Patents by Inventor Arturo Donetti
Arturo Donetti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 5552408Abstract: A method for treating a human host suffering from psychosis, which method comprises administering to such host a therapeutically effective amount of a compound of the formula I ##STR1## wherein the radicals are defined in claim 1.Type: GrantFiled: May 1, 1994Date of Patent: September 3, 1996Assignee: Boehringer Ingelheim Italia S.p.A.Inventors: Marco Turconi, Arturo Donetti, Ernesto Montagna, Massimo Nicola, Annamaria Uberti, Rosamaria Micheletti, Antonio Giachetti
-
Patent number: 5358954Abstract: Pharmacologically active benzimidazoline-2-oxo-1-carboxylic acid compounds which are useful for treating a human host suffering from anxiety.Type: GrantFiled: March 16, 1993Date of Patent: October 25, 1994Assignee: Boehringer Ingelheim ItaliaInventors: Marco Turconi, Arturo Donetti, Ernesto Montagna, Massimo Nicola, Annamaria Uberti, Rosamaria Micheletti, Antonio Giachetti
-
Patent number: 5252570Abstract: New pharmacologically active amidino and guanidino derivatives which are 5-HT.sub.3 receptor antagonists useful as antiemetic, gastric prokinetic and antimigrainic agents of the following general formula (I) ##STR1## wherein the substituents are defined hereinbelow in the specification, which compounds are 5-HT.sub.3 receptor antagonists useful as antiemetic gastric prokinetic and antimigraine agents, inter alia.Type: GrantFiled: May 30, 1991Date of Patent: October 12, 1993Assignee: B.I. ItaliaInventors: Arturo Donetti, Marco Turconi, Massimo Nicola, Rosamaria Micheletti
-
Patent number: 5223511Abstract: New pharmacologically active benzimidazoline-2-oxo-1-carboxylic acid derivatives which are 5-HT receptor antagonists useful as antiemetic agents and as gastric prokinetic agents of the following formula: ##STR1##wherein R is hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl or C.sub.2-6 alkynyl; R.sub.1 is hydrogen; R.sub.2 is hydrogen, halogen or C.sub.1-6 alkoxy; Y is oxygen or N--R.sub.3 in which R.sub.3 is hydrogen; A is a group selected from: ##STR2##wherein p is 1; r is 0, 2 or 3: R.sub.4 is hydrogen; R.sub.5 is hydrogen, C.sub.1-6 alkyl, or R.sub.5 is a group of the formula --CR.sub.6 =N--R.sub.7 wherein R.sub.6 is hydrogen, C.sub.1-4 alkyl or amino and R.sub.7 is hydrogen or C.sub.1-6 alkyl; or a pharmaceutically acceptable acid addition salt thereof.The processes for the preparation of the compounds of formula (I) as well as pharmaceutical compositions contained in them are also described.Type: GrantFiled: March 4, 1992Date of Patent: June 29, 1993Assignee: Boehringer Ingelheim Italia S.p.A.Inventors: Marco Turconi, Arturo Donetti, Ernesto Montagna, Massimo Nicola, Annamaria Uberti, Rosamaria Micheletti, Antonio Giachetti
-
Patent number: 5164386Abstract: Pharmacologically active R(-) 3-quinuclidinol derivatives are described which are muscarinic receptor blocking agents useful for the treatment of gastrointestinal and respiratory tract disorders of the following formula (I) ##STR1## wherein R represents a linear or branched lower alkyl group, a cycloalkyl-C.sub.1-2 alkyl or an aralkyl group, or it is absent;X represents the anion of an organic or inorganic acid, or it is absent, when R is absent;R.sub.1 represents H, a linear or branched lower alkyl group or an acyl group of the type R.sub.2 --CO, in which R.sub.Type: GrantFiled: June 20, 1990Date of Patent: November 17, 1992Assignee: Istituto de Angeli S.p.A.Inventors: Enzo Cereda, Giuseppe Bietti, Giovanni B. Schiavi, Arturo Donetti, Antonio Schiavone, Henri N. Doods
-
