Abstract: The invention is a cosmetic and pharmaceutical liposomal composition which comprises a mixture of carboxylated oligopeptides derived from natural polypeptides; insulin; hyaluronidase and collagenase by their enzymatic hydrolysis; followed by a carboxylation of the free amino groups of lysine, histidine, and additional hydrolysis of terminal amino groups in the oligopeptides. Natural polypeptides may be hydrolyzed with a proteolytic enzyme to form a mixture of oligopeptides and succinylated them. Next, the resulting mixture was injected into the liposomes by classical methods to improve the intestinal absorption and bioavailability in the body, prolonging the action of the system. Such a system behaves as quasi-live and is capable of forming supramolecular complexes with the original proteins, such as insulin and acylated insulin oligopeptides, or insulin receptors on a cell and acylated insulin's oligopeptides.

Abstract: A pharmaceutical composition comprising a mixture of carboxylated oligopeptides, derived by hydrolysis of eukaryotic or prokaryotic cells and their subsequent partial carboxylation through acylation or alkylation of the amino acid and basic amino acid residues in the amino terminal structure of the oligopeptides. The resulting pharmaceutical composition can be used in production of medical drugs effective in the treatment of cancer, pancreatitis, viral infection, for the development of vaccines.

Abstract: The invention describes a pharmaceutical composition, comprising a mixture of carboxylated oligonucleotides, obtained by hydrolysis of natural polynucleotides, that results in oligonucleotide mixture, and carboxylation of purine nucleotide bases in the oligonucleotide mixture. The oligonucleotide mixture (DNA, RNA, or a combination of the two) of plant, animal, or fungal origin is conducted through chemical or biochemical enzymatic procedures, and then, a chemical modification of the oligonucleotides is provided, with carboxylation of their purine nucleotide bases through alkylation with monochloroacetic acid, or acylation with succinic anhydride. The pharmaceutical composition may be used in humans and animals for cancer treatment, immunodeficiency, viral infection diseases, etc.

Abstract: A cosmetic and pharmaceutical formulation for rejuvenation and restoration of the skin, and methods of making this formulation. The cosmetic and pharmaceutical formulations comprise liposomes containing partially acylated proteins with a modification level of 0.1 to 10% of their mass, wherein the proteins are present in the form of a supramolecular assembly.

Abstract: A method of design and synthesis of a new drug. This invention may be used in human and veterinary medicine for the design of new drugs that are effective in the treatment of oncological and viral human and animal illnesses and for the design of new medicines. In the method a biopolymer target for the drug action is selected; then the quantity of nitrogen-containing positively charged groups available for modification is calculated. Biopolymer target may be cut into oligomer fragments. Some of calculated nitrogen-containing positively charged groups are substituted with negatively charged groups by combinatorial modification. The obtained supramolecular assemblies are used as drug for the biopolymer target.

Abstract: The invention presents a method of identifying natural biopolymer—a protein, DNA, RNA in biological fluids and environmental objects, which is based only on the structure of the biopolymer and does not require pathogen genome sequencing, or animals vaccination by biopolymer-antigen. For this purpose the biopolymer itself is taken—a protein, DNA, or RNA, that is fragmented with enzyme to oligomer fragments—a mixture of oligopeptides, oligonucleotides DNA mixture, mixture of RNA oligonucleotides, without dividing the mixture into individual components, then carboxylation of structure in oligomer components is performed by acylation or alkylation.

Abstract: This invention is related to pharmacology and cosmetology and may be used in the capacity of a medicinal and cosmetic substance for skin anti-aging, scar reduction, treatment of post-operative peritoneal commissures, increasing the speed of post-operative tissue regeneration, and for the liquidation of cellulite.

Abstract: This invention may be used in human and veterinary medicine in combination with traditional methods of treatment of oncological illnesses for the purpose of increasing their effectiveness. It is a method of treating patients with oncological diseases that is distinct in that an antiviral drug is used as an additional component of standard treatment before the beginning of and in parallel with standard treatment, in which Acyclovir, Valacyclovir, alpha interferon, a specific antiviral immunoglobulin or a combination of these substances are used as an antiviral drug, which may be used for inclusion in the standard surgical, radiological, or chemotherapeutic treatment plan for cancer patients. The proposed method allows us to significantly improve the results of the treatment of cancer patients, decrease the number of relapses, improve patients' quality of life, and significantly extend their lives.

Abstract: Modified oligopeptides for the treatment of pancreatitis, stomach ulcers, and other hyperenzymemias based on an enzyme peptide inhibitor where in the capacity of the main active ingredient, a mixture (assembly) of chemically modified oligopeptides are used that are products of autological hydrolysis of the same proteolytic enzymes of trypsin, chymotrypsin, and papain, with changes of their molecular charges to the opposite through acylation with succinic anhydride and alkylation by monochloracetic acid.

Abstract: The main active ingredients of the formula are papaverin, bendazol, and insulin. The drug may be produced in soft, liquid medicinal form or as an aerosol.

Abstract: Vaccines with increased immunogenicity, distinct in that in the capacity of a specific immunogenic component, whole vaccine antigens or vaccine antigens that have been cut into oligomer fragments are used; the mixture (assembly) of oligomer fragments or whole antigen obtained is modified by changing its molecular charge to the opposite.

