Patents by Inventor Arun K Roy

Arun K Roy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Estrogen receptor site-specific ribozymes and uses thereof for estrogen dependent tumors
    Patent number: 7179593
    Abstract: Highly specific hammerhead ribozymes are provided that human target estrogen receptor mRNA. These ribozymes, designated RZ1 through RZ7 provide predictable mRNA cleavage products. Methods for inhibiting estrogen-dependent tumor growth, such as that characteristic of breast cancer, are also provided employing these ribozymes. One or both of the ribozymes may be used together or separately with equal efficiency. The ribozymes possess a sequence region with a catalytic core that provides the attributed catalytic activity to these ribozymes.
    Type: Grant
    Filed: June 2, 2000
    Date of Patent: February 20, 2007
    Assignee: Board of Regents, The University of Texas System
    Inventors: Arun K. Roy, Yan Lavrovsky, Rakesh K. Tyagi, Chung S. Song, Bandana Chatterjee, Shuo Chen
  • Ribozyme mediated inactivation of the androgen receptor
    Patent number: 7067256
    Abstract: The present invention provides synthetic ribozyme oligonucleotides alone and within constructs. The ribozyme gene provides methods for the treatment of prostate hyperplasia and other androgen dependent pathologies. Improved therapies for such diseases are provided without significant hormonal imbalance and without surgical intervention. Also provided are techniques for selecting and synthesizing effective and specifically targeted molecular tools for use in inhibiting androgen receptor gene expression.
    Type: Grant
    Filed: September 17, 2002
    Date of Patent: June 27, 2006
    Assignee: Board of Regents, The University of Texas System
    Inventors: Arun K Roy, Shuo Chen
  • Ribozyme mediated inactivation of the androgen receptor
    Publication number: 20030077639
    Abstract: The present invention provides synthetic ribozyme oligonucleotides alone and within constructs. The ribozyme gene provides methods for the treatment of prostate hyperplasia and other androgen dependent pathologies. Improved therapies for such diseases are provided without significant hormonal imbalance and without surgical intervention. Also provided are techniques for selecting and synthesizing effective and specifically targeted molecular tools for use in inhibiting androgen receptor gene expression.
    Type: Application
    Filed: September 17, 2002
    Publication date: April 24, 2003
    Applicant: Board of Regents, The University of Texas System
    Inventors: Arun K. Roy, Shuo Chen
  • Ribozyme mediated inactivation of the androgen receptor
    Patent number: 6489163
    Abstract: The present invention provides synthetic ribozyme oligonucleotides alone and within constructs. The ribozyme gene provides methods for the treatment of prostate hyperplasia and other androgen dependent pathologies. Improved therapies for such diseases are provided without significant hormonal imbalance and without surgical intervention. Also provided are techniques for selecting and synthesizing effective and specifically targeted molecular tools for use in inhibiting androgen receptor gene expression.
    Type: Grant
    Filed: May 8, 1997
    Date of Patent: December 3, 2002
    Assignee: Board of Regents, The University of Texas System
    Inventors: Arun K Roy, Shuo Chen
  • Methods and compositions relating to the androgen receptor gene and uses thereof
    Patent number: 5556956
    Abstract: Disclosed are methods and compositions, including antisense and antigene constructs and pharmaceutical formulations thereof, for use in regulating androgen receptor gene expression. The promoter activity of the androgen receptor gene is herein shown to include a critical upstream acting domain with a unique sequence, the unique nucleic acid sequence corresponding to positions 1697 and 2084, particularly between positions 1697 and 1717, as defined in SEQ ID NO:1. The AR gene promoter sequence, herein characterized as having a a particular nucleotide sequence defined between nucleotides 1697 and 2084 of SEQ ID NO:1, is characterized as important in the regulation of androgen receptor gene expression.
    Type: Grant
    Filed: November 4, 1993
    Date of Patent: September 17, 1996
    Assignee: Board of Regents, The University of Texas System
    Inventors: Arun K. Roy, Bandana Chatterjee