Patents by Inventor Arthur Reis

Arthur Reis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods, kits and reaction mixtures for analyzing single-stranded nucleic acid sequences
    Patent number: 9353407
    Abstract: Provided herein are fluorescence detection methods for nucleic acid sequences and to kits for performing such methods.
    Type: Grant
    Filed: October 21, 2010
    Date of Patent: May 31, 2016
    Assignee: Brandeis University
    Inventors: Lawrence Wangh, John Rice, J. Aquiles Sanchez, Arthur Reis
  • PRIMERS, PROBES AND METHODS FOR NUCLEIC ACID AMPLIFICATION
    Publication number: 20130095479
    Abstract: Homogenous detection during or following PCR amplification, preferably LATE-PCR, utilizing fluorescent DNA dye and indirectly excitable labeled primers and probes, improves reproducibility and quantification. Low-temperature homogeneous detection during or following non-symmetric PCR amplification, preferably LATE-PCR, utilizing fluorescent DNA dye and indirectly excitable labeled mismatch-tolerant probes permits analysis of complex targets. Sequencing sample preparation methods following LATE-PCR amplifications reduce complexity and permit “single-tube” processing.
    Type: Application
    Filed: August 1, 2012
    Publication date: April 18, 2013
    Applicant: BRANDEIS UNIVERSITY
    Inventors: Lawrence J. Wangh, John Rice, J. Aquilles Sanchez, Kenneth Pierce, Jesse Salk, Arthur Reis, Cristina Hartshorn
  • METHODS, KITS AND REACTION MIXTURES FOR ANALYZING SINGLE-STRANDED NUCLEIC ACID SEQUENCES
    Publication number: 20120282611
    Abstract: Provided herein are fluorescence detection methods for nucleic acid sequences and to kits for performing such methods.
    Type: Application
    Filed: October 21, 2010
    Publication date: November 8, 2012
    Applicant: BRANDEIS UNIVERSITY
    Inventors: Lawrence Wangh, John Rice, J. Aquiles Sanchez, Arthur Reis
  • Primers, probes and methods for nucleic acid amplification
    Publication number: 20120040352
    Abstract: Homogenous detection during or following PCR amplification, preferably LATE-PCR, utilizing fluorescent DNA dye and indirectly excitable labeled primers and probes, improves reproducibility and quantification. Low-temperature homogeneous detection during or following non-symmetric PCR amplification, preferably LATE-PCR, utilizing fluorescent DNA dye and indirectly excitable labeled mismatch-tolerant probes permits analysis of complex targets. Sequencing sample preparation methods following LATE-PCR amplifications reduce complexity and permit “single-tube” processing.
    Type: Application
    Filed: November 10, 2008
    Publication date: February 16, 2012
    Inventors: Lawrence J. Wangh, John Rice, J. Aquiles Sanchez, Kenneth Pierce, Jesse Salk, Arthur Reis, Cristina Hartshorn
  • Primers, probes and methods for nucleic acid amplification
    Patent number: 7632642
    Abstract: Homogenous detection during or following PCR amplification, preferably LATE-PCR, utilizing fluorescent DNA dye and indirectly excitable labeled primers and probes, improves reproducibility and quantification. Low-temperature homogeneous detection during or following non-symmetric PCR amplification, preferably LATE-PCR, utilizing fluorescent DNA dye and indirectly excitable labeled mismatch-tolerant probes permits analysis of complex targets. Sequencing sample preparation methods following LATE-PCR amplifications reduce complexity and permit “single-tube” processing.
    Type: Grant
    Filed: October 17, 2005
    Date of Patent: December 15, 2009
    Assignee: Brandeis University
    Inventors: Lawrence J. Wangh, John Rice, J. Aquiles Sanchez, Kenneth Pierce, Jesse Salk, Arthur Reis, Cristina Hartshorn
  • Reagents and methods for improving reproducibility and reducing mispriming in PCR amplification
    Publication number: 20090226973
    Abstract: An additive for preventing mispriming in polymerase chain reaction (PCR) amplifications and assays comprising a hairpin oligonucleotide having a stem duplex greater than six nucleotides in length and a stabilized stem terminus. The additive improves PCR amplifications, including LATE-PCR amplifications when added to initial amplification reaction mixtures. It can be included in oligonucleotide sets and in kits for PCR amplification and assays.
    Type: Application
    Filed: March 20, 2009
    Publication date: September 10, 2009
    Inventors: Lawrence J. Wangh, John Rice, J. Aquiles Sanchez, Kenneth Pierce, Jesse Salk, Arthur Reis, Cristina Hartshorn
  • Reagents and methods for improving reproducibility and reducing mispriming in PCR amplification
    Patent number: 7517977
    Abstract: An additive for preventing mispriming in polymerase chain reaction (PCR) amplifications and assays comprising a hairpin oligonucleotide having a stem duplex greater than six nucleotides in length and a stabilized stem terminus. The additive improves PCR amplifications, including LATE-PCR amplifications when added to initial amplification reaction mixtures. It can be included in oligonucleotide sets and in kits for PCR amplification and assays.
    Type: Grant
    Filed: October 17, 2005
    Date of Patent: April 14, 2009
    Assignee: Brandeis University
    Inventors: Lawrence J. Wangh, John Rice, J. Aquiles Sanchez, Kenneth Pierce, Jesse Salk, Arthur Reis, Cristina Hartshorn
  • Primers, probes and methods for nucleic acid amplification
    Publication number: 20060177841
    Abstract: Homogenous detection during or following PCR amplification, preferably LATE-PCR, utilizing fluorescent DNA dye and indirectly excitable labeled primers and probes, improves reproducibility and quantification. Low-temperature homogeneous detection during or following non-symmetric PCR amplification, preferably LATE-PCR, utilizing fluorescent DNA dye and indirectly excitable labeled mismatch-tolerant probes permits analysis of complex targets. Sequencing sample preparation methods following LATE-PCR amplifications reduce complexity and permit “single-tube” processing.
    Type: Application
    Filed: October 17, 2005
    Publication date: August 10, 2006
    Inventors: Lawrence Wangh, John Rice, J. Sanchez, Kenneth Pierce, Jesse Salk, Arthur Reis, Cristina Hartshorn
  • Reagents and methods for improving reproducibility and reducing mispriming in PCR amplification
    Publication number: 20060177842
    Abstract: An additive for preventing mispriming in polymerase chain reaction (PCR) amplifications and assays comprising a hairpin oligonucleotide having a stem duplex greater than six nucleotides in length and a stabilized stem terminus. The additive improves PCR amplifications, including LATE-PCR amplifications when added to initial amplification reaction mixtures. It can be included in oligonucleotide sets and in kits for PCR amplification and assays.
    Type: Application
    Filed: October 17, 2005
    Publication date: August 10, 2006
    Inventors: Lawrence Wangh, John Rice, J. Sanchez, Kenneth Pierce, Jesse Salk, Arthur Reis, Cristina Hartshorn