Patents by Inventor Arthur Tzianabos

Arthur Tzianabos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • THERAPEUTIC COMPOSITIONS
    Publication number: 20110059172
    Abstract: Therapeutic compositions containing therapeutic agents and poly(beta-amino esters) or polymers thereof are described. These tertiary amine-containing polymers are preferably biodegradable and biocompatible. Nanoparticles and microparticles containing polymer/therapeutic agent complexes are also described.
    Type: Application
    Filed: January 28, 2009
    Publication date: March 10, 2011
    Inventors: Arthur Tzianabos, Michael W. Heartlein
  • THERAPEUTIC COMPOSITIONS
    Publication number: 20110052673
    Abstract: Therapeutic compositions containing therapeutic agents and nitrogen-containing lipids are described. These tertiary amine-containing polymers are preferably biodegradable and biocompatible. Nanoparticles, microparticles, and complexes containing lipid/therapeutic agent complexes are also described.
    Type: Application
    Filed: January 28, 2009
    Publication date: March 3, 2011
    Inventors: Arthur Tzianabos, Michael W. Heartlein
  • Method for overexpression of zwitterionic polysaccharides
    Publication number: 20080057565
    Abstract: The present invention is directed to methods for producing and selecting novel mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; compositions directed to the novel mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; improved methods for purification of individual capsular polysaccharides; and compositions directed to novel res02 and inv19 genes and their gene products. Significantly, the present invention provides methods and compositions for overexpressing and purifying immunomodulatory capsular polysaccharide A (PSA) in high yield.
    Type: Application
    Filed: August 20, 2007
    Publication date: March 6, 2008
    Applicant: The Brigham and Women's Hospital, Inc.
    Inventors: Laurie Comstock, Michael Coyne, Dennis Kasper, Arthur Tzianabos, Katja Weinacht
  • Method for overexpression of zwitterionic polysaccharides
    Publication number: 20070154991
    Abstract: The present invention is directed to methods for producing and selecting novel mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; compositions directed to the novel mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; improved methods for purification of individual capsular polysaccharides; and compositions directed to novel res02 and inv19 genes and their gene products. Significantly, the present invention provides methods and compositions for overexpressing and purifying immunomodulatory capsular polysaccharide A (PSA) in high yield.
    Type: Application
    Filed: January 17, 2007
    Publication date: July 5, 2007
    Applicant: The Brigham and Women's Hospital, Inc.
    Inventors: Laurie Comstock, Michael Coyne, Dennis Kasper, Arthur Tzianabos, Katja Weinacht
  • Method for overexpression of zwitterionic polysaccharides
    Publication number: 20070020730
    Abstract: The present invention is directed to methods for producing and selecting novel mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; compositions directed to the novel mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; improved methods for purification of individual capsular polysaccharides; and compositions directed to novel res02 and inv19 genes and their gene products. Significantly, the present invention provides methods and compositions for overexpressing and purifying immunomodulatory capsular polysaccharide A (PSA) in high yield.
    Type: Application
    Filed: September 26, 2006
    Publication date: January 25, 2007
    Applicant: The Brigham and Women's Hospital, Inc.
    Inventors: Laurie Comstock, Michael Coyne, Dennis Kasper, Arthur Tzianabos, Katja Weinacht
  • Immunomodulating polymers
    Publication number: 20060153832
    Abstract: Methods and products for inducing IL-2 secretion, inducing IL-10 secretion, activating T cells, suppressing IgG antibody response to specific antigen, promoting allograft survival, reducing postoperative surgical adhesion formation, and protecting against abscess formation associated with surgery, trauma or diseases that predispose the host to abscess formation are provided. The methods of the invention are accomplished using an immunomodulator which is a polymer having at least two repeating charge motifs separated by at least a certain minimum distance.
    Type: Application
    Filed: March 21, 2006
    Publication date: July 13, 2006
    Applicant: The Brigham and Women's Hospital, Inc.
    Inventors: Arthur Tzianabos, Dennis Kasper, Andrew Onderdonk, Ying Wang
  • Immunomodulatory compositions and methods of use thereof
    Publication number: 20060029662
    Abstract: The invention relates to immunomodulatory compositions and related methods. The immunomodulatory compositions of a formula disclosed herein are useful for the prevention of sepsis and the treatment and prevention of diseases associated with inflammation and/or NOS.
    Type: Application
    Filed: July 7, 2005
    Publication date: February 9, 2006
    Applicants: Genzyme Corporation, The Brigham and Women's Hospital, Inc.
    Inventors: Pericles Calias, Robert Miller, Andrew Onderdonk, Arthur Tzianabos
  • Immunomodulating polymers
    Publication number: 20040209818
    Abstract: Methods and products for inducing IL-2 secretion, inducing IL-10 secretion, activating T cells, suppressing IgG antibody response to specific antigen, promoting allograft survival, reducing postoperative surgical adhesion formation, and protecting against abscess formation associated with surgery, trauma or diseases that predispose the host to abscess formation are provided. The methods of the invention are accomplished using an immunomodulator which is a polymer having at least two repeating charge motifs separated by at least a certain minimum distance.
    Type: Application
    Filed: May 19, 2004
    Publication date: October 21, 2004
    Applicant: The Brigham and Women's Hospital, Inc.
    Inventors: Arthur Tzianabos, Dennis L. Kasper, Andrew B. Onderdonk, Ying Wang