Patents by Inventor Arthur M. P. Doweyko

Arthur M. P. Doweyko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CYCLIC PROTEIN TYROSINE KINASE INHIBITORS
    Publication number: 20190210986
    Abstract: Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders.
    Type: Application
    Filed: March 18, 2019
    Publication date: July 11, 2019
    Inventors: Jagabandhu Das, Ramesh Padmanabha, Ping Chen, Derek J. Norris, Arthur M.P. Doweyko, Joel C. Barrish, John Wityak
  • CYCLIC PROTEIN TYROSINE KINASE INHIBITORS
    Publication number: 20180016247
    Abstract: Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders.
    Type: Application
    Filed: September 27, 2017
    Publication date: January 18, 2018
    Inventors: Jagabandhu Das, Ramesh Padmanabha, Ping Chen, Derek J. Norris, Arthur M.P. Doweyko, Joel C. Barrish, John Wityak
  • CYCLIC PROTEIN TYROSINE KINASE INHIBITORS
    Publication number: 20160264537
    Abstract: Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders.
    Type: Application
    Filed: May 25, 2016
    Publication date: September 15, 2016
    Inventors: Jagabandhu Das, Ramesh Padmanabha, Ping Chen, Derek Norris, Arthur M.P. Doweyko, Joel C. Barrish, John Wityak
  • Cyclic protein tyrosine kinase inhibitors
    Patent number: 9382219
    Abstract: Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders.
    Type: Grant
    Filed: February 12, 2015
    Date of Patent: July 5, 2016
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jagabandhu Das, Ramesh Padmanabha, Ping Chen, Derek Norris, Arthur M. P. Doweyko, Joel C. Barrish, John Wityak
  • CYCLIC PROTEIN TYROSINE KINASE INHIBITORS
    Publication number: 20150158830
    Abstract: Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders.
    Type: Application
    Filed: February 12, 2015
    Publication date: June 11, 2015
    Inventors: Jagabandhu Das, Ramesh Padmanabha, Ping Chen, Derek Norris, Arthur M.P. Doweyko, Joel C. Barrish, John Wityak
  • Cyclic protein tyrosine kinase inhibitors
    Patent number: 8993567
    Abstract: Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders.
    Type: Grant
    Filed: March 27, 2014
    Date of Patent: March 31, 2015
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jagabandhu Das, Ramesh Padmanabha, Ping Chen, Derek Norris, Arthur M. P. Doweyko, Joel C. Barrish, John Wityak
  • CYCLIC PROTEIN TYROSINE KINASE INHIBITORS
    Publication number: 20140206691
    Abstract: Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders.
    Type: Application
    Filed: March 27, 2014
    Publication date: July 24, 2014
    Inventors: Jagabandhu Das, Ramesh Padmanabha, Ping Chen, Derek Norris, Arthur M.P. Doweyko, Joel C. Barrish, John Wityak
  • Cyclic protein tyrosine kinase inhibitors
    Patent number: 8716323
    Abstract: Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders.
    Type: Grant
    Filed: November 10, 2005
    Date of Patent: May 6, 2014
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jagabandhu Das, Ramesh Padmanabha, Ping Chen, Derek J. Norris, Arthur M. P. Doweyko, Joel C. Barrish, John Wityak
  • Thyroid receptor ligands
    Patent number: 8263659
    Abstract: A method is provided for preventing, inhibiting or treating diseases or disorders associated with metabolism dysfunction or which are dependent upon the expression of a T3 regulated gene, wherein a compound as described in the general formula I below is administered in a therapeutically effective amount:
    Type: Grant
    Filed: May 21, 2009
    Date of Patent: September 11, 2012
    Assignee: Bristol-Myers Squibb Company
    Inventors: Denis E. Ryono, Jon J. Hangeland, Todd J. Friends, Tamara Dejneka, Pratik Devasthale, Yolanda V. Caringal, Minsheng Zhang, Arthur M. P. Doweyko, Johan Malm, Andrei Sanin
  • THYROID RECEPTOR LIGANDS
    Publication number: 20100298276
    Abstract: Thyroid receptor ligands are provided which have the general formula I wherein: R1 is R2 and R3 are the same or different and are hydrogen, halogen, alkyl of 1 to 4 carbons or cycloalkyl of 3 to 5 carbons, provided that at least one of R2 and R3 is other than hydrogen; R4 is R5 and R6 are the same or different and are selected from hydrogen, aryl, heteroaryl, alkyl, cycloalkyl, aralkyl or heteroaralkyl.
    Type: Application
    Filed: May 21, 2009
    Publication date: November 25, 2010
    Inventors: Denis E. Ryono, Jon J. Hangeland, Todd J. Friends, Tamara Dejneka, Pratik Devasthale, Yolanda V. Caringal, Minsheng Zhang, Arthur M.P. Doweyko, Johan Malm, Andrei Sanin
  • METHODS OF INHIBITING QUIESCENT TUMOR PROLIFERATION
    Publication number: 20100233172
    Abstract: Improved compositions and methods are disclosed which are useful of the treatment and prevention of proliferative disorders, and methods of screening to identify compounds for such treatments.
