Patents by Inventor Arthur Patchett

Arthur Patchett has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted pyrollo-fused 6 membered heterocycles as angiotensin II antagonists
    Patent number: 5124335
    Abstract: Substituted pyrrolo-fused 6-membered heterocycles of structural formula: ##STR1## wherein A, B, C, and D are independently carbon atoms or nitrogen atoms are angiotensin II antagonists useful in the treatment of hypertension and congestive heart failure.
    Type: Grant
    Filed: January 30, 1991
    Date of Patent: June 23, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Arthur A. Patchett, Nathan B. Mantlo, William J. Greenlee
  • Immunosuppressive cyclosporin analogs with modified amino acids at position-8
    Patent number: 5122511
    Abstract: New immunosuppressive cyclosporin analogs are disclosed consisting of [dehydro-Ala].sup.8 cyclosporins and derived therefrom cyclosporins having a sulfur containing amino acid at position-8.
    Type: Grant
    Filed: February 27, 1990
    Date of Patent: June 16, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Arthur A. Patchett, David Taub, Robert T. Goegelman
  • Substituted imidazo-fused 6-membered heterocycles as angiotensin II antagonists
    Patent number: 5102880
    Abstract: Substituted Imidazo-fused 6-membered heterocycles of structural formula: ##STR1## wherein A, B, C, and D are independently carbon atoms or nitrogren atoms are angiotensin II antagonists useful in the treatment of hypertension and congestive heart failure.
    Type: Grant
    Filed: September 5, 1991
    Date of Patent: April 7, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Prasun K. Chakravarty, William J. Greenlee, Nathan B. Mantlo, Arthur A. Patchett, Thomas F. Walsh
  • Substituted pyrimidinones as angiotensin II antagonists
    Patent number: 5100897
    Abstract: Novel substituted pyrimidinones of formula (I) which are useful as angiotensin II antagonists, are disclosed.
    Type: Grant
    Filed: July 16, 1990
    Date of Patent: March 31, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Eric E. Allen, William J. Greenlee, Prasun K. Chakravarty, Arthur A. Patchett, Thomas F. Walsh
  • Certain phosphinic acid derivatives having antibacterial activity
    Patent number: 5099063
    Abstract: New 3-(1-aminoalkylphosphinyl)-(2-substituted)propionic acids are described which display antibacterial activity and potentiate carbapenem antibiotics.
    Type: Grant
    Filed: June 21, 1990
    Date of Patent: March 24, 1992
    Assignee: Merck & Co., Inc.
    Inventors: William H. Parsons, Arthur A. Patchett, William R. Schoen, Masao Taniguchi
  • Angiotensin II antagonists
    Patent number: 5064825
    Abstract: Novel substituted imidazo-fused 7-member ring heterocycles of the formulae (I) and (Ia), which are useful as angiotensin II antagonists, are disclosed.
    Type: Grant
    Filed: May 16, 1990
    Date of Patent: November 12, 1991
    Assignee: Merck & Co., Inc.
    Inventors: Prasun K. Chakravarty, William J. Greenlee, Nathan B. Mantlo, Arthur A. Patchett, William Schoen, Thomas F. Walsh
  • Phosphinic acid derivatives
    Patent number: 5061806
    Abstract: New phosphonic acid derivatives are described which display antibacterial activity.
    Type: Grant
    Filed: May 24, 1990
    Date of Patent: October 29, 1991
    Assignee: Merck & Co., Inc.
    Inventors: Yoshiharu Morita, Yasuo Hoshide, Haruyuki Chaki, Junko Takashima, Arthur A. Patchett
  • Renin inhibitors containing phenylalanyl-histidine replacements
    Patent number: 5039664
    Abstract: Peptides of the formula: ##STR1## which comprise novel elements replacing the Phe(8)-His(9) sequence in renin-inhibitory peptides based on substrate analogy, which inhibit the substrate-cleaving action of renin and have improved bioavailability; compositions containing these renin-inhibitory peptides, optionally with other antihypertensive agents; and methods of treating hypertension or congestive heart failure or of establishing renin as a causative factor in these problems which employ the novel peptides.
    Type: Grant
    Filed: March 8, 1989
    Date of Patent: August 13, 1991
    Assignee: Merck & Co., Inc.
    Inventors: Arthur A. Patchett, William H. Parsons, William J. Greenlee, Prasun K. Chakravarty
  • Renin inhibitors containing phenylalanyl-histidine replacements
    Patent number: 5037807
    Abstract: Peptides of the formula: ##STR1## which comprise novel elements replacing the Phe(8)-His(9) sequence in renin-inhibitory peptides based on substrate analogy, which inhibit the substrate-cleaving action of renin and have improved bioavailability; compositions containing these renin-inhibitory peptides, optionally with other antihypertensive agents; and methods of treating hypertension or congestive heart failure or of establishing renin as a causative factor in these problems which employ the novel peptides.
    Type: Grant
    Filed: March 8, 1989
    Date of Patent: August 6, 1991
    Assignee: Merck & Co., Inc.
    Inventors: Arthur A. Patchett, William J. Greenlee, William H. Parsons, Prasun K. Chakravarty
  • Method of treating bacterial infection with phosphorus containing DHP enzyme inhibitors
    Patent number: 4962097
    Abstract: Dipeptide mimics which contain phosphorus and their pharmaceutical use and preparation are disclosed. The compounds have dehydropeptidase (DHP) enzyme inhibitor activity.
    Type: Grant
    Filed: August 17, 1989
    Date of Patent: October 9, 1990
    Assignee: Merck & Co., Inc.
