Abstract: Provided herein are methods for treating sickle cell disease comprising administering Compound (I), a modulator of hemoglobin, according to certain dosing regimens.

Abstract: Provided herein are methods of treating a patient infected with a coronavirus and having a baseline level of CRP below 150 mg/L, comprising administering to the patient a compound of formula 1: or a pharmaceutically-acceptable salt thereof.

Abstract: Methods of safely administrating a gut-selective JAK3 inhibitor by oral administration are described. Also described are methods for providing clinically proven safe treatment of gastrointestinal inflammatory diseases, such as celiac disease, by oral administration of a gut-selective JAK3 inhibitor.

Abstract: Methods of safely administrating a gut-selective JAK3 inhibitor by oral administration are described. Also described are methods for providing clinically proven safe treatment of gastrointestinal inflammatory diseases, such as celiac disease, by oral administration of a gut-selective JAK3 inhibitor.

Abstract: Provided herein are methods of treating a patient infected with a coronavirus comprising administering to the patient a compound of formula 1: or a pharmaceutically-acceptable salt thereof.

Abstract: Doses and methods for administering telavancin or a pharmaceutically-acceptable salt thereof to a human patient having an infection caused by Staphylococcus aureus, such as bacteremia, pneumonia, endocarditis, osteomyelitis, a prosthetic joint infection or a complicated skin and skin structure infection, are disclosed. Also disclosed are methods for treating an infection caused by Staphylococcus aureus in a human patient using telavancin or a pharmaceutically-acceptable salt thereof. The dose of telavancin administered to the patient is determined, in part, by the weight and creatinine clearance of the patient.

Abstract: A workflow management system provides a GUI Configurability tool that allows an end user to configure the system's workflow screens, workflow logic and data fields without the need to rewrite any programs. The system allows each workflow screen to represent and assist each individual task within a business process that may be defined and illustrated by a flowchart. The workflow screens work in conjunction with workflow logic to create an accurate one-to-one mapping of the individual tasks and decision logic within a business process flowchart. The system provides published interfaces that allow the use of third party hardware and software within workflows. The system also provides published interfaces to integrate extensible code that perform custom functions within the system.

Abstract: Doses and methods for administering telavancin or a pharmaceutically-acceptable salt thereof to a human patient having an infection caused by Staphylococcus aureus, such as bacteremia, pneumonia, endocarditis, osteomyelitis, a prosthetic joint infection or a complicated skin and skin structure infection, are disclosed. Also disclosed are methods for treating an infection caused by Staphylococcus aureus in a human patient using telavancin or a pharmaceutically-acceptable salt thereof. The dose of telavancin administered to the patient is determined, in part, by the weight and creatinine clearance of the patient.

Abstract: A workflow management system provides a graphical user interface (GUI) tool that allows a user to create and/or edit workflow logic without requiring the re-writing and recompiling of the application software, and without interrupting the operability of the application software at any time. The GUI tool allows the user to simultaneously view and create and/or edit the corresponding application screen where the workflow logic is applied in the application software, while the user creates and/or edits the workflow logic. The user creates and/or edits the workflow logic by selectively combining the available parameters that are provided in spoken language syntax by a context sensitive menu. The workflow logic statements are made available for the application software to call at the appropriate times. The GUI tool works in conjunction with a dynamically configurable database.

Abstract: A workflow management system provides a GUI Configurability tool that allows an end user to configure the system's workflow screens, workflow logic and data fields without the need to rewrite any programs. The system allows each workflow screen to represent and assist each individual task within a business process that may be defined and illustrated by a flowchart. The workflow screens work in conjunction with workflow logic to create an accurate one-to-one mapping of the individual tasks and decision logic within a business process flowchart. The system provides published interfaces that allow the use of third party hardware and software within workflows. The system also provides published interfaces to integrate extensible code that perform custom functions within the system.

