 2021Inventors: Arthur Krieg, Aaron Morris, David Mauro, George Weiner, Mohammed Milhem
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Publication number: 20200281953Abstract: Provided are methods for treating cancer using local administration of certain CpG oligonucleotides (CpG ODN) and systemic administration of a checkpoint inhibitor such as an anti-PD-1 antibody, an anti-PD-L1 antibody, and/or an anti-CLA-4 antibody. In preferred embodiments, the CpG ODN are selected based on their propensity to induce high amounts of interferon alpha (IFN-?) and T-cell activation relative to interleukin-10 (IL-10) and B-cell activation. In certain embodiments, the methods further include pretreatment with radiotherapy, to potentiate the combination immunotherapy.Type: ApplicationFiled: May 5, 2020Publication date: September 10, 2020Inventor: Arthur Krieg
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Publication number: 20080045473Abstract: The present invention relates generally to immunostimulatory nucleic acids, compositions thereof and methods of using the immunostimulatory nucleic acids. In particular the invention relates to palindrome-containing immunostimulatory nucleic acids and the use of these nucleic acids in treating disease.Type: ApplicationFiled: February 15, 2007Publication date: February 21, 2008Applicants: Coley Pharmaceutical GmbH, Coley Pharmaceutical Group, Inc.Inventors: Eugen Uhlmann, Jorg Vollmer, Arthur Krieg, Ulrike Samulowitz, Bernhard Noll
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Publication number: 20080031936Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.Type: ApplicationFiled: November 10, 2006Publication date: February 7, 2008Applicants: University of Iowa Research Foundation, Coley Pharmaceutical Group, Inc., U.S.A., as represented by the Secretary, Dept. of Health and Human ServicesInventors: Arthur Krieg, Joel Kline, Dennis Klinman, Alfred Steinberg
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Publication number: 20080026011Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.Type: ApplicationFiled: June 5, 2007Publication date: January 31, 2008Applicants: University of Iowa Research Foundation, The US, as represented by the Department of Health and Human ServicesInventors: Arthur Krieg, Joel Kline, Dennis Klinman
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Publication number: 20080009455Abstract: The invention relates to a class of short CpG immunostimulatory oligonucleotides that are useful for stimulating an immune response. Preferably the short oligonucleotides are soft or semi-soft oligonucleotides.Type: ApplicationFiled: February 24, 2006Publication date: January 10, 2008Applicants: Coley Pharmaceutical Group, Inc., Coley Pharmaceutical GmbHInventors: Arthur Krieg, Ulrike Samulowitz, Jorg Vollmer
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Publication number: 20070224210Abstract: The invention relates to a class of soft or semi-soft CpG immunostimulatory oligonucleotides that are useful for stimulating an immune response.Type: ApplicationFiled: October 4, 2006Publication date: September 27, 2007Applicants: Coley Pharmaceutical Group, Inc., Coley Pharmaceutical GmbHInventors: Arthur Krieg, Grayson Lipford, Ulrike Samulowitz, Jorg Vollmer, Eugen Uhlmann, Marion Jurk, Robert Rankin
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Publication number: 20070202128Abstract: Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are initiated by unthylated CpG dinucleotides in a subject comprising administering to the subject oligonucleotides that do not contain unmethylated CpG sequences (i.e. methylated CpG sequences or no CpG sequence) to outcompete unmethylated CpG nucleic acids for binding. Further disclosed are methylated CpG containing dinucleotides for use antisense therapies or as in vivo hybridization probes, and immunoinhibitory oligonucleotides for use as antiviral therapeutics.Type: ApplicationFiled: December 22, 2006Publication date: August 30, 2007Applicants: Coley Pharmaceutical Group, Inc, United States of America as represented by the Secretary, Department of Health & Human Services, University of Iowa Research FoundationInventors: Arthur Krieg, Dennis Klinman, Alfred Steinberg
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Publication number: 20070078104Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.Type: ApplicationFiled: September 22, 2006Publication date: April 5, 2007Applicants: University of Iowa Research Foundation, Coley Pharmaceutical Group, Inc.Inventors: Arthur Krieg, Joel Kline
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Publication number: 20070066554Abstract: The invention relates to immunostimulatory nucleic acid compositions and methods of using the compositions. The T-rich nucleic acids contain poly T sequences and/or have greater than 25% T nucleotide residues. The TG nucleic acids have TG dinucleotides. The C-rich nucleic acids have at least one poly-C region and/ore greater than 50% c nucleotides. These immunostimulatory nucleic acids function in a similar manner to nucleic acids containing CpG motifs. The invention also encompasses preferred CpG nucleic acids.Type: ApplicationFiled: August 18, 2006Publication date: March 22, 2007Applicants: Coley Pharmaceutical GmbH, University of Iowa Research FoundationInventors: Arthur Krieg, Christian Schetter, Jorg Vollmer
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Publication number: 20070065467Abstract: The present invention relates generally to methods and products for activating dendritic cells. In particular, the invention relates to oligonucleotides which have a specific sequence including at least one unmethylated CpG dinucleotide which are useful for activating dendritic cells. The methods are useful for in vitro, ex-vivo, and in vivo methods such as cancer immunotherapeutics, treatment of infectious disease and treatment of allergic disease.Type: ApplicationFiled: August 11, 2006Publication date: March 22, 2007Applicant: University of Iowa Research FoundationInventors: Arthur Krieg, Gunther Hartmann
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Publication number: 20070066553Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.Type: ApplicationFiled: August 11, 2006Publication date: March 22, 2007Applicants: University of Iowa Research Foundation, Coley Pharmaceutical Group, Inc., United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Arthur Krieg, Joel Kline, Dennis Klinman, Alfred Steinberg
