Patents by Inventor Arthur M. MERCURIO

Arthur M. MERCURIO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of treating VEGF/VEGFR resistant prostate, renal, or colorectal cancers using combination therapies
    Patent number: 11920135
    Abstract: Methods and compositions for treating cancer, e.g., prostate cancer, using a combination of P-Rex1 or Rac1 inhibitors and VEGF/VEGFR-targeted therapy.
    Type: Grant
    Filed: February 4, 2021
    Date of Patent: March 5, 2024
    Assignee: University of Massachusetts
    Inventors: Hira Lal Goel, Arthur M. Mercurio
  • Reducing Prominin2-Mediated Resistance to Ferroptotic Cell Death
    Publication number: 20210380988
    Abstract: Compositions and methods for inducing tumor cell death by inhibiting prominin2 (PROM2) or heat shock factor protein 1 (HSF1), optionally in combination with an agent that promotes ferroptosis, preferably an inhibitor of glutathione peroxidase 4 (GPX4), e.g., to trigger ferroptosis in the tumor cells.
    Type: Application
    Filed: May 13, 2021
    Publication date: December 9, 2021
    Inventors: Arthur M. Mercurio, Caitlin Westberg Brown
  • METHODS OF TREATING VEGF/VEGFR RESISTANT PROSTATE CANCER USING COMBINATION THERAPY
    Publication number: 20210163954
    Abstract: Methods and compositions for treating cancer, e.g., prostate cancer, using a combination of P-Rex1 or Rac1 inhibitors and VEGF/VEGFR-targeted therapy.
    Type: Application
    Filed: February 4, 2021
    Publication date: June 3, 2021
    Inventors: Hira Lal Goel, Arthur M. Mercurio
  • Method of treating VEGF/VEGFR resistant prostate cancer by combining the therapy with RAC1 inhibitors
    Patent number: 10947537
    Abstract: Methods and compositions for treating cancer, e.g., prostate cancer, using a combination of P-Rex1 or Rac1 inhibitors and VEGF/VEGFR-targeted therapy.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: March 16, 2021
    Assignee: University of Massachusetts
    Inventors: Hira Lal Goel, Arthur M. Mercurio
  • Combination Therapy
    Publication number: 20190040396
    Abstract: Methods and compositions for treating cancer, e.g., prostate cancer, using a combination of P-Rex1 or Rac1 inhibitors and VEGF/VEGFR-targeted therapy.
    Type: Application
    Filed: February 16, 2017
    Publication date: February 7, 2019
    Inventors: Hira Lal GOEL, Arthur M. MERCURIO