Patents by Inventor Arthur R. McFadden

Arthur R. McFadden has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 6,11-dihydrodibenz[b,e]oxepin-acetic acids and derivatives
    Patent number: 4816591
    Abstract: 6,11-Dihydrodibenz[b,e]oxepin-acetic acids and derivatives having the general formula ##STR1## are prepared by multi-steps sequences. X is C.dbd.O, CHCl, CHBr, CH.sub.2 or CHOR.sup.4 ; Y is alkyl or alkoxy of 1 to 4 carbon atoms, halogen or trifluoromethyl; n is 0, 1, 2 or 3; Z is COOR.sup.5, CH.sub.2 OR.sup.5, CONR.sub.2.sup.5 or CONHOR.sup.5 ; and R.sup.1 -R.sup.5 are hydrogen or alkyl of 1 to 4 carbon atoms.These compounds and the physiologically tolerable salts thereof are useful as antiinflammatory and analgesic agents.
    Type: Grant
    Filed: November 5, 1979
    Date of Patent: March 28, 1989
    Assignee: American Hoechst Corporation
    Inventors: Grover C. Helsley, Arthur R. McFadden, David Hoffman
  • 6,11-dihydrodibenz[b,e]oxepin-acetic acids and derivatives
    Patent number: 4585788
    Abstract: 6,11-Dihydrodibenz[b,e]oxepin-acetic acids and derivatives having the general formula ##STR1## are prepared by multi-step sequences. X is C.dbd.O, CHCl, CHBr, CH.sub.2 or CHOR.sup.4 ; Y is alkyl or alkoxy of 1 to 4 carbon atoms, halogen or trifluoromethyl; n is 0, 1, 2 or 3; Z is COOR.sup.5, CH.sub.2 OR.sup.5, CONR.sub.2.sup.5 or CONHOR.sup.5 ; and R.sup.1 -R.sup.5 are hydrogen or alkyl of 1 to 4 carbon atoms.These compounds and the physiologically tolerable salts thereof are useful as antiinflammatory and analgesic agents.
    Type: Grant
    Filed: April 10, 1974
    Date of Patent: April 29, 1986
    Assignee: American Hoechst Corporation
    Inventors: Grover C. Helsley, Arthur R. McFadden, David Hoffman
  • Process for preparing heteroarylbenzoxepin-acetic acids, precursors and derivatives thereof
    Patent number: 4345087
    Abstract: Heteroarylbenzoxepin-acetic acids, esters thereof, novel precursors thereof, pharmaceutically acceptable salts thereof and processes for their preparation are disclosed. These compounds are useful as antiinflammatory and analgesic agents.
    Type: Grant
    Filed: March 7, 1980
    Date of Patent: August 17, 1982
    Assignee: American Hoechst Corporation
    Inventors: Arthur R. McFadden, Daniel E. Aultz
  • Dihydro-dibenzoxepines-thiepines and -morphanthridones, compositions and use
    Patent number: 4335122
    Abstract: The invention relates to diuretic dihydro-dibenzoxepines-thiepines and -morphanthridones of the formula ##STR1## wherein R is ##STR2## where R.sup.4 is a hydrogen or an alkyl; R.sup.1 is hydrogen or alkyl; R.sup.2 and R.sup.3 are the same or different and are hydrogen, alkyl or R.sup.2 and R.sup.3 are fused to form a pyrrolidino, morpholino, piperidino or azepino ring substituent; Y is hydrogen, halogen and alkoxy, X is ##STR3## where R.sup.4 is as defined above; m is an integer of 0 or 1; and n is an integer of 2 or 3; and the pharmaceutically acceptable acid addition salts thereof.
    Type: Grant
    Filed: March 18, 1981
    Date of Patent: June 15, 1982
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventors: Arthur R. McFadden, Daniel E. Aultz
  • Preparation of 6,11-dihydro-11-oxodibenz[b,e]-oxepin-2-acetic acid and precursors therefor
    Patent number: 4175209
    Abstract: A process, and intermediates for the preparation of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid are described. The acid possesses antiinflammatory and analgesic activity.
    Type: Grant
    Filed: September 5, 1978
    Date of Patent: November 20, 1979
    Assignee: American Hoechst Corporation
    Inventors: Arthur R. McFadden, Richard C. Allen, Thomas B. K. Lee
  • 4-Benzyloxy-3-(chlorocarbonyl)-phenylacetyl chloride
    Patent number: 4160781
    Abstract: A process, and intermediates for the preparation of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid are described. The acid possesses antiinflammatory and analgesic activity.
    Type: Grant
    Filed: September 5, 1978
    Date of Patent: July 10, 1979
    Assignee: American Hoechst Corporation
    Inventors: Arthur R. McFadden, Richard C. Allen, Thomas B. K. Lee
  • 4-Benzyloxy-3-(benzyloxy carbonyl)phenylthioacetmorpholide
    Patent number: 4153790
    Abstract: A process, and intermediates for the preparation of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid are described. The acid possesses antiinflammatory and analgesic activity.
    Type: Grant
    Filed: September 5, 1978
    Date of Patent: May 8, 1979
    Assignee: American Hoechst Corporation
    Inventors: Arthur R. McFadden, Richard C. Allen, Thomas B. K. Lee
  • 3-Carboxy-4 hydroxyphenylthioacetmorpholide
    Patent number: 4153791
    Abstract: A process, and intermediates for the preparation of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid are described. The acid possesses antiinflammatory and analgesic activity.
    Type: Grant
    Filed: September 5, 1978
    Date of Patent: May 8, 1979
    Assignee: American Hoechst Corporation
    Inventors: Arthur R. McFadden, Richard C. Allen, Thomas B. K. Lee
  • Oxopyridobenzoxepin-acetic acids and derivatives thereof useful as antiinflammatory and analgesic agents
    Patent number: 4124713
    Abstract: Oxopyridobenzoxepin acetic acids, esters thereof, novel precursors thereof, pharmaceutically acceptable salts thereof and processes for their preparation are disclosed. These compounds are useful as antiinflammatory and analgesic agents.
    Type: Grant
    Filed: April 19, 1977
    Date of Patent: November 7, 1978
    Assignee: American Hoechst Corporation
    Inventors: Arthur R. McFadden, Daniel E. Aultz
  • Preparation of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid and precursors therefor
    Patent number: 4118401
    Abstract: A process, and intermediates for the preparation of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid are described. The acid possesses antiinflammatory and analgesic activity.
    Type: Grant
    Filed: October 19, 1977
    Date of Patent: October 3, 1978
    Assignee: American Hoechst Corporation
    Inventors: Arthur R. McFadden, Richard C. Allen, Thomas B. K. Lee
  • Benzyl and related esters of 6,11-dihydrodibenz[b,e]oxepin-acetic acids
    Patent number: 4107322
    Abstract: Benzyl and related esters of 6,11-dihydrodibenz[b,e]oxepin-acetic and method for preparing same are described. These compounds are valuable as systemic and topical anti-inflammatory agents.
    Type: Grant
    Filed: June 3, 1976
    Date of Patent: August 15, 1978
    Assignee: American Hoechst Corporation
    Inventors: Arthur R. McFadden, Grover C. Helsley