Patent number: 5106851Abstract: Compounds of the formula (I) ##STR1## wherein R represents H or C.sub.1-6 alkyl;R.sub.1 and R.sub.2 represent H, halogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.1-6 alkythio, C.sub.1-6 alkoxycarbonyl, carboxyl, hydroxy, nitro, cyano, optionally C.sub.1-4 alkyl mono- or disubstituted carbamoyl, optionally C.sub.1-4 alkyl mono- or disubstituted amino, C.sub.1-6 acylamino, C.sub.1-4 alkoxy carbonylamino, C.sub.1-6 alkylsulphynyl, C.sub.1-6 alkylsulphonyl or C.sub.1-6 acyl;R.sub.3 represents H, C.sub.1-6 alkyl, aryl or aralkyl, or it may be absent;A represents CO or C.dbd.S;E represents nitrogen;D represents CO or CR.sub.4 R.sub.5 when the E--D bond is single, or D is C--R when the D--E bond is double, in which R.sub.4 represents H, C.sub.1-6 alkyl, aryl, aralkyl, hydroxy or C.sub.1-4 alkoxy and R.sub.5 represents H;X represents oxygen or N--R, or it is absent;Y represents a basic group selected from: ##STR2## in which n is 2 or 3; p is 0 or 1 at the same time or not; q is 0,2 or 3; R.sub.6 and R.sub.Type: GrantFiled: February 2, 1990Date of Patent: April 21, 1992Assignee: Istituto de Angeli S.p.A.Inventors: Marco Turconi, Rosamarie Micheletti, Giovanni B. Schiavi, Arturo Donetti, Angelo Sagrada, Henri N. Doods
-
Patent number: 5047410Abstract: New pharmacologically active amidino and guanidino derivatives which are 5-HT.sub.3 receptor antagonists useful as antiemetic, gastric prokinetic and antimigrainic agents of the following general formula (I) ##STR1## , wherein the substituents are defined hereinbelow, which compounds are 5-HT.sub.3 receptor antagonists useful as antiemetic gastric prokinetic and antimigraine agents, inter alia.Type: GrantFiled: July 12, 1989Date of Patent: September 10, 1991Assignee: Istituto de Angeli S.p.A.Inventors: Arturo Donetti, Marco Turconi, Massimo Nicola, Rosamaria Micheletti
-
Patent number: 4973592Abstract: New pharmacologically active heterocyclic derivatives as muscarinic receptor blocking agents, useful for the treatment of gastrointestinal disorders, of the following formula ##STR1## wherein the substituents are defined hereinbelow.Type: GrantFiled: September 13, 1988Date of Patent: November 27, 1990Assignee: Istituto de AngeliInventors: Massimo Nicola, Arturo Donetti, Enzo Cereda, Marco Turconi, Giovanni B. Schiavi, Rosamaria Micheletti
-
Patent number: 4699915Abstract: Compounds of the formula ##STR1## wherein R is hydrogen or methyl;R.sub.1 is straight or branched alkyl of 1 to 6 carbon atoms, hydroxy(alkyl of 1 to 6 carbon atoms), mono- or di-(alkoxy of 1 to 6 carbon atoms)(alkyl of 1 to 6 carbon atoms), (alkyl of 1 to 6 cabon atoms)thio(alkyl of 1 to 6 carbon atoms), cyano(alkyl of 1 to 6 carbon atoms), alkenyl, alkynyl, or cycloalkyl;R.sub.2 is hydrogen, alkyl of 1 to 3 carbon atoms, alkoxy of 1 to 3 carbon atoms or halogen; andX is pyrazol-3-yl, 1,2,4-triazol-3-yl, pyridin-2-yl, pyridin-3-yl, thiazol-4-yl, 2-methyl-thiazol-4-yl or 2-methylamino-thiazol-4-yl;tautomers thereof, and non-toxic, pharmacologiically acceptable acid addition salts thereof. The compounds as well as their salts are useful as antiulcerogenics and gastric acid secretion inhibitors.Type: GrantFiled: July 2, 1985Date of Patent: October 13, 1987Assignee: Istituto de Angeli S.p.A.Inventors: Enzo Cereda, Giuseppe Bietti, Arturo Donetti, Piero del Soldato, Antonio Giachetti, Ferdinando Pagani
-
Patent number: 4666932Abstract: Compounds of the formula ##STR1## wherein R is hydrogen or methyl;R.sub.1 is straight or branched alkyl of 1 to 6 carbon atoms, dimethyldioxolylmethyl, hydroxymethyldioxolylmethyl, hydroxy(alkyl of 1 to 6 carbon atoms), mono- or di-(alkoxy of 1 to 6 carbon atoms)(alkyl of 1 to 6 carbon atoms), (alkyl of 1 to 6 carbon atoms)thio- (alkyl of 1 to 6 carbon atoms), (alkoxy of 1 to 6 carbon atoms)(alkyl of 1 to 6 carbon atoms)thio-(alkyl of 1 to 6 carbon atoms), cyano(alkyl of 1 to 6 carbon atoms), di-lower alkyl-amino(alkyl of 1 to 6 carbon atoms), alkenyl, alkynyl, or cycloalkyl;R.sub.2 and R.sub.3 