Abstract: This invention may be used in human and veterinary medicine in combination with traditional methods of treatment of cardiovascular illnesses for the purpose of increasing their effectiveness. A method of treating patients with cardiovascular illnesses, distinct in that an anti-viral drug is used as an additional component of standard treatment before the beginning of and in parallel with standard treatment, in which Acyclovir, Valacyclovir, alpha interferon, a specific antiviral immunoglobulin or a combination of these substances are used as an anti-viral drug, which may be used for inclusion in the standard scheme of treatment of patients with cardiovascular diseases. The proposed method allows us to significantly improve the results of the treatment of patients with cardiovascular system pathology, decrease the number of relapses, improve patients' quality of life, and significantly extend their lives.

Abstract: A diagnostic method, in which patient tissue samples are taken, microassay are prepared, specific anti-viral immunoglobulins are processed, the number of cells infected by two or more viruses before the beginning of treatment are determined, and the dynamic of the change in the number of infected cells and their interrelationships are established: if the number of blood cells infected by any two or more viruses exceeds 50±10% in patients without signs of oncological pathology, a diagnostic conclusion is drawn of a high danger of oncological illness in connection with immune system ineffectiveness; if the number of cells infected by any two or more viruses exceeds 50±10% in patients with diagnosed oncological illnesses, a diagnostic conclusion of the cancer tumor's low sensitivity to chemotherapy and the perspective of quick tumor metastasis is drawn.

Abstract: This invention may be used in human and veterinary medicine for the creation of a drug that is effective in the treatment of oncological illnesses in animals and humans. Summary of the Invention Modified antisense oligonucleotides with anticancer properties and methods of obtaining them, distinct in that in the capacity of oligonucleotides, a mixture of the products of the hydrolysis of polynucleotides is used, and modification is done through changing the molecular charges of the nucleotide bases to their opposites; they thereby obtain antisense properties. The hydrolysis of polynucleotides leads to the application of natural or synthetic nucleases, acid or alkaline hydrolysis, and modification of the structure through the acylation of the amino groups of mononucleotides in the structure of oligonucleotides by dicarboxylic acids or through their alkylation by halogen-carboxylic acids.

Abstract: This invention may be used in human and veterinary medicine for the creation of a drug that is effective perorally in the treatment of many viral infections, such as influenza, herpes, and cytomegalovirus. Summary of the Invention Modified peptides with antiviral properties and methods for obtaining them, distinct in that in the capacity of the main active ingredient, a mixture (assembly) of oligopeptides is used that are the products of the hydrolysis of proteins with changes in their molecular charges to the opposite are used, and to obtain them, first a partial hydrolysis of protein-containing raw material is conducted, and then a process of chemical modification of the quantity of oligopeptides obtained with a change in the charge to the molecules is conducted; this is used as an antiviral vehicle for the composition of the oligopeptides obtained.

Abstract: This invention may be used in human and veterinary medicine for the creation of a drug that is effective perorally in the treatment of oncological illnesses. Modified oligopeptides with anticancer properties distinct in that in the capacity of peptides, a mixture (assembly) of oligopeptides are used that are products of the hydrolysis of proteins with molecules changed to the opposite charge. This quantity of modified oligopeptides is capable of slowing down the activity of the heterodimer of b-importin cells and the replication of viruses whose replication cycle depends on the function of the nucleus, as well as selectively stopping the division of cancer cells and causing their death. An assembly of modified oligopeptides based on a quasi-life, dynamic, self-organizing system that is effective in the treatment of oncological illnesses at all stages of the development of the cancer process where other drugs are ineffective.

Abstract: A diagnostic method for the prediction of the development and control of the effectiveness of the treatment of cardiovascular diseases, in which patient tissue samples are taken, microassay are prepared, specific antiviral immunoglobulins are processed, the number of cells infected by two or more viruses before the beginning of treatment are determined, and the dynamic of the change in the number of infected cells and their interrelationships are established: when the number of cells infected by cytomegalovirus and any other viruses decreases by more than 50±10% in patients without symptoms of cardiovascular pathology, a diagnostic conclusion is high danger of the development of atherosclerosis; if the number of cells infected by cytomegalovirus and any other viruses exceeds 50±10% in patients with demonstrated clinical signs of cardiovascular system pathology, a diagnostic conclusion is drawn of the danger of the development of complications such as arrhythmia, thrombolytic embolism.

Abstract: Industrial Application: This invention may be used in human and veterinary medicine for the design (creation and synthesis) of therapeutic and preventive drugs that are effective for the treatment of oncological and viral human and animal illnesses and for the design of new medicines. Summary of the Invention: A new method of design and synthesis of therapeutic and preventive drugs in which a biopolymer target (protein, DNA, RNA, or a mixture of these) is used, and in the capacity of a ligand, the same biopolymer target is used, which is cut into oligomer fragments (nucleases, synthetic nucleases, and proteases); the fragments are modified through changing their charges to the opposite charge (acylation of anhydrides of dicarbonate acids or alkylation with halogen-carbonic acids). Also in the capacity of a ligand, the same biopolymer target is used, which is modified by partially changing the molecules' charges to the opposite with the creation of supramolecular biopolymer assemblies.

Abstract: A method of quick laboratory diagnosis of diseases, based on the discovery of specific protein targets characteristic to the disease in the reaction of their specific interaction with other protein reagents, distinct in that specific protein targets for the given disease are hydrolyzed with proteolytic enzymes and then the chemical structure of the oligopeptide formula created is modified in such a way that its charge is changed to the opposite. This method of quick laboratory diagnosis of illnesses based on the discovery of specific proteins, and the equipment for its implementation, may be applied for the discovery of viral and microbial antigens in various human biological fluids. The method may also be used for the detection of new and little-studied infectious diseases in connection with the ease of diagnostic preparation.