Abstract: A method and device for increasing microcirculation in the lower limb are described. The device includes a means for immobilizing the limb, for example a plaster cast, and an electrical stimulation device, which applies electrical stimulation to opposed leg muscles such that antagonistic and agonistic muscle groups contract near simultaneously, resulting in near isometric contraction. The combination of this contraction and the leg restraint have been found to markedly increase blood circulation and in particular microcirculation in the limb.

Abstract: The present invention provides a system comprising: (i) a layer containing a nitrite; and (ii) a hydrogel that contains hydrogen ions; wherein the layer containing a nitrite and/or the hydrogel comprises a pharmaceutically active agent. The invention also provides the use of a system of the invention in medicine, and in the treatment of pain.

Abstract: The present invention provides a system comprising: (i) a layer containing a nitrite; and (ii) a hydrogel that contains hydrogen ions. The invention also provides the use of a system of the invention for the treatment of a condition associated with tissue ischaemia or a wound and the use of a system of the invention in combination with an anaesthetic for the treatment or prevention of pain.

Abstract: The present invention provides a system comprising: (i) a layer containing a nitrite; and (ii) a hydrogel that contains hydrogen ions; wherein the layer containing a nitrite and/or the hydrogel comprises a pharmaceutically active agent. The invention also provides the use of a system of the invention in medicine, and in the treatment of pain.

Abstract: The present invention provides a system comprising: (i) a layer containing a nitrite; and (ii) a hydrogel that contains hydrogen ions. The invention also provides the use of a system of the invention for the treatment of a condition associated with tissue ischaemia or a wound and the use of a system of the invention in combination with an anaesthetic for the treatment or prevention of pain.

Abstract: The use of liquid formulations in the preparation of a medicament for the prevention and treatment of oral, gastric and digestive infections and in particular for the prevention of ventilator associated pneumonia as well as liquid enteral and parenteral tube feeding compositions. The feeding compositions are suitable for use in the prevention of ventilator associated pneumonia.

Abstract: The use of liquid formulations in the preparation of a medicament for the prevention and treatment of oral, gastric and digestive infections and in particular for the prevention of ventilator associated pneumonia as well as liquid enteral and parenteral tube feeding compositions. The feeding compositions are suitable for use in the prevention of ventilator associated pneumonia.

Abstract: A pharmaceutically delivery system is described comprising a pharmaceutically active agent and acidified nitrite as an agent to produce local production of nitric oxide at the skin surface. The dosage form may be in any pharmaceutically acceptable carrier means and comprises an acidifying agent adapted to reduce the pH at the environment. In one embodiment, a barrier consisting of a membrane allows diffusions of the anaesthetic and nitrite ions while preventing direct contact of the skin and acidifying agent.

Abstract: The present invention provides a method and device for reduction of or treatment of deep vein thrombosis (DVT), the method comprising causing isometric stimulation of the leg muscles to promote blood flow. Other embodiments provide treatment for other circulatory disorders of the lower limbs and/or the systemic circulation.

Abstract: The present invention describes the use of transcutaneous electrical stimulation of a nerve emanating from the sacral plexus for the treatment or alleviation of incontinence. In preferred embodiments, the lateral popliteal nerve is stimulated in the region of the popliteal fossa. The stimulation is noninvasive.

Abstract: The present invention provides a method and device for reduction of or treatment of deep vein thrombosis (DVT), the method comprising causing isometric stimulation of the leg muscles to promote blood flow. Other embodiments provide treatment for other circulatory disorders of the lower limbs and/or the systemic circulation.

Abstract: The use of liquid formulations in the preparation of a medicament for the prevention and treatment of oral, gastric and digestive infections and in particular for the prevention of ventilator associated pneumonia as well as liquid enteral and parenteral tube feeding compositions. The feeding compositions are suitable for use in the prevention of ventilator associated pneumonia.