Patents by Inventor Arturas Petronis

Arturas Petronis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20140038840
    Abstract: The present invention provides a method of identifying one or more epigenetic markers associated with psychosis-associated diseases such as bipolar disease or schizophrenia, the method comprising a) obtaining a first group of samples comprising genomic DNA from a plurality of bipolar or schizophrenic subjects and a second group of samples comprising genomic DNA from a plurality of control subjects; b) performing DNA methylation analysis to determine methylation differences in one or more DNA regions between the first group and second group of samples, wherein a methylation difference in a DNA region is indicative of an epigenetic marker associated with bipolar disease or schizophrenia. The invention also provides one or more epigenetic markers associated with psychosis-associated diseases such as bipolar disease or schizophrenia.
    Type: Application
    Filed: August 2, 2013
    Publication date: February 6, 2014
    Applicant: CENTRE FOR ADDICTION AND MENTAL HEALTH
    Inventors: Arturas PETRONIS, Jonathan MILL, James FLANAGAN, Sun-Chong WANG
  • Publication number: 20120220475
    Abstract: The present invention provides a method of identifying one or more epigenetic markers associated with psychosis-associated diseases such as bipolar disease or schizophrenia, the method comprising a) obtaining a first group of samples comprising genomic DNA from a plurality of bipolar or schizophrenic subjects and a second group of samples comprising genomic DNA from a plurality of control subjects; b) performing DNA methylation analysis to determine methylation differences in one or more DNA regions between the first group and second group of samples, wherein a methylation difference in a DNA region is indicative of an epigenetic marker associated with bipolar disease or schizophrenia. The invention also provides one or more epigenetic markers associated with psychosis-associated diseases such as bipolar disease or schizophrenia.
    Type: Application
    Filed: December 27, 2011
    Publication date: August 30, 2012
    Applicant: CENTRE FOR ADDICTION AND MENTAL HEALTH
    Inventors: Arturas PETRONIS, Jonathan MILL, James FLANAGAN, Sun-Chong WANG
  • Publication number: 20120208711
    Abstract: The invention can be summarized as follows. There is provided a method for analyzing DNA methylation profiles of cell-free DNA in body fluids by enriching a methylated or unmethylated fraction of DNA from cell-free DNA and subjecting the enriched DNA to microarray based methylome profiling and bioinformatics data analysis.
    Type: Application
    Filed: October 1, 2010
    Publication date: August 16, 2012
    Applicant: CENTRE FOR ADDICTION AND MENTAL HEALTH
    Inventors: Rene Cortese, Arturas Petronis
  • Patent number: 8043808
    Abstract: The invention can be summarized as follows. There is provided a method for amplifying hypomethylated genomic nucleotide sequences and/or hypermethylated genomic nucleotide sequences and comparing the methylation state between different samples, for example control and test samples. Also disclosed is a microarray based method for analyzing hypo and/or hypermethylated genomic nucleotide sequence. Further, kits comprising reagents for practicing the method are provided.
    Type: Grant
    Filed: February 18, 2005
    Date of Patent: October 25, 2011
    Assignee: Centre for Addiction and Mental Health
    Inventors: Arturas Petronis, Axel Schumacher
  • Publication number: 20100234242
    Abstract: The present invention provides a method of identifying one or more epigenetic markers associated with psychosis-associated diseases such as bipolar disease or schizophrenia, the method comprising a) obtaining a first group of samples comprising genomic DNA from a plurality of bipolar or schizophrenic subjects and a second group of samples comprising genomic DNA from a plurality of control subjects; b) performing DNA methylation analysis to determine methylation differences in one or more DNA regions between the first group and second group of samples, wherein a methylation difference in a DNA region is indicative of an epigenetic marker associated with bipolar disease or schizophrenia. The invention also provides one or more epigenetic markers associated with psychosis-associated diseases such as bipolar disease or schizophrenia.
    Type: Application
    Filed: January 23, 2008
    Publication date: September 16, 2010
    Inventors: Arturas Petronis, Jonathan Mill, James Flanagan, Sun-Chong Wang
  • Publication number: 20080064030
    Abstract: The invention can be summarized as follows. There is provided a method for amplifying hypomethylated genomic nucleotide sequences and/or hypermethylated genomic nucleotide sequences and comparing the methylation state between different samples, for example control and test samples. Also disclosed is a microarray based method for analysing hypo and/or hypermethylated genomic nucleotide sequence. Further, kits comprising reagents for practising the method are provided.
    Type: Application
    Filed: February 18, 2005
    Publication date: March 13, 2008
    Inventors: Arturas Petronis, Axel Schumacher
  • Publication number: 20060172294
    Abstract: The present invention provides a method of detecting an epigenetic abnormality associated with a disease. The method comprises identifying, within a eukaryotic genome, a locus having a hypomethylated sequence specific for the disease and an endogenous multi-copy DNA element. The method can also comprise separate steps of identifying a disease-specific hypomethylated sequence and identifying an endogenous multi-copy DNA element, where the steps may be performed in any order, so long as a locus is identified that has both a disease-specific hypomethylated sequence and an endogenous multi-copy DNA element. The disease-specific hypomethylated sequences detected in accordance with the present invention indicate putative regions of epigenetic dys-regulation and indicate aberrantly regulated nucleic acid sequences that may cause or predispose a patient to disease, such as, but not limited to, Huntingdon s disease, cancers, diabetes, schizophrenia, or bipolar disorder.
    Type: Application
    Filed: June 6, 2003
    Publication date: August 3, 2006
    Inventor: Arturas Petronis