Abstract: This invention relates generally to the field of medicine, and particularly to a TLR-9-specific inhibitor peptide effective in vitro and in vivo for modification of inflammatory signaling and host defense pathways. This peptide can be used for TLR-targeting pharmaceutics for treating inflammatory responses caused by various pathogenic and infectious diseases. The invention comprises peptides, peptide fusions, pharmaceutical compositions, and methods for using these compounds and compositions. Peptides of the invention include, but are not limited to SEQ ID NOs:4, 6, 8, 10, 12, 21, or 24, optionally fused to a cell-permeating moiety.

Abstract: This invention relates to the field of biotechnology. It describes organism immunostimulation, initiation of breakdown processes of cancerous cells and prevention of the formation of metastases, using water soluble ?-glucan compositions of various molecular masses. In this invention is also described unique biocatalyst produced by Streptomyces rutgersensis 88 and used to obtain ?-glucan mixtures, is also described.