Abstract: Doses and methods for administering telavancin or a pharmaceutically-acceptable salt thereof to a human patient having an infection caused by Staphylococcus aureus, such as bacteremia, pneumonia, endocarditis, osteomyelitis, a prosthetic joint infection or a complicated skin and skin structure infection, are disclosed. Also disclosed are methods for treating an infection caused by Staphylococcus aureus in a human patient using telavancin or a pharmaceutically-acceptable salt thereof. The dose of telavancin administered to the patient is determined, in part, by the weight and creatinine clearance of the patient.

Abstract: A computer-implemented method for a dynamic computer-based appointment slot booking comprises a plurality of steps wherein appointment slots (and their attributes) in a locked database are entangled via one or more virtual umbilical cords in a manner analogous to the formation of quantum systems, in such a way, the entangled appointment slots comprise a system carrying a character of “wholeness” and wherein the database so formed is unlocked (made available for new appointment selection and entry), said act of booking a new appointment i) creates consequences to the entangled appointment slots (and their attributes) ii) reflects the “wholeness” of the quantum system.

Abstract: A workflow management system provides a graphical user interface (GUI) tool that allows a user to create and/or edit workflow logic without requiring the re-writing and recompiling of the application software, and without interrupting the operability of the application software at any time. The GUI tool allows the user to simultaneously view and create and/or edit the corresponding application screen where the workflow logic is applied in the application software, while the user creates and/or edits the workflow logic. The user creates and/or edits the workflow logic by selectively combining the available parameters that are provided in spoken language syntax by a context sensitive menu. The workflow logic statements are made available for the application software to call at the appropriate times. The GUI tool works in conjunction with a dynamically configurable database.

Abstract: A computer-implemented method for a dynamic computer-based appointment slot booking comprises a plurality of steps wherein appointment slots (and their attributes) in a locked database are entangled via one or more virtual umbilical cords in a manner analogous to the formation of quantum systems, in such a way, the entangled appointment slots comprise a system carrying a character of “wholeness” and wherein the database so formed is unlocked (made available for new appointment selection and entry), said act of booking a new appointment i) creates consequences to the entangled appointment slots (and their attributes) ii) reflects the “wholeness” of the quantum system.

Abstract: A workflow management system provides a GUI Configurability tool that allows an end user to configure the system's workflow screens, workflow logic and data fields without the need to rewrite any programs. The system allows each workflow screen to represent and assist each individual task within a business process that may be defined and illustrated by a flowchart. The workflow screens work in conjunction with workflow logic to create an accurate one-to-one mapping of the individual tasks and decision logic within a business process flowchart. The system provides published interfaces that allow the use of third party hardware and software within workflows. The system also provides published interfaces to integrate extensible code that perform custom functions within the system.

Abstract: A workflow management system provides a GUI Configurability tool that allows an end user to configure the system's workflow screens, workflow logic and data fields without the need to rewrite any programs. The system allows each workflow screen to represent and assist each individual task within a business process that may be defined and illustrated by a flowchart. The workflow screens work in conjunction with workflow logic to create an accurate one-to-one mapping of the individual tasks and decision logic within a business process flowchart. The system provides published interfaces that allow the use of third party hardware and software within workflows. The system also provides published interfaces to integrate extensible code that perform custom functions within the system.

Abstract: The invention encompasses novel computer models of atherosclerosis and systems for predicting development and progression of atherosclerosis as well as associated cardiovascular risk. In particular, the computer model of atherosclerosis comprises a) a cholesterol metabolism module; b) an atherogenesis module; and c) a plaque stability module. The computer model optionally further comprises a cardiovascular risk module.

Abstract: The invention provides a souvenir travel guidebook with an ability to have holding members on the same page of a printed material to be utilized for displaying traditional photographs, for storing mounted or unmounted slide transparencies of varying sizes, picture/photo CD's, floppy disks, postcards, tickets and other travel memorabilia. It is a new method to display and organize the above items in such a way that the souvenir travel guidebook itself is also the photo album.