Abstract: In a first aspect, the present invention relates to new recombinant artificial polypeptides allowing cytoplasmic signaling in cells containing the same. In particular, the present invention relates to a system for transmitting signals containing a recombinant polypeptide containing a domain with a first binding partner selected from an artificial ligand and a receptor binding an artificial ligand, a transmembrane domain and a cytoplasmic signaling domain whereby the domain with the binding partner and the cytoplasmic signaling domain are a combination of domains not naturally occurring in an organism and the second binding partner for specific forming of the binding pair. In a further aspect, a nucleic acid molecule comprising a nucleic acid sequence encoding the polypeptide according to the present invention as well as a vector, cell, cell line or host cell containing said vector are provided.