Abstract: Methods, devices, and systems for detecting return-oriented programming (ROP) exploits are disclosed. A system includes a processor, a main memory, and a cache memory. A cache monitor develops an instruction loading profile by monitoring accesses to cached instructions found in the cache memory and misses to instructions not currently in the cache memory. A remedial action unit terminates execution of one or more of the valid code sequences if the instruction loading profile is indicative of execution of an ROP exploit involving one or more valid code sequences. The instruction loading profile may be a hit/miss ratio derived from monitoring cache hits relative to cache misses. The ROP exploits may include code snippets that each include an executable instruction and a return instruction from valid code sequences.