are each independently hydrogen, alkyl of 1 to 3 carbon atoms, alkoxy of 1 to 3 carbon atoms or halogen; andZ is imidazol-2-yl or imidazol-4-yl;provided however that, when R.sub.1 is straight or branched alkyl, alkenyl, alkynyl, cycloalkyl or cyano and R, R.sub.2 and R.sub.3 are hydrogen, Z is other than imidazol-4-yl; tautomers thereof and non-toxic, pharmacologically acceptable acid addition salts thereof.Type: GrantFiled: July 2, 1985Date of Patent: May 19, 1987Assignee: Istituto de Angeli S.p.A.Inventors: Enzo Cereda, Giuseppe Bietti, Arturo Donetti, Piero del Soldato, Antonio Giachetti, Ferdinando Pagani
-
Patent number: 4649150Abstract: Compounds of the formula ##STR1## wherein R represents substituents of various types;R.sub.1 and R.sub.2 are each independently hydrogen or lower alkyl;R.sub.3 represents substituents of various types; andR.sub.4 is hydrogen, alkyl of 1 to 3 carbon atoms, alkoxy of 1 to 3 carbon atoms, halogen, cyano or carbamoyl;tautomers thereof; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as antiulcerogenics.Type: GrantFiled: May 16, 1984Date of Patent: March 10, 1987Assignee: Istituto de Angeli, S.p.A.Inventors: Giuseppe Bietti, Enzo Cereda, Arturo Donetti, Antonio Giachetti, Ferdinando Pagani
-
Patent number: 4645841Abstract: Compounds of the tautomeric formula ##STR1## wherein R, R.sub.1 and R.sub.2, which may be identical to or different from each other, are each hydrogen or alkyl of 1 to 4 carbon atoms;R.sub.3 is straight or branched alkyl, optionally interrupted by heteroatoms such as oxygen, sulfur or nitrogen; straight or branched alkenyl; alkynyl; cyano; cycloalkyl or cycloaliphatic alkyl; a bicyclic group; aryl; or a heterocyclic group; orR.sub.2 and R.sub.3, together with each other and the nitrogen atoms to which they are attached, form a heterocyclic group;R.sub.4 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms or alkoxy of 1 to 4 carbon atoms; andHet is a substituted or unsubstituted heterocycle containing two or three heteroatoms; tautomers thereof, and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as anti-ulcerogenics.Type: GrantFiled: June 24, 1985Date of Patent: February 24, 1987Assignee: Istituto de Angeli, S.p.A.Inventors: Giuseppe Bietti, Enzo Cereda, Arturo Donetti, Piero Del Soldato, Antonio Giachetti, Rosamaria Micheletti
-
Patent number: 4643993Abstract: Compounds of the formula ##STR1## wherein Het is a heterocycle containing 2 to 3 nitrogen atoms;R is hydrogen, lower alkyl, alkoxy of 1 to 3 carbon atoms or halogen;Y is --SO.sub.3 H or ##STR2## R" is alkyl of 1 to 3 carbon atoms; and R' is straight or branched alkyl which may contain a heteroatom such as sulfur, oxygen or nitrogen; straight or branched alkenyl; cycloalkyl; alkyl-cycloalkyl; aryl; or aralkyl optionally substituted by lower alkyl, alkoxy of 1 to 3 carbon atoms or halogen; tautomers thereof, and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as anti-ulcerogenics and gastric acid secretion inhibitors.Type: GrantFiled: May 18, 1983Date of Patent: February 17, 1987Assignee: Istituto de Angeli S.p.A.Inventors: Enzo Cereda, Arturo Donetti, Antonio Giachetti, Piero del Soldato
-
Patent number: 4548944Abstract: Compounds of the tautomeric formula ##STR1## wherein R, R.sub.1 and R.sub.2, which may be identical to or different from each other, are each hydrogen or alkyl of 1 to 4 carbon atoms;R.sub.3 is straight or branched alkyl, optionally interrupted by heteroatoms such as oxygen, sulfur or nitrogen; straight or branched alkenyl; alkynyl; cyano; cycloalkyl or cycloaliphatic alkyl; a bicyclic group; aryl; or a heterocyclic group; orR.sub.2 and R.sub.3, together with each other and the nitrogen atoms to which they are attached, form a heterocyclic group;R.sub.4 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms or alkoxy of 1 to 4 carbon atoms; andHet is a substituted or unsubstituted heterocycle containing two or three heteroatoms;tautomers thereof, and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as anti-ulcerogenics.Type: GrantFiled: February 10, 1983Date of Patent: October 22, 1985Assignee: Istituto de Angeli S.p.A.Inventors: Giuseppe Bietti, Enzo Cereda, Arturo Donetti, Piero del Soldato, Antonio Giachetti, Rosamaria Micheletti
