Patents by Inventor Arun K. Sarkar
Arun K. Sarkar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11878026Abstract: Compounds, compositions, and methods for treatment and/or prevention of at least one disease, disorder, and/or condition by inhibiting binding of an E-selectin to an E-selectin ligand are disclosed. For example, E-selectin antagonists are described and pharmaceutical compositions comprising at least one of the same.Type: GrantFiled: November 9, 2021Date of Patent: January 23, 2024Assignee: GLYCOMIMETICS, INC.Inventors: John L. Magnani, John M. Peterson, Arun K. Sarkar, Yusuf U. Vohra, Myung-Gi Baek
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Patent number: 11873317Abstract: Compounds, compositions, and methods for treatment and/or prevention of at least one disease, disorder, and/or condition by inhibiting binding of galectin-3 to ligands are disclosed. For example, inhibitors of galectin-3 are described and pharmaceutical compositions comprising at least one such agent is described.Type: GrantFiled: December 26, 2019Date of Patent: January 16, 2024Assignee: GLYCOMIMETICS, INC.Inventors: John L. Magnani, John M. Peterson, Arun K. Sarkar, Yusufbhai U. Vohra, Indranath Ghosh, Jason Nogueira
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Patent number: 11845771Abstract: Compounds, compositions, and methods for treatment and/or prevention of at least one disease, disorder, and/or condition by inhibiting binding of an E-selectin, galectin-3, or E-selectin and galectin-3 to ligands are disclosed. For example, heterobifunctional inhibitors of E-selectin and galectin-3 are described and pharmaceutical compositions comprising at least one such agent is described.Type: GrantFiled: December 26, 2019Date of Patent: December 19, 2023Assignee: GLYCOMIMETICS, INC.Inventors: John L. Magnani, John M. Peterson, Arun K. Sarkar, Yusufbhai U. Vohra, Indranath Ghosh, Jason Nogueira
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Publication number: 20230097694Abstract: Methods and compositions using E-selectin antagonists are provided for the treatment and prevention of diseases and disorders treatable by inhibiting binding of E-selectin to an E-selectin ligand. Described herein are E-selectin antagonists including, for example, glycomimetic compounds, antibodies, aptamers and peptides that are useful in methods for treatment of cancers, and treatment and prevention of metastasis, inhibiting infiltration of the cancer cells into bone marrow, reducing or inhibiting adhesion of the cancer cells to endothelial cells including cells in bone marrow, and inhibiting thrombus formation.Type: ApplicationFiled: April 20, 2022Publication date: March 30, 2023Applicant: GLYCOMIMETICS, INC.Inventors: John L. MAGNANI, Arun K. SARKAR, Myung-Gi BAEK, Frank E. ANDERSON, III, Yanhong LI
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Publication number: 20230091472Abstract: Compounds, compositions, and methods for treatment and/or prevention of at least one disease, disorder, and/or condition by inhibiting binding of galectin-3 to ligands are disclosed. For example, inhibitors of galectin-3 are described and pharmaceutical compositions comprising at least one such agent are described.Type: ApplicationFiled: December 23, 2020Publication date: March 23, 2023Applicant: GLYCOMIMETICS, INC.Inventors: John L. MAGNANI, John M. PETERSON, Yusuf U. VOHRA, lndranath GHOSH, Jason NOGUEIRA, Arun K. SARKAR, Debatosh MAJUMDAR
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Publication number: 20230079833Abstract: Compounds, compositions, and methods for treating and/or preventing at least one disease, disorder, and/or condition N associated with E-selectin, galectin-3, and/or CXCR4 chemokine receptor activity are disclosed herein. For example, multimeric glycomimetic inhibitors of E-selectins, galectin-3, and/or CXCR4 chemokine receptors and their use for treating and/or preventing inflammatory diseases, fibrosis, and cancers are disclosed. Formula (I).Type: ApplicationFiled: April 21, 2020Publication date: March 16, 2023Applicant: GLYCOMIMETICS, INC.Inventors: John L. MAGNANI, John M. PETERSON, Arun K. SARKAR, Yusufbhai U. VOHRA, Myung-Gi BAEK, Hong-Woon YANG
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Patent number: 11548908Abstract: Compounds, compositions, and methods for treatment and/or prevention of at least one disease, disorder, and/or condition by inhibiting binding of an E-selectin, galectin-3, or E-selectin and galectin-3 to ligands a disclosed. For example, heterobifunctional inhibitors of E-selectin and galectin-3 are described and pharmaceutical compositions comprising at least one such agent is described.Type: GrantFiled: December 28, 2018Date of Patent: January 10, 2023Assignee: GlycoMimetics, Inc.Inventors: John L. Magnani, John M. Peterson, Arun K. Sarkar, Yusufbhai U. Vohra, Hong-Woon Yang
