Patents by Inventor Arthur L. Kruckeberg

Arthur L. Kruckeberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Means and methods for regulating gene expression
    Patent number: 7794977
    Abstract: The invention relates to means and methods for regulating gene expression and production of proteinaceous molecules. The invention provides a method for producing a proteinaceous molecule in a cell comprising selecting a cell for its suitability for producing the proteinaceous molecule, providing a nucleic acid encoding the proteinaceous molecule with a nucleic acid comprising a STAR (STabilizing Anti-Repression) sequence, expressing the resulting nucleic acid in the cell and collecting the proteinaceous molecule. Providing at least one STAR sequence to a nucleic acid encoding a proteinaceous molecule will enhance production (yield) of the proteinaceous molecule by a host cell, increase the proportion of host cells with acceptable expression levels, and/or increase stability of a gene expression level.
    Type: Grant
    Filed: July 31, 2007
    Date of Patent: September 14, 2010
    Assignee: Chromagenics B.V.
    Inventors: Arie P. Otte, Arthur L. Kruckeberg, David P. E. Satijn
  • Nucleic acid sequences having gene transcription regulatory qualities
    Patent number: 7749733
    Abstract: The invention is concerned with the systematic elucidation and identification of regulatory sequences. The invention provides among others screenings and detection methods with which regulatory sequences can be identified. The invention further provides regulatory sequences and use thereof in various fields such as, but not limited to, protein production, diagnostics, transgenic plants and animals, and the therapeutic field.
    Type: Grant
    Filed: October 13, 2006
    Date of Patent: July 6, 2010
    Assignee: Chromagenics B.V.
    Inventors: Arie P. Otte, Arthur L. Kruckeberg
  • Nucleic acid sequences having gene transcription regulatory qualities
    Patent number: 7736869
    Abstract: The invention is concerned with the systematic elucidation and identification of regulatory sequences. The invention provides among others screenings and detection methods with which regulatory sequences can be identified. The invention further provides regulatory sequences and use thereof in various fields such as, but not limited to, protein production, diagnostics, transgenic plants and animals, and the therapeutic field.
    Type: Grant
    Filed: October 13, 2006
    Date of Patent: June 15, 2010
    Assignee: Chromagenics B.V.
    Inventors: Arie P. Otte, Arthur L. Kruckeberg
  • Nucleic acid sequences having gene transcription regulatory qualities
    Patent number: 7736870
    Abstract: The invention is concerned with the systematic elucidation and identification of regulatory sequences. The invention provides among others screenings and detection methods with which regulatory sequences can be identified. The invention further provides regulatory sequences and use thereof in various fields such as, but not limited to, protein production, diagnostics, transgenic plants and animals, and the therapeutic field.
    Type: Grant
    Filed: October 13, 2006
    Date of Patent: June 15, 2010
    Assignee: Chromagenics B.V.
    Inventors: Arie P. Otte, Arthur L. Kruckeberg
  • Nucleic acid sequences having gene transcription regulatory qualities
    Patent number: 7736868
    Abstract: The invention is concerned with the systematic elucidation and identification of regulatory sequences. The invention provides among others screenings and detection methods with which regulatory sequences can be identified. The invention further provides regulatory sequences and use thereof in various fields such as, but not limited to, protein production, diagnostics, transgenic plants and animals, and the therapeutic field.
    Type: Grant
    Filed: October 13, 2006
    Date of Patent: June 15, 2010
    Assignee: Chromagenics B.V.
    Inventors: Arie P. Otte, Arthur L. Kruckeberg
  • Nucleic acid sequences having gene transcription regulatory qualities
    Patent number: 7662591
    Abstract: The invention is concerned with the systematic elucidation and identification of regulatory sequences. The invention provides among others screenings and detection methods with which regulatory sequences can be identified. The invention further provides regulatory sequences and use thereof in various fields such as, but not limited to, protein production, diagnostics, transgenic plants and animals, and the therapeutic field.
    Type: Grant
    Filed: October 13, 2006
    Date of Patent: February 16, 2010
    Assignee: Chromagenics B.V.