-
Patent number: 4465841Abstract: This invention relates to imidazolylphenyl amidines, the preparation thereof, and pharmaceutical compositions containing them. More particularly, this invention relates to compounds of the general formula ##STR1## in which R, R.sub.1, and R.sub.3, which may be the same or different, each represent a hydrogen atom or a lower alkyl group, and R.sub.2 represents a linear or branched alkyl, alkenyl, or alkynyl group, a cyano group, a hydroxyl group, a substituted or unsubstituted cycloalkyl or cycloaliphatic alkyl group, a bicyclic group, an aralkyl or aryl group optionally substituted by halogen, methyl, methoxy, or methylenedioxy groups, or a substituted or unsubstituted heterocyclylalkyl or heterocyclic group which may also contain a further hetero atom, or a non-toxic, pharmacologically acceptable acid addition salt thereof. These compounds are useful in treating disorders of the gastrointestinal tract.Type: GrantFiled: September 29, 1982Date of Patent: August 14, 1984Assignee: Instituto de Angeli S.p.A.Inventors: Enzo Cereda, Arturo Donetti, Piero Del Soldato, Mario Bergamaschi
-
Patent number: 4386099Abstract: This invention relates to imidazolylphenyl amidines, the preparation thereof, and pharmaceutical compositions containing them. More particularly, this invention relates to compounds of the general formula ##STR1## in which R, R.sub.1, R.sub.3, which may be the same or different, each represent a hydrogen atom or a lower alkyl group, and R.sub.2 represents a linear or branched alkyl, alkenyl, or alkynyl group, a cyano group, a hydroxyl group, a substituted or unsubstituted cycloalkyl or cycloaliphatic alkyl group, a bicyclic group, an aralkyl or aryl group optionally substituted by halogen, methyl, methoxy, or methylenedioxy groups, or a substituted or unsubstituted heterocyclylalkyl or heterocyclic group which may also contain a further hetero atom, or a non-toxic, pharmacologically acceptable acid addition salt thereof. These compounds are useful in treating disorders of the gastrointestinal tract.Type: GrantFiled: November 19, 1981Date of Patent: May 31, 1983Assignee: Istituto de Angeli S.p.A.Inventors: Enzo Cereda, Arturo Donetti, Piero del Soldato, Mario Bergamaschi
-
Patent number: 4259253Abstract: A novel process for the preparation of pure trans, trans-farnesylacetic acid of the formula ##STR1## by recrystallization of a mixture of alkali metal salts of trans, trans- and cis, trans-farnesylacetic acid from an organic solvent, and conversion of the isolated alkali metal trans, trans-farnesylacetate into the free acid.Type: GrantFiled: January 28, 1980Date of Patent: March 31, 1981Assignee: Istituto de Angeli S.p.A.Inventors: Arturo Donetti, Enzo Cereda, Elio Bellora
-
Patent number: 3952108Abstract: The specification describes quaternary bromides of scopolamine in which the substituent on the nitrogen atom has the formula --(CH.sub.2).sub.n -R in which R represents a cycloalkyl group containing up to six carbon atoms, an alkyl-substituted cycloalkyl group containing up to six carbon atoms or an epoxyethyl group and n is 1 or 2. Such compounds have valuable spasmolytic and anti-ulcer properties and pharmaceutical preparations containing them are also described.Type: GrantFiled: July 22, 1974Date of Patent: April 20, 1976Assignee: Istituto de Angeli S.p.A.Inventors: Silvano Casadio, Arturo Donetti