Abstract: In a multi-layer woven fabric in which a first yarn system forms yarn layers between the opposite broad surfaces of the fabric and a second yarn system extends through the fabric thickness between the opposite broad surfaces and is interwoven with the yarn layers, at least one of the first and second yarn systems is comprised of two or more different yarn groups of different material composition disposed within different portions of the thickness of the fabric. This enables different materials such as carbon, ceramics, metals and organics to be disposed uniformly throughout the fabric thickness or to be concentrated within particular portions of the fabric thickness. In this manner multi-layer woven fabrics can be customized for particular applications in terms of their chemical, electrical, thermal, ablative, optical or other properties while retaining the advantageous structural characteristics of such fabrics. Both angle interlock and layer-to-layer weaving configurations may be used.