    Type: Application
    Filed: December 16, 2009
    Publication date: September 16, 2010
    Inventors: Roberto Weinmann, Rameh Hafezi, Arthur M.P. Doweyko, Ashok Ramesh Dongre, Deborah L. Roussell, Robert F. Carney
  • Thyroid receptor ligands
    Patent number: 7557143
    Abstract: Thyroid receptor ligands are provided which have the general formula I wherein: R1 is R2 and R3 are the same or different and are hydrogen, halogen, alkyl of 1 to 4 carbons or cycloalkyl of 3 to 5 carbons, provided that at least one of R2 and R3 is other than hydrogen; R4 is R5 and R6 are the same or different and are selected from hydrogen, aryl, heteroaryl, alkyl, cycloalkyl, aralkyl or heteroaralkyl.
    Type: Grant
    Filed: April 15, 2004
    Date of Patent: July 7, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Denis E. Ryono, Jon J. Hangeland, Todd J. Friends, Tamara Dejneka, Pratik Devasthale, Yolanda V. Caringal, Minsheng Zhang, Arthur M. P. Doweyko, Johan Malm, Andrei Sanin
  • Compositions and methods involving glucocorticoid receptor site II
    Patent number: 7442554
    Abstract: A binding site in nuclear hormone receptors is described and its structural coordinates are provided. The invention provides machine-readable data storage media comprising structure coordinates of Site II and computer systems comprising the machine-readable data storage media. The invention provides methods used in the design and identification of ligands of Site II and of modulators of nuclear hormone receptors. The invention provides ligands of Site II, modulators of NHRs, pharmaceutical compositions comprising modulators of NHRs, methods of modulating NHRs, and methods of treating diseases by administering modulators of an NHR. Also provided are methods of designing mutants, mutant NHRs, Site II binding assays, and models of Site II.
    Type: Grant
    Filed: July 17, 2003
    Date of Patent: October 28, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: Arthur M. P. Doweyko, Steven G. Nadler
  • Aryl ketone pyrrolo-triazine compounds useful as kinase inhibitors
    Patent number: 7314876
    Abstract: Compounds having the formula (I), and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are surprisingly advantageous as p38 kinase inhibitors, wherein R3 is hydrogen, methyl, perfluoromethyl, methoxy, halogen, cyano, NH2, or NH(CH3), preferably methyl; X is N or CH; and R1 through R6 are as described in the specification.
    Type: Grant
    Filed: April 22, 2003
    Date of Patent: January 1, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: Alaric J. Dyckman, Katerina Leftheris, John Hynes, Arthur M P. Doweyko
  • Thiazolyl inhibitors of Tec family tyrosine kinases
    Patent number: 7241781
    Abstract: Novel thiazolyl compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of Tec family tyrosine kinase-associated disorders such as cancer, immunologic disorders and allergic disorders.
    Type: Grant
    Filed: September 27, 2005
    Date of Patent: July 10, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: Joel C. Barrish, Jagabandhu Das, Steven B. Kanner, Chunjian Liu, Steven H. Spergel, John Wityak, Arthur M. P. Doweyko, Joseph A. Furch, III
  • Cyclic protein tyrosine kinase inhibitors
    Patent number: 7125875
    Abstract: Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders.
    Type: Grant
    Filed: March 24, 2003
    Date of Patent: October 24, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jagabandhu Das, Ramesh Padmanabha, Ping Chen, Derek J. Norris, Arthur M. P. Doweyko, Joel C. Barrish, John Wityak, Louis J. Lombardo, Francis Y. F. Lee
  • Cyclic protein tyrosine kinase inhibitors
    Patent number: 7091223
    Abstract: Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders.
    Type: Grant
    Filed: March 3, 2003
    Date of Patent: August 15, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jagabandhu Das, Ramesh Padmanabha, Ping Chen, Derek J. Norris, Arthur M. P. Doweyko, Joel C. Barrish, John Wityak
  • Thiazolyl inhibitors of Tec family tyrosine kinases
    Patent number: 7037926
    Abstract: Novel thiazolyl compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of Tec family tyrosine kinase-associated disorders such as cancer, immunologic disorders and allergic disorders.
    Type: Grant
    Filed: August 15, 2003
    Date of Patent: May 2, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Joel C. Barrish, Jagabandhu Das, Steven B. Kanner, Chunjian Liu, Steven H. Spergel, John Wityak, Arthur M. P. Doweyko, Joseph A. Furch, III
  • Cyclic protein tyrosine kinase inhibitors
    Patent number: 6979694
    Abstract: Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders.
    Type: Grant
    Filed: March 3, 2003
    Date of Patent: December 27, 2005
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jagabandhu Das, Ramesh Padmanabha, Ping Chen, Derek J. Norris, Arthur M. P. Doweyko, Joel C. Barrish, John Wityak
  • Thiazolyl inhibitors of Tec family tyrosine kinases
    Patent number: 6958336
    Abstract: Novel thiazolyl compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of Tec family tyrosine kinase-associated disorders such as cancer, immunologic disorders and allergic disorders.
    Type: Grant
    Filed: August 15, 2003
    Date of Patent: October 25, 2005
    Assignee: Bristol-Myers Squibb Company
    Inventors: Joel C. Barrish, Jagabandhu Das, Steven B. Kanner, Chunjian Liu, Steven H. Spergel, John Wityak, Arthur M. P. Doweyko, Joseph A. Furch, III