    Inventors: Arie P. Otte, Arthur L. Kruckeberg
  • Nucleic acid sequences having gene transcription regulatory qualities
    Patent number: 7659094
    Abstract: The invention is concerned with the systematic elucidation and identification of regulatory sequences. The invention provides among others screenings and detection methods with which regulatory sequences can be identified. The invention further provides regulatory sequences and use thereof in various fields such as, but not limited to, protein production, diagnostics, transgenic plants and animals, and the therapeutic field.
    Type: Grant
    Filed: October 13, 2006
    Date of Patent: February 9, 2010
    Assignee: Chromagenics B.V.
    Inventors: Arie P. Otte, Arthur L. Kruckeberg
  • Nucleic acid sequences having gene transcription regulatory qualities
    Patent number: 7655441
    Abstract: The invention is concerned with the systematic elucidation and identification of regulatory sequences. The invention provides among others screenings and detection methods with which regulatory sequences can be identified. The invention further provides regulatory sequences and use thereof in various fields such as, but not limited to, protein production, diagnostics, transgenic plants and animals, and the therapeutic field.
    Type: Grant
    Filed: October 13, 2006
    Date of Patent: February 2, 2010
    Assignee: Chromagenics B.V.
    Inventors: Arie P. Otte, Arthur L. Kruckeberg
  • Means and methods for regulating gene expression
    Publication number: 20080206813
    Abstract: Described are means and methods for regulating gene expression and production of proteinaceous molecules. Described are methods for producing a proteinaceous molecule in a cell comprising selecting a cell for its suitability for producing the proteinaceous molecule, providing a nucleic acid encoding the proteinaceous molecule with a nucleic acid comprising a STAR (STabilizing Anti-Repression) sequence, expressing the resulting nucleic acid in the cell and collecting the proteinaceous molecule. Providing at least one STAR sequence to a nucleic acid encoding a proteinaceous molecule enhances production (yield) of the proteinaceous molecule by the host cell, increases the proportion of host cells with acceptable expression levels, and/or increases the stability of a gene expression level.
    Type: Application
    Filed: October 26, 2007
    Publication date: August 28, 2008
    Applicant: ChromaGenics B.V.
    Inventors: Arie P. Otte, Arthur L. Kruckeberg, David P. E. Satijn
  • Means and methods for regulating gene expression
    Publication number: 20080131930
    Abstract: The invention relates to means and methods for regulating gene expression and production of proteinaceous molecules. The invention provides a method for producing a proteinaceous molecule in a cell comprising selecting a cell for its suitability for producing the proteinaceous molecule, providing a nucleic acid encoding the proteinaceous molecule with a nucleic acid comprising a STAR (STabilizing Anti-Repression) sequence, expressing the resulting nucleic acid in the cell and collecting the proteinaceous molecule. Providing at least one STAR sequence to a nucleic acid encoding a proteinaceous molecule will enhance production (yield) of the proteinaceous molecule by a host cell, increase the proportion of host cells with acceptable expression levels, and/or increase stability of a gene expression level.
    Type: Application
    Filed: July 31, 2007
    Publication date: June 5, 2008
    Applicant: ChromaGenics B.V.
    Inventors: Arie P. Otte, Arthur L. Kruckeberg, David P.E. Satijn
  • Means and methods for regulating gene expression
    Patent number: 7267965
    Abstract: The invention relates to means and methods for regulating gene expression and production of proteinaceous molecules. The invention provides a method for producing a proteinaceous molecule in a cell comprising selecting a cell for its suitability for producing the proteinaceous molecule, providing a nucleic acid encoding the proteinaceous molecule with a nucleic acid comprising a STAR (STabilizing Anti-Repression) sequence, expressing the resulting nucleic acid in the cell and collecting the proteinaceous molecule. Providing at least one STAR sequence to a nucleic acid encoding a proteinaceous molecule will enhance production (yield) of the proteinaceous molecule by a host cell, increase the proportion of host cells with acceptable expression levels, and/or increase stability of a gene expression level.
    Type: Grant
    Filed: December 14, 2004
    Date of Patent: September 11, 2007
    Assignee: Chromagenics B.V.
    Inventors: Arie P. Otte, Arthur L. Kruckeberg, David P. E. Satijn