Abstract: A system for analysing a brain image compares the image with a brain atlas, labels the image accordingly, and annotating the regions of interest and/or other structures. This atlas-enhanced data is written to a file (or more than one file) in the Dicom format or any web-enabled format such as SGML or XML format. The image used may be produced by any medical imaging modality. A fast algorithm is proposed for a landmark-based piecewise linear mapping of one volumetric image into another volumetric image. Furthermore, a new set of brain landmarks are proposed, and algorithms for the automatic identification of these landmarks are formulated for three orientations, axial, coronal, and sagittal.