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Publication number: 20220289784Abstract: A process is provided for the synthesis of an intermediate of Formula 15 which is useful in the synthesis of E-selectin inhibitors. Also provided are useful intermediates obtained from the process.Type: ApplicationFiled: August 18, 2020Publication date: September 15, 2022Applicant: GLYCOMIMETICS, INC.Inventors: Henry H. Flanner, John M. Peterson, Arun K. Sarkar, John L. Magnani, Gerd Osswald, Daniel Schwizer, Marc Lanz, Andreas Helmut Bernd Kyas
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Publication number: 20220175808Abstract: Compounds, compositions, and methods for treatment and/or prevention of at least one disease, disorder, and/or condition by inhibiting binding of an E-selectin to an E-selectin ligand are disclosed. For example, E-selectin antagonists are described and pharmaceutical compositions comprising at least one of the same.Type: ApplicationFiled: November 9, 2021Publication date: June 9, 2022Applicant: GLYCOMIMETICS, INC.Inventors: John L. MAGNANI, John M. PETERSON, Arun K. SARKAR, Yusuf U. VOHRA, Myung-Gi BAEK
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Patent number: 11332491Abstract: Methods and compositions using E-selectin antagonists are provided for the treatment and prevention of diseases and disorders treatable by inhibiting binding of E-selectin to an E-selectin ligand. Described herein are E-selectin antagonists including, for example, glycomimetic compounds, antibodies, aptamers and peptides that are useful in methods for treatment of cancers, and treatment and prevention of metastasis, inhibiting infiltration of the cancer cells into bone marrow, reducing or inhibiting adhesion of the cancer cells to endothelial cells including cells in bone marrow, and inhibiting thrombus formation.Type: GrantFiled: August 17, 2020Date of Patent: May 17, 2022Assignee: GLYCOMIMETICS, INC.Inventors: John L. Magnani, Arun K. Sarkar, Myung-Gi Baek, Frank E. Anderson, III, Yanhong Li
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Publication number: 20220089633Abstract: Compounds, compositions, and methods for treatment and/or prevention of at least one disease, disorder, and/or condition by inhibiting binding of an E-selectin, galectin-3, or E-selectin and galectin-3 to ligands are disclosed. For example, heterobifunctional inhibitors of E-selectin and galectin-3 are described and pharmaceutical compositions comprising at least one such agent is described.Type: ApplicationFiled: December 26, 2019Publication date: March 24, 2022Applicant: GLYCOMIMETICS, INC.Inventors: John L. MAGNANI, John M. PETERSON, Arun K. SARKAR, Yusufbhai U. VOHRA, Indranath GHOSH, Jason NOGUEIRA
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Publication number: 20220073555Abstract: Compounds, compositions, and methods for treatment and/or prevention of at least one disease, disorder, and/or condition by inhibiting binding of galectin-3 to ligands are disclosed. For example, inhibitors of galectin-3 are described and pharmaceutical compositions comprising at least one such agent is described.Type: ApplicationFiled: December 26, 2019Publication date: March 10, 2022Applicant: GLYCOMIMETICS, INC.Inventors: John L. MAGNANI, John M. PETERSON, Arun K. SARKAR, Yusufbhai U. VOHRA, Indranath GHOSH, Jason NOGUEIRA
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Patent number: 11197877Abstract: Compounds, compositions, and methods for treatment and/or prevention of at least one disease, disorder, and/or condition by inhibiting binding of an E-selectin to an E-selectin ligand are disclosed. For example, E-selectin antagonists are described and pharmaceutical compositions comprising at least one of the same.Type: GrantFiled: March 12, 2018Date of Patent: December 14, 2021Assignee: GLYCOMIMETICS. INC.Inventors: John L Magnani, John M Peterson, Arun K Sarkar, Yusuf U Vohra, Myung-Gi Baek
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Patent number: 11045485Abstract: Compounds, compositions, and methods for the diagnosis and/or treatment of medical conditions involving infections with and colonization by Pseudomonas bacteria including, for example, Pseudomonas aeruginosa in the lungs of patients with cystic fibrosis are described.Type: GrantFiled: January 18, 2017Date of Patent: June 29, 2021Assignee: GlycoMimetics, Inc.Inventors: John L Magnani, Arun K. Sarkar
