Patents by Inventor Arturo Della Torre

Arturo Della Torre has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted kynurenines and process for their preparation
    Patent number: 5786508
    Abstract: The present invention relates to the use in the treatment of cognitive disorders associated with the aging processes of the brain and perinatal brain disorders of compounds which act as inhibitors of the enzyme kynurenine aminotransferase (KAT).The present invention also provides, as novel compounds, a selected class of KAT inhibitors which are the compounds of formula (IA) ##STR1## wherein R is halogen, C.sub.1 -C.sub.6 alkyl, C.sub.5 -C.sub.7 cycloalkyl, phenyl-C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.6 alkoxy, C.sub.6 -C.sub.10 aryloxy, phenyl-C.sub.1 -C.sub.4 alkoxy or trifluoromethyl, andR.sub.1 is hydroxy, C.sub.1 -C.sub.6 alkoxy, amino, mono-C.sub.1 -C.sub.6 alkylamino, di-C.sub.1 -C.sub.6 alkylamino, hydroxylamino, C.sub.1 -C.sub.4 alkoxyamino or benzyloxyamino,with the provisos that:(i) when R.sub.1 is hydroxy and, at the same time, R is halogen, then this halogen is not fluorine; and(ii) when R.sub.1 is hydroxy and, at the same time, R is C.sub.1 -C.sub.6 alkyl, then this C.sub.1 -C.sub.
    Type: Grant
    Filed: April 6, 1995
    Date of Patent: July 28, 1998
    Assignees: Pharmacia & Upjohn S.p.A., University of Maryland at Baltimore
    Inventors: Robert Schwarcz, Mario Varasi, Arturo Della Torre, Carmela Speciale, Alberto Bianchetti
  • Substituted kynurenines and process for their preparation
    Patent number: 5708030
    Abstract: The present invention relates to the use in the treatment of cognitive disorders associated with the aging processes of the brain and perinatal brain disorders of compounds which act as inhibitors of the enzyme kynurenine aminotransferase (KAT).
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: January 13, 1998
    Assignees: University of Maryland, Pharmacia & Upjohn S.p.A.
    Inventors: Robert Schwarcz, Mario Varasi, Arturo Della Torre, Carmela Speciale, Alberto Bianchetti
  • Substituted kynurenines and process for their preparation
    Patent number: 5519055
    Abstract: The present invention relates to the use in the treatment of cognitive disorders associated with the aging processes of the brain and perinatal brain disorders of compounds which act as inhibitors of the enzyme kynurenine aminotransferase (KAT).The present invention also provides, as novel compounds, a selected class of KAT inhibitors which are the compounds of formula (IA) ##STR1## wherein R is halogen, C.sub.1 -C.sub.6 alkyl, C.sub.5 -C.sub.7 cycloalkyl, phenyl-C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.6 alkoxy, C.sub.6 -C.sub.10 aryloxy, phenyl-C.sub.1 -C.sub.4 alkoxy or trifluoromethyl, andR.sub.1 is hydroxy, C.sub.1 -C.sub.6 alkoxy, amino, mono-C.sub.1 -C.sub.6 alkylamino, di-C.sub.1 -C.sub.6 alkylamino, hydroxylamino, C.sub.1 -C.sub.4 alkoxyamino or benzyloxyamino; with the provisos that(i) when R.sub.1 is hydroxy and, at the same time, R is halogen, then this halogen is not fluorine; and(ii) when R.sub.1 is hydroxy and, at the same time, R is C.sub.1 -C.sub.6 alkyl, then this C.sub.1 -C.sub.
    Type: Grant
    Filed: August 6, 1993
    Date of Patent: May 21, 1996
    Assignees: University of Maryland at Baltimore, Pharmacia, S.p.A.
    Inventors: Robert Schwarcz, Mario Varasi, Arturo Della Torre, Carmela Speciale, Alberto Bianchetti
  • Substituted morpholine derivatives and pharmaceutical compositions
    Patent number: 4271160
    Abstract: Substituted morpholine derivatives, such as, for instance the compound 2-[.alpha.-(3,4-methylendioxy-phenoxy)-benzyl]-morpholine are disclosed.The claimed compounds are active on the central nervous system, and may be used as antidepressant agents.
    Type: Grant
    Filed: June 20, 1980
    Date of Patent: June 2, 1981
    Assignee: Farmitalia Carlo Erba S.p.A.
    Inventors: Piero Melloni, Arturo Della Torre, Giovanni C. Carniel, Alessandro Rossi
  • N-tricyclic derivatives of azetidine and process for their preparation
    Patent number: 4123527
    Abstract: Novel N-tricyclic derivatives of azetidine are disclosed of the general formula ##STR1## where A is a C.sub.1 -C.sub.3 alkylene group, a C.sub.2 -C.sub.3 alkenylene group or a cyclopropylene group, the remaining substituents being defined in the specification. Such compounds are useful for their anti-depressant, anti-convulsant and anxiolytic activities. The compound 1-[5-(10, 11-dihydro-5H-dibenzo [a,d]cyclopheptenyl)]-3-methyl-amino-azetidine is illustrative.
    Type: Grant
    Filed: January 9, 1976
    Date of Patent: October 31, 1978
    Assignee: Carlo Erba, S.p.A.
    Inventors: Piero Melloni, Arturo Della Torre, Francesco Lauria, Norina Passerini, Alessandro Rossi, Raffaele Tommasini
  • N-tricyclic derivatives of azetidine and pharmaceutical compositions and methods containing them
    Patent number: 4078072
    Abstract: Novel N-tricyclic derivatives of azetidine are disclosed of the general formula: ##STR1## WHERE A is a --CH.sub.2 --S-- or --S--CH.sub.2 -- group, the remaining substituents being defined in the specification. Illustrative is the compound 1-[11-(6,11-dihydro-dibenzo [b,e] thiopinyl)]-3-methylamino-azetidine. The compounds are useful for their anti-depressant, anti-convulsant and anxiolytic activities.
    Type: Grant
    Filed: November 2, 1976
    Date of Patent: March 7, 1978
    Assignee: Carlo Erba S.p.A.
    Inventors: Piero Melloni, Arturo Della Torre, Francesco Lauria, Norina Passerini, Alessandro Rossi, Raffaele Tommasini
  • N-tricyclic derivatives of azetidine
    Patent number: 4078073
    Abstract: Novel N-tricyclic derivatives of azetidine of the formula: ##STR1## wherein A is a --CH.sub.2 --O-- or an --O--CH.sub.2 group, and the remaining substituents being defined in the specification are disclosed. An illustrative compound is 1-[11-(6,11-dihydro-dibenzo [b,e] oxepinyl)]-3-methylamino-azetidine. The compounds are useful for their anti-depressant, anti-convulsant and anxiolytic activities.
    Type: Grant
    Filed: November 2, 1976
    Date of Patent: March 7, 1978
    Assignee: Carlo Erba S.p.A.
    Inventors: Piero Melloni, Arturo Della Torre, Francesco Lauria, Norina Passerini, Alessandro Rossi, Raffaele Tommasini