Patents by Inventor Arthur R. Mlodozeniec

Arthur R. Mlodozeniec has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4478822
    Abstract: This invention relates to a unique drug delivery system for delivering drugs to a body cavity. The drug delivery system comprises a medicament and a polymer such that the drug delivery system is a liquid at room temperature but forms a semi-solid or gel at the body temperature in the body cavity.
    Type: Grant
    Filed: May 16, 1983
    Date of Patent: October 23, 1984
    Assignee: Merck & Co., Inc.
    Inventors: John L. Haslam, Takeru Higuchi, Arthur R. Mlodozeniec
  • Patent number: 4474751
    Abstract: This invention describes the application of selected polymers as novel drug delivery systems which use the body temperature and pH to induce a liquid to gel transition of the polymer which contains a drug or therapeutic agent therein. The goal of such a delivery system is to achieve a greater degree of bioavailability or sustained concentration of a drug.
    Type: Grant
    Filed: May 16, 1983
    Date of Patent: October 2, 1984
    Assignee: Merck & Co., Inc.
    Inventors: John L. Haslam, Takeru Higuchi, Arthur R. Mlodozeniec
  • Patent number: 4474752
    Abstract: Present invention provides a unique drug delivery device for delivering drug by injection into a body. The drug delivery system comprises the drug and polymer which is a liquid at room temperature and a semi-solid or gel at the body temperature.
    Type: Grant
    Filed: May 16, 1983
    Date of Patent: October 2, 1984
    Assignee: Merck & Co., Inc.
    Inventors: John L. Haslam, Takeru Higuchi, Arthur R. Mlodozeniec
  • Patent number: 4474753
    Abstract: This invention relates to a unique drug delivery system for application to the skin which drug delivery system is a liquid at room temperature, but when administered topically to the skin becomes a semi-solid or gel when warmed by the body.
    Type: Grant
    Filed: May 16, 1983
    Date of Patent: October 2, 1984
    Assignee: Merck & Co., Inc.
    Inventors: John L. Haslam, Takeru Higuchi, Arthur R. Mlodozeniec
  • Patent number: 4349531
    Abstract: Pharmaceutical dosage forms comprising an edible web having deposited thereon or at least partially thereon a particulate medicament, the webs being thereafter fabricated and finished to pharmaceutically elegant solid dosage forms having no medicament exposed on an exterior surface. The dosage forms have a consistency of release of medicament which can be controlled to exacting specifications. The disclosed solid dosage forms are prepared by high speed automated equipment and the process by which they are made is characterized by non-destructive quality control analysis and performance evaluation both conducted on-line and integrated into the manufacturing operation. Included in the scope of the disclosed invention are certain apparatus and methods of manufacture.
    Type: Grant
    Filed: October 4, 1979
    Date of Patent: September 14, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Arthur R. Mlodozeniec, Arthur H. Goldberg
  • Patent number: 4332789
    Abstract: Pharmaceutical dosage forms comprising an edible web having deposited theron or at least partially thereon a particulate medicament, the webs being thereafter fabricated and finished to pharmaceutically elegant solid dosage forms having no medicament exposed on an exterior surface. The dosage forms have a consistency of release of medicament which can be controlled to exacting specifications. The disclosed solid dosage forms are prepared by high speed automated equipment and the process by which they are made is characterized by non-destructive quality control analysis and performance evaluation both conducted on-line and integrated into the manufacturing operation. Included in the scope of the disclosed invention are certain apparatus and methods of manufacture.
    Type: Grant
    Filed: August 24, 1977
    Date of Patent: June 1, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Arthur R. Mlodozeniec
  • Patent number: 4307555
    Abstract: Pharmaceutical dosage forms comprising an edible web having deposited thereon or at least partially thereon a particulate medicament, the webs being thereafter fabricated and finished to pharmaceutically elegant solid dosage forms having no medicament exposed on an exterior surface. The dosage forms have a consistency of release of medicament which can be controlled to exacting specifications. The disclosed solid dosage forms are prepared by high speed automated equipment and the process by which they are made is characterized by non-destructive quality control analysis and performance evaluation both conducted on-line and integrated into the manufacturing operation. Included in the scope of the disclosed invention are certain apparatus and methods of manufacture.
    Type: Grant
    Filed: October 4, 1979
    Date of Patent: December 29, 1981
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Arthur R. Mlodozeniec, Arthur H. Goldberg
  • Patent number: 4197289
    Abstract: Pharmaceutical dosage forms comprising an edible web having deposited thereon or at least partially thereon a particulate medicament, the webs being thereafter fabricated and finished to pharmaceutically elegant solid dosage forms having no medicament exposed on an exterior surface. The doseage forms have a consistency of release of medicament which can be controlled to exacting specifications. The disclosed solid dosage forms are prepared by high speed automated equipment and the process by which they are made is characterized by non-destructive quality control analysis and performance evaluation both conducted on-line and integrated into the manufacturing operation. Included in the scope of the disclosed invention are certain apparatus and methods of manufacture.
    Type: Grant
    Filed: August 15, 1978
    Date of Patent: April 8, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventors: August Sturzenegger, Arthur R. Mlodozeniec, Edward S. Lipinsky
  • Patent number: 4128445
    Abstract: Pharmaceutical dosage forms comprising an edible web having deposited thereon or at least partially thereon a particulate medicament, the webs being thereafter fabricated and finished to pharmaceutically elegant solid dosage forms having no medicament exposed on an exterior surface. The dosage forms have a consistency of release of medicament which can be controlled to exacting specifications. The disclosed solid dosage forms are prepared by high speed automated equipment and the process by which they are made is characterized by non-destructive quality control analysis and performance evaluation both conducted on-line and integrated into the manufacturing operation. Included in the scope of the disclosed invention are certain apparatus and methods of manufacture.
    Type: Grant
    Filed: August 18, 1977
    Date of Patent: December 5, 1978
    Assignee: Hoffmann-La Roche Inc.
    Inventors: August Sturzenegger, Arthur R. Mlodozeniec, Edward S. Lipinsky
  • Patent number: 4128444
    Abstract: Pharmaceutical dosage forms comprising an edible web having deposited thereon or at least partially thereon a particulate medicament, the webs being thereafter fabricated and finished to pharmaceutically elegant solid dosage forms having no medicament exposed on an exterior surface. The dosage forms have a consistency of release of medicament which can be controlled to exacting specifications. The disclosed solid dosage forms are prepared by high speed automated equipment and the process by which they are made is characterized by non-destructive quality control analysis and performance evaluation both conducted on-line and integrated into the manufacturing operation. Included in the scope of the disclosed invention are certain apparatus and methods of manufacture.
    Type: Grant
    Filed: August 10, 1977
    Date of Patent: December 5, 1978
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Arthur R. Mlodozeniec