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Publication number: 20210017215Abstract: Methods and compositions using E-selectin antagonists are provided for the treatment and prevention of diseases and disorders treatable by inhibiting binding of E-selectin to an E-selectin ligand. Described herein are E-selectin antagonists including, for example, glycomimetic compounds, antibodies, aptamers and peptides that are useful in methods for treatment of cancers, and treatment and prevention of metastasis, inhibiting infiltration of the cancer cells into bone marrow, reducing or inhibiting adhesion of the cancer cells to endothelial cells including cells in bone marrow, and inhibiting thrombus formation.Type: ApplicationFiled: August 17, 2020Publication date: January 21, 2021Applicant: GLYCOMIMETICS, INC.Inventors: John L. MAGNANI, Arun K. SARKAR, Myung-Gi BAEK, Frank E. ANDERSON, III, Yanhong LI
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Publication number: 20200399301Abstract: Compounds, compositions, and methods for treatment and/or prevention of at least one disease, disorder, and/or condition by inhibiting binding of an E-selectin, galectin-3, or E-selectin and galectin-3 to ligands a disclosed. For example, heterobifunctional inhibitors of E-selectin and galectin-3 are described and pharmaceutical compositions comprising at least one such agent is described.Type: ApplicationFiled: December 28, 2018Publication date: December 24, 2020Applicant: GLYCOMIMETICS, INC.Inventors: John L. MAGNANI, John M. PETERSON, Arun K. SARKAR, Yusufbhai U. VOHRA, Hong-Woon YANG
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Patent number: 10766916Abstract: Methods and compositions using E-selectin antagonists are provided for the treatment and prevention of diseases and disorders treatable by inhibiting binding of E-selectin to an E-selectin ligand. Described herein are E-selectin antagonists including, for example, glycomimetic compounds, antibodies, aptamers and peptides that are useful in methods for treatment of cancers, and treatment and prevention of metastasis, inhibiting infiltration of the cancer cells into bone marrow, reducing or inhibiting adhesion of the cancer cells to endothelial cells including cells in bone marrow, and inhibiting thrombus formation.Type: GrantFiled: November 20, 2019Date of Patent: September 8, 2020Assignee: GLYCOMIMETICS, INC.Inventors: John L. Magnani, Arun K. Sarkar, Myung-Gi Baek, Frank E. Anderson, III, Yanhong Li
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Publication number: 20200157134Abstract: Methods and compositions using E-selectin antagonists are provided for the treatment and prevention of diseases and disorders treatable by inhibiting binding of E-selectin to an E-selectin ligand. Described herein are E-selectin antagonists including, for example, glycomimetic compounds, antibodies, aptamers and peptides that are useful in methods for treatment of cancers, and treatment and prevention of metastasis, inhibiting infiltration of the cancer cells into bone marrow, reducing or inhibiting adhesion of the cancer cells to endothelial cells including cells in bone marrow, and inhibiting thrombus formation.Type: ApplicationFiled: November 20, 2019Publication date: May 21, 2020Applicant: GlycoMimetics, Inc.Inventors: John L. MAGNANI, Arun K. SARKAR, Myung-Gi BAEK, Frank E. ANDERSON, III, Yanhong LI
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Publication number: 20200129536Abstract: Compounds, compositions, and methods for treatment and/or prevention of at least one disease, disorder, and/or condition by inhibiting binding of an E-selectin to an E-selectin ligand are disclosed. For example, E-selectin antagonists are described and pharmaceutical compositions comprising at least one of the same.Type: ApplicationFiled: March 12, 2018Publication date: April 30, 2020Applicant: GLYCOMIMETICS, INC.Inventors: John L MAGNANI, John M PETERSON, Arun K SARKAR, Yusufbhai U VOHRA, Myung-Gi BAEK
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Patent number: 10526361Abstract: Methods and compositions using E-selectin antagonists are provided for the treatment and prevention of diseases and disorders treatable by inhibiting binding of E-selectin to an E-selectin ligand. Described herein are E-selectin antagonists including, for example, glycomimetic compounds, antibodies, aptamers and peptides that are useful in methods for treatment of cancers, and treatment and prevention of metastasis, inhibiting infiltration of the cancer cells into bone marrow, reducing or inhibiting adhesion of the cancer cells to endothelial cells including cells in bone marrow, and inhibiting thrombus formation.Type: GrantFiled: September 19, 2017Date of Patent: January 7, 2020Assignee: GlycoMimetics, Inc.Inventors: John L. Magnani, Arun K. Sarkar, Myung-Gi Baek, Frank E. Anderson, III, Yanhong Li