Abstract: A discrete drop dispensing device comprises a substrate comprising an upper surface and a lower surface and orifices extending from the upper surface to the lower surface, adapted to receive a fluid at a flow rate. The discrete drop dispensing device also comprises an oscillator disposed adjacent to the substrate and configured to vibrate the substrate to expel drops having a substantially equal volume of the fluid. The flow rate is substantially identical to a drop dispensing rate. A method and a device for performing liquid chromatography are also described. The method comprises automatically adjusting the drop dispensing rate to a change in the flow rate or a change in a composition of a mobile phase of the fluid.

Abstract: A discrete drop dispensing device comprises a substrate comprising an upper surface and a lower surface and orifices extending from the upper surface to the lower surface, adapted to receive a fluid at a flow rate. The discrete drop dispensing device also comprises an oscillator disposed adjacent to the substrate and configured to vibrate the substrate to expel drops having a substantially equal volume of the fluid. The flow rate is substantially identical to a drop dispensing rate. A method and a device for performing liquid chromatography are also described. The method comprises automatically adjusting the drop dispensing rate to a change in the flow rate or a change in a composition of a mobile phase of the fluid.

Abstract: A method, apparatus and kit forms a plurality of closed reaction chambers to simultaneously conduct multiple chemical reactions. The apparatus includes a plate of wells and an array of sets of bound chemical reactants. A well has a deformable closed end and an open end opposite the closed end. When assembled together, the array covers open ends of the wells in the plate to form a reaction assembly having a plurality of closed cells that is one or more of gas, liquid and/or fluid tight. The deformable closed end of the well is flexible such that a test sample is displaced toward a set of chemical reactants in a closed cell for mixing. The array may include spatially arranged prongs distally extending from a support with the sets of chemical reactants bound to distal ends of prongs.