    Inventors: William H. Parsons, William R. Schoen, ARthur A. Patchett
  • Fungicidal compositions and method
    Patent number: 4921844
    Abstract: Novel fungicidal compositions comprising a 25-azasterol composition and a .beta.-ketothiolase inhibitor compound are disclosed.
    Type: Grant
    Filed: April 18, 1988
    Date of Patent: May 1, 1990
    Assignee: Merck & Co., Inc.
    Inventors: Janet C. Onishi, Arthur A. Patchett
  • Fungicidal compositions and method
    Patent number: 4920112
    Abstract: Novel fungicidal compositions comprising a 25-azasterol compound and a squalene epoxidase inhibitor compound are disclosed.
    Type: Grant
    Filed: April 18, 1988
    Date of Patent: April 24, 1990
    Assignee: Merck & Co., Inc.
    Inventors: Janet C. Onishi, Arthur A. Patchett
  • Fungicidal compositions and methods utilizing 25-azasterol and HMG-CoA synthase inhibitors
    Patent number: 4920113
    Abstract: Novel fungicidal compositions comprising a 25-azasterol compound and a HMG-CoA synthase inhibitor compound are disclosed.
    Type: Grant
    Filed: April 18, 1988
    Date of Patent: April 24, 1990
    Assignee: Merck & Co., Inc.
    Inventors: Janet C. Onishi, Arthur A. Patchett
  • Fungicidal compositions and methods utilizing 25-azasterol and HMG-CoA reductase inhibitors
    Patent number: 4920111
    Abstract: Novel fungicidal composition comprising a 25-azasterol compound and a HMG-CoA reductase inhibitor compound are disclosed.
    Type: Grant
    Filed: April 18, 1988
    Date of Patent: April 24, 1990
    Assignee: Merck & Co., Inc.
    Inventors: Janet C. Onishi, Arthur A. Patchett
  • Antifungal compositions and method of controlling mycotic infections
    Patent number: 4920109
    Abstract: Method of potentiating antifungal agents with 25-azasterol compound to produce superior antifungal compositions and use of the compositions to control mycotic infections is disclosed.
    Type: Grant
    Filed: April 18, 1988
    Date of Patent: April 24, 1990
    Assignee: Merck & Co., Inc.
    Inventors: Janet C. Onishi, Arthur A. Patchett
  • Benzofused lactams as antihypertensives
    Patent number: 4873235
    Abstract: Benzofused lactams of the formula: ##STR1## and their use as angiotensin converting enzyme inhibitors and antihypertensive agents are disclosed.
    Type: Grant
    Filed: March 16, 1983
    Date of Patent: October 10, 1989
    Assignee: Merck & Co., Inc.
    Inventors: William H. Parsons, Arthur A. Patchett, Eugene D. Thorsett
  • Carboxyalkyl urea compounds and derivatives thereof useful as angiotensin converting enzyme inhibitors and as antihypertensives
    Patent number: 4866087
    Abstract: Carboxyalkyl urea compounds and derivatives thereof are disclosed which are useful as angiotensin converting enzyme (ACE) inhibitors and as antihypertensives. These compounds and derivatives are represented by the general formula: ##STR1## An illustrative specie falling within this general formula is:N-(2-carboxy-4-phenylbutyl-N-isopropylaminocarbonyl-L-tryptophan.
    Type: Grant
    Filed: June 27, 1983
    Date of Patent: September 12, 1989
    Assignee: Merck & Co., Inc.
    Inventors: William J. Greenlee, David G. Hangauer, Jr., Arthur A. Patchett
  • Renin inhibitors containing phenylalanyl-histidine replacements
    Patent number: 4839357
    Abstract: Peptides of the formula: ##STR1## which comprise novel elements replacing the Phe(8)-His(9) sequence in renin-inhibitory peptides based on substrate analogy, which inhibit the substrate-cleaving action of renin and have improved bioavailability; compositions containing these renin-inhibitory peptides, optionally with other antihypertensive agents; and methods of treating hypertension or congestive heart failure or of establishing renin as a causative factor in these problems which employ the novel peptides.
    Type: Grant
    Filed: October 2, 1987
    Date of Patent: June 13, 1989
    Assignee: Merck & Co., Inc.
    Inventors: Arthur A. Patchett, William J. Greenlee, William H. Parsons, Prasun K. Chakravarty
  • Antihypercholesterolemic beta-lactones
    Patent number: 4751237
    Abstract: The compounds of the following general structural formula (I) ##STR1## wherein R is hydrogen or C.sub.1-3 alkyl and the tetrahydro analogs thereof, are 3-hydroxy-3-methylglutarylcoenzyme A (HMG-CoA) synthase inhibitors and useful as antihypercholesterolemic agents for the treatment of disease in which the inhibition of cholesterol biosynthesis would by useful, such as arteriosclerosis, hyperlipidemia and familial hypercholesterolemia.
    Type: Grant
    Filed: April 28, 1986
    Date of Patent: June 14, 1988
    Assignee: Merck & Co., Inc.
    Inventors: John C. Chabala, Arthur A. Patchett, Michael D. Greenspan
  • 3-Halovinylglycine antibacterial agents
    Patent number: 4727062
    Abstract: Described are 3-halovinylglycines and their amino acid dipeptide and oligopeptide conjugates, a new class of efficient antibacterial agents, pharmaceutical compositions containing them as active ingredients, and methods of synthesis. The compounds are thought to interfere in bacterial cell wall synthesis.
    Type: Grant
    Filed: March 17, 1986
    Date of Patent: February 23, 1988
    Assignee: Merck & Co., Inc.
    Inventors: David Taub, Robert H. Abeles, Arthur A. Patchett