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Publication number: 20070009482Abstract: Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are initiated by unthylated CpG dinucleotides in a subject comprising administering to the subject oligonucleotides that do not contain unmethylated CpG sequences (i.e. methylated CpG sequences or no CpG sequence) to outcompete unmethylated CpG nucleic acids for binding. Further disclosed are methylated CpG containing dinucleotides for use antisense therapies or as in vivo hybridization probes, and immunoinhibitory oligonucleotides for use as antiviral therapeutics.Type: ApplicationFiled: May 11, 2005Publication date: January 11, 2007Applicants: University of Iowa Research Foundation, Coley Pharmaceutical Group, Inc., United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Arthur Krieg, Dennis Klinman, Alfred Steinberg
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Publication number: 20070010470Abstract: Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are initiated by unthylated CpG dinucleotides in a subject comprising administering to the subject oligonucleotides that do not contain unmethylated CpG sequences (i.e. methylated CpG sequences or no CpG sequence) to outcompete unmethylated CpG nucleic acids for binding. Further disclosed are methylated CpG containing dinucleotides for use antisense therapies or as in vivo hybridization probes, and immunoinhibitory oligonucleotides for use as antiviral therapeutics.Type: ApplicationFiled: May 11, 2005Publication date: January 11, 2007Applicants: University of Iowa Research Foundation, Coley Pharmaceutical Group, Inc., United States of America, as represented by the Secretary, Department of Health & Human ServicesInventors: Arthur Krieg, Dennis Klinman, Alfred Steinberg
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Publication number: 20060286070Abstract: Methods and compositions are provided for extending the clinical utility of IFN-? in the treatment of a variety of viral and proliferative disorders. Among other aspects, the invention provides methods which increase the efficacy of IFN-? treatment and reduce IFN-? treatment-related side effects. In addition, methods are provided for supporting the survival and for activating natural interferon producing cells (IPCs) in vitro without exogenous IL-3 or GM-CSF. The invention is based on the discovery that certain CpG and non-CpG ISNAs promote survival and stimulation of IPCs.Type: ApplicationFiled: July 8, 2005Publication date: December 21, 2006Applicants: Coley Pharmaceutical GmbH, Coley Pharmaceutical Group, Inc., University of Iowa Research FoundationInventors: Gunther Hartmann, Robert Bratzler, Arthur Krieg
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Publication number: 20060241076Abstract: The invention provides immunostimulatory compositions and methods for their use. In particular, the immunostimulatory compositions of the invention include RNA-like polymers that incorporate an immunostimulatory sequence motif and at least one chemical modification to confer improved stability against nuclease degradation and improved activity. Specific modifications involving phosphate linkages, nucleotide analogs, and combinations thereof are provided. Compositions of the invention optionally include an antigen and can be used to stimulate an immune response. Also provided are compositions and methods useful for treating a subject having an infection, a cancer, an allergic condition, or asthma. Modified oligoribonucleotide analogs of the invention are believed to stimulate Toll-like receptors TLR7 and TLR8.Type: ApplicationFiled: April 26, 2006Publication date: October 26, 2006Applicants: Coley Pharmaceutical GmbH, Coley Pharmaceutical Group, Inc.Inventors: Eugen Uhlmann, Arthur Krieg, Grayson Lipford
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Publication number: 20060229271Abstract: The invention relates to methods of treating infectious disease exacerbated asthma. In particular, the methods are useful for treating viral exacerbated asthma using CpG oligonucleotides.Type: ApplicationFiled: April 10, 2006Publication date: October 12, 2006Applicants: Coley Pharmaceutical Group, Inc., Sanofi-Aventis U.S.P. LLCInventors: Arthur Krieg, George De Sanctis, Stephen Underwood, Raymond Jupp, John Schmidt
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Publication number: 20060211644Abstract: The invention relates to a class of short CpG immunostimulatory oligonucleotides that are useful for stimulating an immune response. Preferably the short oligonucleotides are soft or semi-soft oligonucleotides.Type: ApplicationFiled: February 24, 2006Publication date: September 21, 2006Applicants: Coley Pharmaceutical Group, Inc., Coley Pharmaceutical GmbHInventors: Arthur Krieg, Ulrike Samulowitz, Jorg Vollmer
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Publication number: 20060188913Abstract: The invention involves administration of an imidazoquinoline agent in combination with another therapeutic agent. The combination of drugs may be administered in synergistic amounts or in various dosages or at various time schedules. The invention also relates to kits and compositions concerning the combination of drugs. The combinations can be used to enhance ADCC, stimulate immune responses and/or patient and treat certain disorders.Type: ApplicationFiled: March 3, 2006Publication date: August 24, 2006Applicants: University of Iowa Research Foundation, Coley Pharmaceutical GmbH, Coley Pharmaceutical Group, Inc.Inventors: Arthur Krieg, Christian Schetter, Robert Bratzler, Jorg Vollmer, Marion Jurk, Stefan Bauer
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Publication number: 20060140875Abstract: The invention relates to specific C-Class semi-soft CpG immunostimulatory oligonucleotides that are useful for stimulating an immune response. In particular the oligonucleotides are useful for treating allergy, such as allergic rhinitis and asthma, cancer and infectious disease, such as hepatitis B and hepatitis C.Type: ApplicationFiled: October 20, 2005Publication date: June 29, 2006Applicants: Coley Pharmaceutical Group, Inc., Coley Pharmaceutical GmbHInventors: Arthur Krieg, Ulrike Samulowitz, Jorg Vollmer, Eugen Uhlmann